2015―2021年陕西省丙型病毒性肝炎流行特征和空间聚集性

宁少奇; 刘晨越; 胡丹妮; 曹磊; 陈飒; 张路钱; 年云鹏; 张义

doi:10.16462/j.cnki.zhjbkz.2023.08.019

2015―2021年陕西省丙型病毒性肝炎流行特征和空间聚集性

doi: 10.16462/j.cnki.zhjbkz.2023.08.019

1.
陕西省疾病预防控制中心传染病预防控制所，西安 710054
2.
西安交通大学医学部临床医学专业，西安 710061
3.
西安医学院第一附属医院影像科，西安 710054

基金项目:

渭南市华州区丙型肝炎的危险因素及防制策略研究 2018ZDXM-SF-058

陕西省卫生应急作业平台建设项目 2020PT-030

详细信息

通讯作者:
张义，E-mail: 8826970@qq.com

中图分类号: R51;R181
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- 文章访问数: 293
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- 被引次数: 0
出版历程
- 收稿日期: 2022-07-22
- 修回日期: 2022-11-28
- 网络出版日期: 2023-09-02
- 刊出日期: 2023-08-10

Epidemiological characteristics and spatial clustering analysis of hepatitis C in Shaanxi Province from 2015 to 2021

1.
Shaanxi Provincial Centre for Disease Control and Prevention Institute for Infectious Disease Prevention and Control, Xi′an 710054 China
2.
Department of Clinical Medicine, Xi′an Jiaotong University Health Science Center, Xi′an 710061 China
3.
The First Affiliated Hospital of Xi′an Medical University Imaging Department, Xi′an 710054 China

Funds:

Risk Factors and Prevention Strategies of Hepatitis C in Huazhou District, Weinan City 2018ZDXM-SF-058

Shaanxi Province Health Emergency Operations Center Project 2020PT-030

More Information

Corresponding author: ZHANG Yi, E-mail: 8826970@qq.com

摘要

摘要: 目的对陕西省丙型病毒性肝炎(丙肝)的流行特征和空间聚集性进行分析，为重点区域及重点人群的防控提供科学依据。方法收集2015―2021年陕西省丙肝报告病例资料，对数据进行查重。采用描述性流行病学分析其三间分布特征，使用R4.0.4和GeoDa1.6软件进行全局和局部空间聚集性分析。结果 2015―2021年陕西省报告丙肝发病率呈总体下降趋势(χ_趋势²=590.919, P < 0.001)。男女性别比为1.06∶1，40~＜70岁年龄组报告病例数较多，职业以农民、家务及待业、离退休人员为主。全局自相关分析发现2016、2017、2018、2019、2021年Moran's I系数均为正值(均P＜0.05);热点分析发现，丙肝发病高聚集区域2016年(12个)、2017年(14个)、2018年(12个)、2019年(9个)、2021年(8个)主要集中于关中的中部和东部地区。结论陕西省丙肝发病存在人群异质性和地区聚集性，应加强重点人群和地区的疫情监测、健康教育，提高整体防护意识，提供医疗援助并尽早控制传染源。
- 丙型病毒性肝炎 /
- 流行特征 /
- 空间聚集性分析
Abstract: Objective To analyze the epidemic characteristics and spatial aggregation of the hepatitis C virus in Shaanxi Province, thereby offering scientific evidence for the prevention and control. Methods We collected data on Hepatitis C virus infection cases in Shaanxi Province from 2015 to 2021, eliminating duplicate cases. The distribution characteristics were analyzed by descriptive epidemiological study, R 4.0.4 and GeoDa 1.6 software was used to conduct spatial statistical analyses.Results The reported incidence in Shaanxi Province from 2015 to 2021 showed an overall downward trend (χ²=590.919, P < 0.001). The male-to-female ratio was 1.06∶1, with the majority of reported cases found in the 40- < 70 age group. The primary occupations of these infected were farmers, housework, unemployed individuals and retirees. Global autocorrelation analysis found positive Moran's I coefficients in 2016, 2017, 2018, 2019, and 2021 (all P < 0.05). Hot Spot analysis identified high concentration areas of hepatitis C virus in 2016 (12), 2017 (14), 2018 (12), 2019 (9), 2021 (8), which were mainly concentrated in the central and eastern regions of Guanzhong. Conclusions The incidence of Hepatitis C virus in Shaanxi Province displays distinct population characteristics and regional clustering. Therefore, we should enhance epidemic surveillance and health education among high-risk populations and key regions, improve overall protective awareness, and provide medical assistance to control the infection source as early as possible.
- Hepatitis C /
- Epidemiologic characteristic /
- Spatial aggregation analysis

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图 1 2015―2021年陕西省丙肝发病的时间分布情况

