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可诱导共刺激分子配体在系统性红斑狼疮血清中水平及临床意义

萧健萍 周强 张森 贺文涛 王雪荣 潘海峰 王德光

萧健萍, 周强, 张森, 贺文涛, 王雪荣, 潘海峰, 王德光. 可诱导共刺激分子配体在系统性红斑狼疮血清中水平及临床意义[J]. 中华疾病控制杂志, 2016, 20(10): 999-1003. doi: 10.16462/j.cnki.zhjbkz.2016.10.008
引用本文: 萧健萍, 周强, 张森, 贺文涛, 王雪荣, 潘海峰, 王德光. 可诱导共刺激分子配体在系统性红斑狼疮血清中水平及临床意义[J]. 中华疾病控制杂志, 2016, 20(10): 999-1003. doi: 10.16462/j.cnki.zhjbkz.2016.10.008
XIAO Jian-ping, ZHOU Qiang, ZHANG Sen, HE Wen-tao, WANG Xue-rong, PAN Hai-feng, WANG De-guang. Serum levels and clinical significance of soluble ICOSL in patients with systemic lupus erythematosus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(10): 999-1003. doi: 10.16462/j.cnki.zhjbkz.2016.10.008
Citation: XIAO Jian-ping, ZHOU Qiang, ZHANG Sen, HE Wen-tao, WANG Xue-rong, PAN Hai-feng, WANG De-guang. Serum levels and clinical significance of soluble ICOSL in patients with systemic lupus erythematosus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(10): 999-1003. doi: 10.16462/j.cnki.zhjbkz.2016.10.008

可诱导共刺激分子配体在系统性红斑狼疮血清中水平及临床意义

doi: 10.16462/j.cnki.zhjbkz.2016.10.008
基金项目: 

中国博士后科学基金(2012M511399);安徽省自然科学基金(1508085MH148);安徽省博士后科学基金(9101019202)

详细信息
    作者简介:

    萧健萍(1990-),女,安徽宿州人,在读硕士研究生。主要研究方向:系统性红斑狼疮。

  • 中图分类号: R593.24

Serum levels and clinical significance of soluble ICOSL in patients with systemic lupus erythematosus

  • 摘要: 目的 探讨可诱导共刺激分子配体(inducible costimulator molecule ligand,ICOSL)在系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清表达水平变化,并分析其临床意义。方法 纳入2015年3月1日~2015年8月31日安徽医科大学第一附属医院、第二附属医院的风湿科和肾脏科住院治疗的34例活动性SLE、15例非活动性SLE患者和33例年龄、性别相匹配的健康志愿者,酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)法检测血清标本可溶性ICOSL(sICOSL)水平。结果 与健康对照组相比,SLE、狼疮肾炎(lupus nephritis,LN)、活动组血清sICOSL水平降低(P1=0.004;P2=0.008;P3=0.003);但血清sICOSL水平与SLE疾病活动度、anti-dsDNA滴度、补体C3、补体C4、血沉、24小时尿蛋白、血肌酐、尿素氮均无相关性(均有P>0.05),并且实验室指标阳性组与阴性组sICOSL的血清水平差异均无统计学意义(均有P>0.05)。此外,糖皮质激素或者免疫抑制剂的应用并未对血清sICOSL水平产生影响(t=-0.69,P=0.495)。结论 SLE患者血清ICOSL表达水平降低,提示其可能参与了SLE的发生、发展,但其具体机制尚未明确,需要进一步研究。
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出版历程
  • 收稿日期:  2016-05-19
  • 修回日期:  2016-08-27

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