The analysis of clinical epidemiological characteristics of herpangina by enterovirus in Tianjin City, 2014
-
摘要: 目的 探讨天津市疱疹性咽峡炎的发生情况及其流行特征。方法 采集了134例疱疹性咽峡炎患者中的133份咽拭子标本和54份粪便标本并进行肠道病毒(enterovirus,EV)检测,同时入户对所有患者进行流行病学调查。结果 134例疱疹性咽峡炎患者EV阳性率为64.93%,其中柯萨奇病毒A10(coxsackie virus A10,CoxA10)占34.48%、柯萨奇病毒A16(coxsackie virus A16,CoxA16)占29.89%。咽拭子标本的阳性率和粪便标本的阳性率一致性较高(Kappa值=0.709,P<0.001)。临床症状中发热、咽痛、呕吐、惊厥的比例均高于同期手足口病患者(均有P<0.05)。不同月疱疹性咽峡炎的主要流行病原不同(χ2=28.652,P<0.001),且与同期手足口病流行的主要病原不同(均有P<0.05),但总体上病原种类一致。结论 作为肠道病毒传染源之一的疱疹性咽峡炎患者应与手足口病一起纳入监测管理。Abstract: Objective To study the incidence and epidemiological characteristics of herpangina in Tianjin. Methods A total of 134 herpangina cases were investigated, 133 throat swabs and 54 stool samples were tested. Results Enterovirus positive rate of 134 herpangina cases was 64.93%, of which coxsackie virus A10 accounted for 34.48%, and coxsackie virus A16 accounted for 29.89%. The pan-enterovirus positive rate of stool samples were in accordance with the rate of throat swabs (Kappa=0.709,P<0.001).The proportion of some symptoms including fever, sore throat, vomit and convulsions was higher in herpangina patients than in the hand-foot-mouth disease cases (all P<0.05). The major epidemic enterovirus of herpangina was different among different month (χ2=28.652,P<0.001). Although there were difference between herpangina and hand-foot-mouth disease in major epidemic enterovirus (all P<0.05), the types of enterovirus were consistent. Conclusions As one of enterovirus infection source, herpangina patients should be included in the monitoring and management together with hand-foot-mouth disease.
-
Key words:
- Herpangina /
- Epidemiology /
- Hand,food and mouth disease
-
贺锦华,赵小红,马利维,等. 118例疱疹性咽峡炎患儿心肌损伤临床分析 [J]. 检验医学与临床, 2012,(19):2442-2443. 王宏宇,张小爱,许红梅,等. 手足口病患者不同标本中肠道病毒检测结果比较 [J]. 中华疾病控制杂志, 2014,18(6):501-503. 冯子健,曾光,马会来,等. 传染病控制手册 [M]. 北京:中国协和医科大学出版社, 2008:139-141. Puenpa J, Chieochansin T, Linsuwanon P, et al. Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand,2012 [J]. Emerg Infect Dis, 2013,19(4):641-643. Lee CJ, Huang YC, Yang S, et al. Clinical features of coxsackievirus A4, B3 and B4 infections in children [J]. PLoS One, 2014,9(2):e87391. Oliveira DB, Campos RK, Soares MS, et al. Outbreak of herpangina in the Brazilian Amazon in 2009 caused by Enterovirus B [J]. Arch Virol, 2014,159(5):1155-1157. Mirand A, Henquell C, Archimbaud C, et al. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study [J]. Clin Microbiol Infect, 2012,18(5):E110-E118. Linsuwanon P, Puenpa J, Huang SW, et al. Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations [J]. J Biomed Sci, 2014,18(21):16. Park K, Lee B, Baek K, et al. Enteroviruses isolated herpangina and hand-foot-and-mouth disease in Korean children [J]. Virol J, 2012,17(9):205. 甘正凯,李靖欣,孟繁岳,等. 肠道病毒71型所致疾病及其流行病学特征 [J]. 中华流行病学杂志, 2015,36(1):45-48. 董玉颖,孟繁,岳储凯,等. 江苏省农村地区柯萨奇病毒A16感染所致疾病及其流行特征 [J]. 中华预防医学杂志, 2013,47(6):575-576. Miyazawa I, Azegami Y, Kasuo S, et al. Prevalence of enterovirus from patients with herpangina and hand, foot and mouth disease in Nagano Prefecture, Japan, 2007 [J]. Jpn J Infect Dis, 2008,61(3):247-248. 胡跃华,廖家强,冯国双,等. 自回归移动平均模型在全国手足口病疫情预测中的应用 [J]. 疾病监测, 2014,29(10):827-832. Lee MH, Huang LM, Wong WW, et al. Molecular diagnosis and clinical presentations of enteroviral infections in Taipei during the 2008 epidemic [J]. J Microbiol Immunol Infect, 2011,44(3):178-183.
点击查看大图
计量
- 文章访问数: 526
- HTML全文浏览量: 141
- PDF下载量: 313
- 被引次数: 0