Analysis on the epidemiological and etiological characteristics of clustered cases of hand, foot, and mouth disease in Wuxi from 2009 to 2014
-
摘要: 目的 了解无锡市2009-2014年手足口病聚集性疫情的流行特征,为制定手足口病防控措施提供科学依据。方法 收集2009-2014年无锡市手足口病聚集性疫情信息,应用描述流行病学方法分析三间分布特征。结果 2009-2014年无锡市共报告手足口病聚集性疫情1 035起,累积报告病例4 959例,占同期总发病人数的6.2%(4 959/79 571),其中12起符合突发公共卫生事件标准;聚集疫情每年发病高峰在4~6月和11月;聚集性疫情和病例数均集中在城乡结合部,主要发生在托幼机构77.6%(803/1 035),且地区间托幼场所发生频次分布差异有统计学意义(χ2=128.21,P<0.001);疫情发生后1 d内报告的占21.3%(220/1 035),罹患率为0.02%~100.00%,中位数为1.6%,疫情持续时间1~46 d,中位数为4.0 d;疫情发生报告间隔与疫情持续时间及发病人数均呈正相关(均有P<0.001)。共采集病例标本阳性率为42.2%(1 008/2 389),阳性标本中以EV71型(45.3%)和CoxA16(40.1%)为主。结论 无锡地区城乡结合部的托幼机构是手足口病聚集性疫情高发场所,应加大对托幼机构的监管,可以有效防控手足口病暴发疫情。Abstract: Objective To ascertain the epidemiological characteristics of clustered cases of hand, foot and mouth disease (HFMD) in Wuxi, and to provide scientific basis for the prevention and control of HFMD. Methods Data on clustered cases of HFMD in Wuxi from 2009 to 2014 was collected to conduct descriptive analysis. Results From January 2009 to December 2014, 1 035 HFMD outbreaks affecting 4 959 individuals which accounting for 6.2% of all cases of HFMD were reported in Wuxi, in which 12 were classified as public health emergencies. The annual incidence peak of HFMD occurred during April to June, and sub-peak occurred in November. The majority of outbreaks (48.7%) and cases (48.0%) were concentrated in rural-urban continuum. Up to 77.6% of outbreaks occurred in kindergartens. The occurrence frequency in different districts of kindergartens showed statistical difference (χ2=128.21,P<0.001). A total of 220 outbreaks (21.3%) were reported within one day. The attack rate of which ranged from 0.02% to 100.00% (median: 1.6%), and the durations ranged from one to 46 days (median: 4 days). Correlation analysis indicated that non-timely reporting was positively related with the duration and cases number of the outbreak significantly (all P<0.001), with r value of 0. 627 and 0.219 respectively. Of all cases, 2 389 samples were tested, the positive rate was 42.2% (1 008/2 389). The tests indicated intestinal virus EV71 (45.3%) and CoxA16 (40.1%) were the two dominated types in positive samples. Conclusions Kindergartens of rural-urban continuum are areas with a prevalence of clustered cases of HFMD. Clustered cases of HFMD can be effectively controlled by enhancing surveillance in these kindergartens.
-
Key words:
- Hand, foot and mouth disease /
- Disease outbreaks /
- Epidemiologic methods
-
Wang Y, Feng Z, Yang Y, et al. Hand, foot, and mouth disease in China: patterns of spread and transmissibility[J]. Epidemiology, 2011,22(6):781-792. Chang LY, King CC, Hsu KH, et al. Risk factors of enterovirus 71 infection and associated hand,foot,and mouth disease/herpangina in children during an epidemic in Taiwan[J]. Pediatrics, 2002,109(6): e88. Chang LY, Tsao KC, Hsia SH, et al. Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan[J]. JAMA, 2004,291(2):222-227. 石平,钱燕华,缪小兰,等. 无锡市2009年手足口病流行特征及病原学监测分析[J]. 中国公共卫生, 2010,26(12):1539-1541. 贺天锋,许国章,易波,等. 宁波市2007-2010年托幼机构手足口病流行特征分析[J]. 中国学校卫生, 2011,32(9):1089-1090. 赵志荣,姚为玲,陈瑾,等. 2010~2011年马鞍山市手足口病聚集性疫情流行特征分析[J]. 中国病原生物学杂志, 2013,8(2):164-166. Onozuka D, Hashizume M. The influence of temperature and humidity on the incidence of hand, foot, and mouth disease in Japan[J]. Sci Total Environ, 2011,410-411:119-125. Deng T, Huang Y, Yu S, et al. Spatial-temporal clusters and risk factors of hand, foot, and mouth disease at the district level in Guangdong Province, China[J]. PLoS One, 2013, 8(2):e56943. Cheng J, Wu J, Xu Z, et al. Associations between extreme precipitation and childhood hand, foot and mouth disease in urban and rural areas in Hefei, China[J]. Sci Total Environ, 2014,497-498:484-490. 贾蕾,李锡太,曲梅,等. 2009年北京市手足口病聚集性病例流行病学分析[J]. 中华疾病控制杂志, 2011,15(4):312-314. 王联君,高洪,汪静,等. 27起手足口病聚集性疫情的流行病学分析[J]. 现代预防医学, 2013,40(9):1601-1604. 王娅琼,杨育松,王化勇,等. 2011年密云县手足口病聚集性疫情分析[J]. 预防医学情报杂志, 2013,29(2):126-128. 张春道,营亮. 连云港市2010-2011年手足口病聚集性疫情流行特征分析[J]. 江苏预防医学, 2013,24(1):23-25. 张进,史永林,吴家兵,等. 安徽省2008-2012年手足口病流行病学及病原学特征分析[J]. 中华疾病控制杂志, 2014,18(6):497-500 王静,徐敏钢,李恩国,等. 上海市闸北区手足口病聚集性疫情流行病学特征分析[J]. 现代预防医学, 2013,40(14):2577-2580.
点击查看大图
计量
- 文章访问数: 373
- HTML全文浏览量: 87
- PDF下载量: 3
- 被引次数: 0