Association of resting heart rate and risk of type 2 diabetes mellitus: a Meta-analysis
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摘要: 目的 系统评价静息心率与2型糖尿病发病风险的关系。方法 通过检索中国知网、万方、PubMed和Web of Science数据库,查找关于静息心率与2型糖尿病发病风险的队列研究,按照严格的纳入排除标准筛选文献、提取数据并进行质量评价,运用Stata 11.0软件对纳入的文献进行综合分析,并按种族、静息心率测量方法、随访时间、样本量对文献进行亚组分析。结果 共纳入11篇队列研究文献,总样本量为212 891人。分析结果显示,与静息心率最低分类组相比,静息心率最高分类组人群2型糖尿病发病风险的合并效应值RR=1.54,95% CI:1.29~1.84,亚组分析结果显示,亚洲人和高加索人2型糖尿病发病风险分别为1.67(1.38~2.03)和1.29(1.02~1.62)。Begg's检验(P=0.350)和Egger's检验(P=0.662)未发现发表偏倚。结论 静息心率升高可以增加2型糖尿病发病风险,提示控制静息心率能够降低2型糖尿病的发病风险。Abstract: Objective To explore the relationship between resting heart rate and risk of type 2 diabetes mellitus (T2DM). Methods China National Knowledge Infrastructure, WANFANG DATA, PubMed and Web of Science were searched to acquire the studies concentrating on resting heart rate and T2DM risk. All the studies were screened according to the inclusion and exclusion criteria. Quality of the studies was evaluated and data were extracted. The meta-analysis were performed with Stata 11.0. Subgroup analyses concentrating on race, the measurement method of resting heart rate, follow-up time and the sample size were conducted to explore the heterogeneity sources. Results A total of 11 prospective cohort studies were included and the whole sample size was 212 891. Compared to the lowest resting heart rate group, the pooled relative risk of T2DM in the highest group was 1.54 (1.29-1.84). Subgroup analysis showed that the risk of T2DM were 1.67 (1.38-2.03) for the Asian and 1.29 (1.02-1.62) for the Caucasian, respectively. According to the Begg's test (P=0.350) and Egger's test (P=0.662), no publication bias was observed. Conclusions Elevated resting heart rate can increase the risk of T2DM and it also indicate that the risk of T2DM could be decreased by controlling resting heart rate.
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Key words:
- Heart rate /
- Diabetes mellitus, type 2 /
- Cohort studies /
- Meta-analysis
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