Abstract: Objective To explore the effect and feasibility of comprehensive interventions majoring in healthy diet, physical activity, smoking cessation and appropriate alcohol use for patients with metabolic syndrome (MS). Methods Patients who work in the government organizations and institutions diagnosed with MS according to the International Diabetes Federation Criteria were included in the study and given intervention for 12 months. All patients received relevant health courses every 2 months. Intervention group patients received additional comprehensive interventions including healthy diet, physical activity, smoking cessation and appropriate alcohol use with self-management method. Physical examination and biochemical indicators testing were performed before, 6 months and 12 months after the intervention respectively. Questionnaire investigations on MS related knowledge were implemented before and after the intervention. Results MS related knowledge awareness rate was higher in intervention group than control group after 12 month intervention. Intervention group patients' body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride, total cholesterol, low-density lipoprotein cholesterol, fasting plasma glucose levels and high-density lipoprotein cholesterol level were significantly different with control group (all P<0.05). Conclusions Comprehensive intervention measures majoring in healthy diet, physical activity, smoking cessation and appropriate alcohol use are effective for MS patients.