Risk factors of multidrug-resistant tuberculosis in Anhui Province: A case-control study
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摘要: 目的 探讨安徽省耐多药肺结核的危险因素。方法 采用病例对照研究方法,病例组为83名耐多药肺结核病人,对照组为98名已治愈的非耐药肺结核病人,以问卷调查形式收集资料。结果 居住地为农村、文化程度为初中及以下、家庭人均月收入少、外出务工、吸烟、服用抗结核药物产生不良反应、既往抗肺结核治疗次数多、既往有某个疗程中暂时停药或暂时中断治疗、首次确诊时X线检查肺内病灶多、空洞多、首次抗结核治疗效果未治愈都是耐多药肺结核的危险因素(均有P<0.05);病人接受过结核病知识以及治疗过程中有关服药原则的宣传和教育、>7 h的睡眠时间是耐多药肺结核的保护因素(均有P<0.05)。结论 导致安徽省耐多药肺结核发生的危险因素较多,适当的宣传教育和充足的睡眠有助于减少耐多药肺结核的发生。Abstract: Objective To investigate the risk factors of multidrug-resistant tuberculosis in Anhui Province. Methods 83 patients with multidrug-resistant pulmonary tuberculosis and 98 cured patients with non drug-resistant pulmonary tuberculosis were collected and analyzed with case-control study. Results Rural residence, junior high school education level and below, less family month income, migrant work, smoking, experience of adverse reactions of anti-tuberculosis drugs, history of repeated tuberculosis treatment, history of discontinuation or temporary interruption of anti-tuberculosis therapy, lung X ray image with multiple lesions or cavities when tuberculosis was diagnosed, and once first treatment failure were risk factors of multidrug-resistant tuberculosis (all P<0.05); equipped with tuberculosis knowledge or related medication taking principle popularization and sleeping time >7 hours were protective factors (all P<0.05). Conclusions The risk factors of multidrug-resistance tuberculosis in Anhui Province are various. Adequate tuberculosis education and sufficient sleep might be beneficial to the disease.
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