Abstract: Epigenetic signatures can be modified in response to environmental influence. All of epigenetic markers can be almost erased by a two-step epigenome reprogramming progress during early development. However, epigenetic information and related phenotype occur in the absence of direct environmental exposure. It is called epigenetic transgenerational inheritance. Further study of epigenetic transgenerational inheritance will help us realize the profound influence of environmental factors on human health, and develop effective measures to prevent us from hazards. In this comment, we focus on epigenetic transgenerational inheritance and environmental stress and discuss the future of this area.