Figure 1. Temporal distribution of hepatitis C in Shaanxi Province from 2015 to 2021

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图 2 2015―2021年陕西省丙肝病例的年龄分性别分布情况

Figure 2. Age and sex distribution of hepatitis C in Shaanxi Province from 2015 to 2021

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图 3 2015―2021年陕西省丙肝报告发病率排名前5位县(区)发病情况

Figure 3. Incidence of hepatitis C in the top five counties (districts) in Shaanxi Province in 2015-2021

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图 4 2015―2021年陕西省丙肝发病热点区域分布

Figure 4. Regional distribution of hot-spots of hepatitis C in Shaanxi Province from 2015 to 2021

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表 1 2015―2021年陕西省丙肝发病概况

Table 1. Incidence of hepatitis C in Shaanxi Province from 2015 to 2021

年份 Year	发病率/10万^-1 Incidence ratio/100 000^-1	男性发病率/10万^-1 Male incidence ratio/100 000^-1	女性发病率/10万^-1 Female incidence ratio/100 000^-1	男女性别发病比 Incidence ratio of male to female
2015	20.91	21.65	20.13	1.08∶1
2016	21.72	22.08	21.34	1.03∶1
2017	22.72	22.85	22.58	1.01∶1
2018	22.04	23.04	20.98	1.10∶1
2019	21.32	21.66	20.95	1.03∶1
2020	17.15	17.67	16.61	1.06∶1
2021	15.39	16.16	14.58	1.11∶1

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表 2 2015―2021年陕西省丙肝发病全局空间自相关分析结果

Table 2. Global spatial autocorrelation analysis on hepatitis C in Shaanxi Province from 2015 to 2021

年份 Year	莫兰指数 Moran′s I	预期指数 Expectation index	方差 Variance	Z值 value	P值 value	结果 Result
2015	0.048 5	-0.009 0	0.003 8	0.937 2	0.348 7	随机Random
2016	0.142 5	-0.009 0	0.003 8	2.455 7	0.014 1	聚集Clustered
2017	0.190 8	-0.009 0	0.003 8	3.288 8	0.001 0	聚集Clustered
2018	0.201 6	-0.009 0	0.003 8	3.454 4	0.000 6	聚集Clustered
2019	0.119 5	-0.009 0	0.003 8	2.240 0	0.025 1	聚集Clustered
2020	0.084 3	-0.009 0	0.00 38	1.948 0	0.051 4	随机Random
2021	0.156 2	-0.009 0	0.003 8	3.042 2	0.002 3	聚集Clustered

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表 3 2015―2021年陕西省丙肝发病的热点区域

Table 3. Hot spots of hepatitis C in Shaanxi Province from 2015 to 2021

年份 Year	热点个数/个 Number of Hot spot/no.	热点区域 Hot spot region
2016	12	高陵区、国际港务区、未央区、灞桥区、新城区、蓝田县、渭南市经开区、临潼区、莲湖区、碑林区、雁塔区、洛南县 Gaoling District、Xi′an International Trade & Logistics Park、Weiyang District、Baqiao District、Xincheng District、LanTian County、Weinan Economic Development Zone、Lintong district、Lianhu District、Beilin District、Yanta District、Luonan County
2017	14	高陵区、国际港务区、未央区、灞桥区、蓝田县、鄠邑区、渭南市经开区、兴平市、西咸新区、莲湖区、新城区、雁塔区、临潼区、洛南县 Gaoling District、Xi′an International Trade & Logistics Park、Weiyang District、Baqiao District、LanTian County、Huyi District、Weinan Economic Development Zone、Xingping City、Xixian New Area、Lianhu District、Xincheng District、Yanta District、Lintong district、Luonan County
2018	12	高陵区、国际港务区、未央区、灞桥区、新城区、蓝田县、渭南市经开区、洛南县、渭城区、鄠邑区、莲湖区、雁塔区 Gaoling District、Xi′an International Trade & Logistics Park、Weiyang District、Baqiao District、Xincheng District、LanTian County、Weinan Economic Development Zone、Luonan County、Weicheng District、Huyi District、Lianhu District、Yanta District
2019	9	未央区、国际港务区、灞桥区、蓝田县、洛南县、高陵区、商州区、丹凤县、山阳县 Weiyang District、Xi′an International Trade & Logistics Park、Baqiao District、LanTian County、Luonan County、Gaoling District、Shangzhou District、Danfeng County、Shanyang County
2021	8	西咸新区、雁塔区、鄠邑区、西安市高新区、淳化县、周至县、长安区、彬州市 Xixian New Area、Yanta District、Huyi District、Xi′an Hi-tech Industries Development Zone、Chunhua County town、Zhouzhi County、Changan District、Binzhou City

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