• 中国精品科技期刊
  • 《中文核心期刊要目总览》收录期刊
  • RCCSE 中国核心期刊(5/114,A+)
  • Scopus收录期刊
  • 美国《化学文摘》(CA)收录期刊
  • WHO 西太平洋地区医学索引(WPRIM)收录期刊
  • 《中国科学引文数据库(CSCD)》核心库期刊 (C)
  • 中国科技核心期刊
  • 中国科技论文统计源期刊
  • 《日本科学技术振兴机构数据库(中国)》(JSTChina)收录期刊
  • 美国《乌利希期刊指南》(UIrichsweb)收录期刊
  • 中华预防医学会系列杂志优秀期刊(2019年)

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

hEXO1基因单核苷酸多态性与肝细胞癌的相关性研究

覃若云 谭盛葵 仇小强 谭超 刘柳 黄雄 李岸花 龙静铧 廖倩 杨筱筠

覃若云, 谭盛葵, 仇小强, 谭超, 刘柳, 黄雄, 李岸花, 龙静铧, 廖倩, 杨筱筠. hEXO1基因单核苷酸多态性与肝细胞癌的相关性研究[J]. 中华疾病控制杂志, 2016, 20(2): 116-120. doi: 10.16462/j.cnki.zhjbkz.2016.02.003
引用本文: 覃若云, 谭盛葵, 仇小强, 谭超, 刘柳, 黄雄, 李岸花, 龙静铧, 廖倩, 杨筱筠. hEXO1基因单核苷酸多态性与肝细胞癌的相关性研究[J]. 中华疾病控制杂志, 2016, 20(2): 116-120. doi: 10.16462/j.cnki.zhjbkz.2016.02.003
QIN Ruo-yun, TAN Sheng-kui, QIU Xiao-qiang, TAN Chao, LIU Liu, HUANG Xiong, LI An-hua, LONG Jing-hua, LIAO Qian, YANG Xiao-yun. Association of hEXO1 gene polymorphism with hepatocellular carcinoma[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 116-120. doi: 10.16462/j.cnki.zhjbkz.2016.02.003
Citation: QIN Ruo-yun, TAN Sheng-kui, QIU Xiao-qiang, TAN Chao, LIU Liu, HUANG Xiong, LI An-hua, LONG Jing-hua, LIAO Qian, YANG Xiao-yun. Association of hEXO1 gene polymorphism with hepatocellular carcinoma[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 116-120. doi: 10.16462/j.cnki.zhjbkz.2016.02.003

hEXO1基因单核苷酸多态性与肝细胞癌的相关性研究

doi: 10.16462/j.cnki.zhjbkz.2016.02.003
基金项目: 

国家自然科学基金(81160359);广西自然科学基金(2012GXNSFAA053149)

详细信息
    作者简介:

    覃若云(1989-),女,广西贵港人,在读硕士研究生。主要研究方向:慢性病流行病学。

  • 中图分类号: R730.267;R363.25

Association of hEXO1 gene polymorphism with hepatocellular carcinoma

  • 摘要: 目的 探讨肝细胞癌(hepatocellular carcinoma,HCC)遗传易感性与人类核酸外切酶1(human exonuclease 1,hEXO1)基因多态性的相关性。方法 应用病例对照方法,分别选取1 199例无HCC患者作为对照组,1 196例HCC患者作为病例组。选取hEXO1 基因的rs1047840、rs1776148位点进行基因分型,采取高通量 TaqMan MGB 实时荧光定量聚合酶链式反应(real-time fluorescent quantitative polymerase chain reaction,RT-PCR)进行基因分型。HCC 发病风险与位点rs1047840、rs1776148单核苷酸多态性(single nucleotide polymorphism,SNP)的相关性应用二分类Logistic 回归模型进行分析,同时研究吸烟、饮酒、乙型肝炎病毒(hepatitis B virus,HBV)感染等环境因素与位点rs1047840、rs1776148多态性的交互作用。结果 位点rs1047840、rs1776148基因型在对照组、病例组的分布差异均无统计学意义(均有P>0.05)。经分层分析,rs1047840、rs1776148与 HCC 发病风险均无统计学关联(均有P>0.05)。交互作用分析结果显示,位点rs1047840、rs1776148基因多态性与吸烟、饮酒、HBV 感染均存在交互作用。结论 饮酒、吸烟、HBV 感染等环境危险因素与rs1047840、rs1776148的交互作用可能与 HCC 发生有关。
  • Bosetti C, Turati F, La Vecchia C, et al. Hepatocellular carcinoma epidemiology [J]. Best Pract Res Clin Gastroenterol, 2014,28(5):753-770.
    Muro Y, Sugiura K, Mimor T, et al. DNA mismatch repair enzymes: genetic defects and autoimmunity [J]. Clin Chim Acta, 2015,442:102-109.
    Orans J, Mcsweeney EA, Iyer RR, et al. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family [J]. Cell, 2011,145(2):212-223.
    Nielsen FC, Jäger AC, Lützen A, et al. Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA [J]. Oncogene, 2004,23(7):1457-1468.
    Tishkoff DX, Amin NS, Viars CS, et al. Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination [J]. Cancer Res, 1998,58(22):5027-5031.
    Sun X, Zheng L, Shen B. Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome [J]. Cancer Res, 2002,62(21):6026-6030.
    Hansen LT, Thykjaer T, Ørntoft TF, et al. The role of mismatch repair in small-cell lung cancer cells [J]. Eur J Cancer, 2003,39(10):1456-1467.
    Thompson E, Meldrum CJ, Crooks R. Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations [J]. Clin Genet, 2003,65(3):215-225.
    Bak ST, Sakellariou D, Pena-Diaz J. The dual nature of mismatch repair as antimutator and mutator: for better or for worse [J]. Front Genet, 2014,5:287.
    Ladd PD, Wilson DM, Kelley MR. Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity [J]. DNA Repair (Amst), 2003,2(2):187-198
    Jäger AC, Rasmussen M, Bisgaard HC, et al. HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes [J]. Oncogene, 2001,20(27):3590-3595.
    Thompson E, Meldrum CJ, Crooks R, et al. Hereditary nonpolyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations[J]. Clin Genet, 2004,65(3): 215-225.
    Wu Y, Berends MJ, Post JG, et al. Germline mutations of Exo1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms [J]. Gastroenterology, 2001,120(7):1580-1587.
    Jin G, Wang H, Hu Z.Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: a case-control analysis [J]. Lung Cancer, 2008, 60(3): 340-346.
    谭盛葵,仇小强,余红平,等. 广西肝癌高发区原发性肝癌危险因素 Logistic 回归分析 [J]. 华夏医学, 2008,21(1):29-31.
    Miyata M, Morishita A, Sakamoto T, et al.MicroRNA profiles in cisplatin-induced apoptosis of hepatocellular carcinoma cells [J]. Int J Oncol, 2015,47(2):535-542.
  • 加载中
计量
  • 文章访问数:  345
  • HTML全文浏览量:  65
  • PDF下载量:  355
  • 被引次数: 0
出版历程
  • 收稿日期:  2015-11-03
  • 修回日期:  2016-01-02

目录

    /

    返回文章
    返回