Analysis on associated risk factors of post-stroke epilepsy
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摘要: 目的 分析脑卒中后癫痫发作的临床特点,并对其相关因素进行分析。方法 对1 008例脑卒中患者进行回顾性研究,并分析可能影响卒中后继发癫痫发作的相关危险因素。结果 脑卒中后癫痫发作的发生率约为5.36%,其中早发型癫痫占63.11%,发作类型以单纯部分发作为主,迟发型癫痫占38.89%,发作类型以全身强直-阵挛发作为主,单因素分析结果显示:性别(χ2=4.12,P=0.042)、糖尿病(χ2=4.89,P=0.027)、肺部感染(χ2=8.95,P=0.003)、病灶部位(χ2=45.14,P<0.001)和病灶范围(χ2=23.32,P<0.001)与卒中后癫痫发作有关;多元Logistic分析结果显示:性别(OR=1.946,95%CI:1.039~3.644)、肺部感染(OR=3.618,95%CI:1.536~8.520)、病灶部位(OR=6.435,95%CI:3.353~12.349)和病灶范围(OR=2.513,95%CI:1.374~4.599)等因素可能与卒中后癫痫发作有关(均有P<0.05)。结论 男性,肺部有感染,病灶部位在皮质和病灶范围大可能是卒中后癫痫发作的危险因素。Abstract: Objective To study the clinical characteristics of post-stroke epilepsy and analyze the related risk factors of epilepsy onset after stroke. Methods A retrospective study was conducted among 1 008 stroke patients in our hospital and the related risk factors for epilepsy onset secondary to stroke were analyzed. Results The incidence of epilepsy after stroke was 5.36%, among which 63.11% was early-onset epilepsy, and simple partial seizure was the predominant seizure type. But only 38.89% was late-onset epilepsy and the seizure type was mainly generalized tonic-clonic seizures. Univariate analysis showed that gender (χ2=4.12, P=0.042), diabetes (χ2=4.89, P=0.027), pulmonary infection (χ2=8.95, P=0.003), lesion location (χ2=45.14,P<0.001) and scope of lesions (χ2=23.32, P<0.001) were associated with seizures after stroke; Multivariate Logistic analysis showed that gender (OR=1.946, 95% CI:1.039-3.644), pulmonary infection (OR=3.618,95% CI:1.536-8.520), lesion location (OR=6.435, 95% CI:3.353-12.349) and scope of lesions (OR=2.513,95% CI:1.374-4.599) were more prone to seizures after stroke (all P<0.05). Conclusions Males, pulmonary infection, lesion location in cortex and the bigger scope of lesions may be the risk factors of secondary epilepsy after stroke.
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Key words:
- Stroke /
- Epilepsy /
- Risk factors /
- Epidemiologic methods
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