Analysis on quality of life/patient-reported outcomes and their influence factors in patients with rheumatoid arthritis:applications of QLICD-RA(V2.0)
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摘要: 目的 探究影响类风湿关节炎患者生命质量/患者报告结局的因素,为提高患者生命质量提供科学依据。方法 应用类风湿关节炎生命质量测定量表(quality of life instruments for chronic diseases in rheumatoid arthritis (version 2.0),QLICD-RA(V 2.0))调查100例住院患者的生命质量,并记录临床相关客观指标。应用t检验、方差分析、多元逐步回归等统计学方法分析影响类风湿关节炎患者生命质量/患者报告结局的因素。结果 单因素分析中,不同文化程度和家庭经济状况的患者生命质量总分及各领域得分差异均有统计学意义(均有P<0.05)。多元逐步回归分析中,筛选出28关节中的关节肿胀得分(disease activity score-28,DAS28)、家庭经济状况(economy conditions, EC)和天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)与丙氨酸氨基转移酶(alanine aminotransferase,ALT)比值(AST/ALT)这3个变量进入回归方程,其回归方程为:Y=55.239-1.390DAS28+12.729EC-4.491AST/ALT,调整决定系数Ra2=0.558。结论 类风湿关节炎患者生命质量/患者报告结局受多种因素影响,缓解患者症状、提高经济水平对提高类风湿关节炎患者的生命质量/患者报告结局有重要意义。Abstract: Objective To analyze the quality of life/patient-reported outcomes and their influence factors in patients with rheumatoid arthritis for the establishment of related policies to improve the patients'quality of life. Methods The quality of life instruments for chronic diseases in rheumatoid arthritis (version 2.0)(QLICD-RA(V2.0)) was used to survey 100 in-patients with rheumatoid arthritis, and the clinical objective indicators were recorded. The influence factors of the quality of life or patient-reported outcomes were analyzed by methods of t-test, analysis of variance and multiple stepwise regression. Results In single factor analysis,the total and each domain score of quality of life among different education levels and the family economic conditions were significantly different (all P<0.05). In multiple factors analysis, disease activity score-28(DAS28), family economic conditions(EC) and aspartate aminotransferase(AST)/alanine aminotransferase(ALT) were selected into the regression equation: Y=55.239-1.390DAS28+12.729EC-4.491AST/ALT, and the adjusted coefficient of decision Ra2=0.558. Conclusions The quality of life/patient-reported outcomes were influenced by a number of factors. It is of significance to improve patients' quality of life by relieving symptoms and improving the level of economic.
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Key words:
- Arthritis, rheumatoid /
- Quality of life /
- Epidemiologic studies
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Rothman ML, Beltran P, Cappelleri JC, et al. Patient-reported outcomes:conceptual issues [J]. Value in Health, 2007,10(Suppl 2):S66-S75. 马艳,谭震,李向培,等. 病情稳定的类风湿关节炎患者临床症状与气象指标的相关研究 [J]. 中华疾病控制杂志, 2015,19(9):904-908. 栗占国,张奉春,鲍春德. 类风湿关节炎[M]. 北京:人民卫生出版社, 2009. 张灵芝,卢淑水. 类风湿关节炎病人生存质量影响因素分析 [J]. 护理研究, 2014,28(5C):1831-1832. Sadamoto K, Fukuya H, Saito E. What is the factor that most influences QOL among rheumatoid arthritis patients [J]. Mod Rheumatol, 2001,11(1):52-55. 戚艳波,孙松,万崇华,等. 类风湿性关节炎患者生命质量测定量表QLICD-RA研制中的条目筛选 [J]. 昆明医学院学报, 2009,30(10):5-9. 万崇华,张晓磬,李晓梅,等. 慢性病患者生命质量测定量表体系 QLICD 各量表的测量学特性分析 [J]. 昆明医学院学报, 2009,30(8):40-45. 孙素平,周青华. 类风湿关节炎生存质量评价研究进展 [J]. 辽宁中医药大学学报, 2011,13(1):24-26. Wan C, Tu X, Messing S, et al. Development and validation of the general module of the system of quality of life instruments for chronic diseases and its comparison with SF-36 [J]. J Pain Symptom Manage, 2011,42(1):93-104. Uguz F, Kucuk A,Cicek E, et al. Quality of life in rheumatologic patients:The impact of personality disorders [J]. Int J Psychiatry Med, 2015,49(3):199-207. 陈勇,陈志伟,黄华,等. SF-36量表用于类风湿关节炎患者生命质量的研究 [J]. 苏州大学学报(医学版), 2005,25(3):443-445. 杨佼佼,冯耀清,陈雪霞. 类风湿关节炎患者生活质量影响因素的调查研究 [J]. 教育教学论坛, 2014,(50):103-104. 吴炜戎,罗政,江东霖,等. 广州社区风湿病患者生命质量现状及影响因素的调查研究 [J]. 中国全科医学, 2014,17(21):2490-2494. 阮立云,顾岳全. 类风湿关节炎患者生命质量的随访研究 [J]. 现代实用医学, 2014,26(6):750-752. Bedi GS, Gupta N,Handa R, et al. Quality of life in Indian patients with rheumatoid arthritis [J]. Quality of Life Research, 2005,14(8):1953-1958. 罗蓉,李卓成,陈剑雄,等. 肝损害患者血清mAST/AST比值的动态变化及其临床意义 [J]. 热带医学杂志, 2008,8(6):567-569.
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