Abstract: Objective To investigate the relationship between age and triglyceride and the effect of their interaction on elderly patients with impaired fasting glucose (IFG). Methods From July to November 2012, 3 492 people aged ≥ 45 years old were enrolled in the physical examination population in the Affiliated of Guilin Medical College. A total of 378 patients with IFG were selected and included in the case group, whereas 374 gender-and age-matched subjects who had normal glucose were included in the control group. The metabolic characteristics of the two groups were compared and analysed. Logistic regression model was used to study the independent effects of risk factors, and the interaction between risk factors was analyzed by additive model and multiplicative model. Results The levels of systolic blood pressure, diastolic blood pressure, body mass index, fasting blood glucose, uric acid, triglyceride, total cholesterol, low density lipoprotein-cholesterol in IFG patients were higher than those in control group, while high density lipoprotein-cholesterol decreased in patients with IFG, the difference was statistically significant(all P<0.05). After adjusting some confounding factors, multivariate Logistic regression analysis showed that people aged ≥ 60 years and with high triglyceride had a 3.513 times higher risk of IFG than those aged <60 years and with normal triglyceride(OR=3.513, 95% CI:2.360-5.230). Interaction analysis of risk factors for IFG elderly showed that there was no multiplicative interaction between age ≥ 60 years and high triglycerides, but with additive interaction, the relative excess risk due to interaction (RERI) was 0.91, the attributable proportion due to interaction (AP) was 25.90% and the synergy index (S) was 1.57. Conclusions There are several metabolic syndromes in individuals with IFG. The positive interaction between advanced age and triglyceride are among the important risk factors for IFG patients, both of which can significantly increase the risk of illness.