Research on the correlation between lipid accumulation product and carotid atherosclerosis in people with high risk of cardiovascular diseases

GU Yibin; GU Shujun; ZHANG Qiuyi; CHEN Lulu

doi:10.16462/j.cnki.zhjbkz.2025.06.007

Volume 29 Issue 6

Jun. 2025

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2025 > 29(6): 669-674

GU Yibin, GU Shujun, ZHANG Qiuyi, CHEN Lulu. Research on the correlation between lipid accumulation product and carotid atherosclerosis in people with high risk of cardiovascular diseases[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 669-674. doi: 10.16462/j.cnki.zhjbkz.2025.06.007

Citation:

GU Yibin, GU Shujun, ZHANG Qiuyi, CHEN Lulu. Research on the correlation between lipid accumulation product and carotid atherosclerosis in people with high risk of cardiovascular diseases[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 669-674. doi: 10.16462/j.cnki.zhjbkz.2025.06.007

Citation:

GU Yibin, GU Shujun, ZHANG Qiuyi, CHEN Lulu. Research on the correlation between lipid accumulation product and carotid atherosclerosis in people with high risk of cardiovascular diseases[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 669-674. doi: 10.16462/j.cnki.zhjbkz.2025.06.007

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Research on the correlation between lipid accumulation product and carotid atherosclerosis in people with high risk of cardiovascular diseases

doi: 10.16462/j.cnki.zhjbkz.2025.06.007

1.
Changshu Center for Disease Control and Prevention, Changshu 215500, China
2.
Department of Non-Communicable Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China

Funds: Chinese Central Government Key Project of Public Health Program

More Information

Corresponding author: CHEN Lulu, E-mail: chenlulu136@163.com
Received Date: 2025-01-03
Rev Recd Date: 2025-02-27

Available Online: 2025-07-07

Publish Date: 2025-06-10

Abstract

Abstract

Objective To learn the correlation between the lipid accumulation product index (LAP) and the risk of carotid atherosclerosis in people with high risk of cardiovascular diseases, and provide scientific basis for intervention in people with high risk of cardiovascular diseases. Methods Based on the programme of screening and intervention subjects with high risk cardiovascular diseases in Jiangsu Province from September 2015 to June 2016, the general situation of high-risk groups of cardiovascular disease in different genders and ages was analyzed by χ² /F test through questionnaires, physical measurements, laboratory tests and carotid ultrasound examination, and the possible confounding factors were adjusted. Multivariate logistic regression model was used to explore the relationship between LAP and carotid atherosclerosis. Results Compared to male and those aged over 60 years old, females and those aged 60 years old or below had a higher LAP index, and the differences were statistically significant (all P < 0.001). Regression analysis showed that for every standard deviation increase in the lipid accumulation product, the risk of carotid artery plaque increased by 6% (OR=1.06, 95% CI: 1.01-1.12, P=0.026). Interaction analysis results showed that compared with female and non-drinking people, male and drinking people with high risk of cardiovascular diseases have a higher risk of carotid plaque (interaction tests P < 0.05, respectively). Conclusions In people with high risk of cardiovascular diseases, the LAP was positively correlated with the carotid plaque, and the positive correlation were stronger in male and alcohol drinking.
- Lipid accumulation product index,
- Carotid atherosclerosis,
- Men,
- Drinking

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References(21)

References

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