Abstract: Objective To analyze the epidemiology and temporal-spatial clusters of bacillary dysentery in Chongqing from 2005 to 2015. Methods The monitoring data of bacillary dysentery in 38 regions were collected from 2005 to 2015, ArcGIS 10.2 software was employed to draw the spatial distribution map of bacillary dysentery incidence, OpenGeoda 1.2.0 was used to analyze the spatial correlation of bacillary dysentery incidence. Temporal-spatial clustering was employed by SaTScan 9.4.2. Results The annual incidence rate was 31.84/100 000 population from 2005 to 2015,with higher prevalence (43.7%) among people aged 1 to 5 years, the majority of bacillary dysentery cases were scattered children(41.75%). The peak season was between May and October. The bacillary dysentery incidence showed a spatial autocorrelation during study period, high-high clusters distributed in main urban districts, low-low clusters presented in the one-hour economic circle and Northeast Area. The temporal-spatial clustering analysis revealed that bacillary dysentery clusters most likely occurred in main urban districts from June to October. Conclusions The bacillary dysentery incidence present temporal-spatial clusters feature, and the prevention and control measures should be implemented in summer and fall and focused on main urban districts. Children, farmer and migrant workers are the key population to control the spread of bacillary dysentery.