Clinical study of 157 rheumatoid arthritis patients' combination and complication
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摘要: 目的 调查住院类风湿关节炎(rheumatoid arthritis,RA)患者合并症及并发症的临床特点并分析其影响因素。方法 回顾性分析157例住院RA患者的合并症及并发症,分析影响因素与合并症及并发症的相关性。结果 合并症及并发症总的发生率为84.71%。合并症主要为心血管系统82例(52.23%):高血压57例(36.31%)、冠心病18例(11.46%)及心律失常7例(4.46%);骨骼系统58例(36.94%):骨关节炎29例(18.47%)、骨质疏松25例(15.92%)、股骨头坏死4例(2.55%);消化系统14例(8.92%):胃炎10例(6.37%)、消化道溃疡4例(2.55%);并发症主要为血小板增高57例(36.31%)、贫血51例(32.48%)、低蛋白血症23例(14.65%)等。其他合并症及并发症包括高血脂46例(29.30%)、高血糖19例(12.10%)、肺部感染5例(3.18%)等。影响合并症和并发症发生的危险因素较多,如年龄、体重、总胆固醇等。其中总胆固醇和低密度脂蛋白的OR及其95% CI分别是20.87(4.78~91.15)、30.09(2.21~49.11)。结论 RA患者合并症及并发症高达84.71%。合并症中最多见的是心血管病变;并发症以血小板增高和贫血最常见。男性、高龄、长病程、体重和血沉等是其重要的危险因素。
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