Abstract: Objective To investigate clinicians' knowledge, attitude and practice (KAP) about ethical review and to provide reference data for hospital research ethics management. Methods Using random sampling method stratified by professional titles, 211 clinicians in a first class hospital in Beijing were investigated by self-developed questionnaire. Descriptive analysis was completed by SPSS 20.0 software. Results There were 76(36.0%) in 211 clinicians clearly knew the basic requirements and application process of ethical review and 171(81.0%) of the 211 were in favor of ethical review about biomedical research involving human. 134(71.7%) of the 187 clinicians who involved in medical research involving human could take the initiative to apply for ethics review. Conclusions Most clinicians think that medical research involving human subjects should be ethically reviewed. But the specific ethical review requirements and processes are inadequate understanding. The initiative of applying ethical review has yet to be improved.