Abstract: Objective To analyze the epidemic characteristics of hemorrhagic fever with renal syndrome (HFRS) in Jiangsu Province, 2011-2016. Methods Retrospective analysis was carried on surveillance data of HFRS in National Diseases Reporting Information System with descriptive epidemiological method and retrospective space-time permutation scan statistics. Results A total of 1 733 cases were reported in Jiangsu Province, 2011-2016, with an average annual incidence of 0.36 per 100 000.The proportion of male to female was 1:0.30. 40-and 50-age groups were with higher incidence. Peasants accounted for 78.71% of the total cases and the proportion of household and unemployment were rising year by year(χ_trend²=4.446, P=0.035). Northern area of Jiangsu was with the highest incidence and a bimodal seasonal case distribution,with first peak occurring from October to January of next year and the second occurring from April to June. The spatial-temporal distribution of HFRS showed a certain character of space-time clustering by county and 5 clusters were detected. Conclusions The incidence of HFRS has increased from time to time since the 21st century. The epidemic intensity and temporal-spatial cluster in northern Jiangsu were different from those in Southern. Specific control and prevention measures should be further conducted in high-risk areas.