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不同年龄段生活方式对脑卒中影响的差异研究

王静茹 姜永根 吴毅凌 苏旭燕 谢旖婧 张彭燕 夏丁 赵琦 徐珂琳 张铁军 陈兴栋 赵根明 蒋艳峰 索晨

王静茹, 姜永根, 吴毅凌, 苏旭燕, 谢旖婧, 张彭燕, 夏丁, 赵琦, 徐珂琳, 张铁军, 陈兴栋, 赵根明, 蒋艳峰, 索晨. 不同年龄段生活方式对脑卒中影响的差异研究[J]. 中华疾病控制杂志, 2024, 28(1): 1-7. doi: 10.16462/j.cnki.zhjbkz.2024.01.001
引用本文: 王静茹, 姜永根, 吴毅凌, 苏旭燕, 谢旖婧, 张彭燕, 夏丁, 赵琦, 徐珂琳, 张铁军, 陈兴栋, 赵根明, 蒋艳峰, 索晨. 不同年龄段生活方式对脑卒中影响的差异研究[J]. 中华疾病控制杂志, 2024, 28(1): 1-7. doi: 10.16462/j.cnki.zhjbkz.2024.01.001
WANG Jingru, JIANG Yonggen, WU Yiling, SU Xuyan, XIE Yijing, ZHANG Pengyan, XIA Ding, ZHAO Qi, XU Kelin, ZHNAG Tiejun, CHEN Xingdong, ZHAO Genming, JIANG Yanfeng, SUO Chen. Age-related differences in the role of lifestyle for stroke[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 1-7. doi: 10.16462/j.cnki.zhjbkz.2024.01.001
Citation: WANG Jingru, JIANG Yonggen, WU Yiling, SU Xuyan, XIE Yijing, ZHANG Pengyan, XIA Ding, ZHAO Qi, XU Kelin, ZHNAG Tiejun, CHEN Xingdong, ZHAO Genming, JIANG Yanfeng, SUO Chen. Age-related differences in the role of lifestyle for stroke[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 1-7. doi: 10.16462/j.cnki.zhjbkz.2024.01.001

不同年龄段生活方式对脑卒中影响的差异研究

doi: 10.16462/j.cnki.zhjbkz.2024.01.001
基金项目: 

国家重点研发计划项目 2021YFC2500104

江苏省重点研发计划项目 BE2021696

国家重点研发计划“精准医学研究”重点专项 2017YFC0907000

详细信息
    通讯作者:

    索晨,E-mail:suochen@fudan.edu.cn

  • 中图分类号: R181.3

Age-related differences in the role of lifestyle for stroke

Funds: 

National Key Research and Development Program of China 2021YFC2500104

Key Research and Development Plans of Jiangsu Province, China BE2021696

"Precision Medicine Research" Key Project, National Key Research and Development Program of China 2017YFC0907000

More Information
  • 摘要:   目的  探讨上海市松江区居民生活方式对脑卒中风险的影响在不同年龄段中是否存在差异。  方法  选取上海郊区自然人群队列和生物样本库中松江区的31 771名研究对象,计算其健康生活方式评分(包括不吸烟、积极体育锻炼、均衡膳食和正常体重),并随访至2021年12月31日。分别采用Cox比例风险回归和泊松回归评估不同基线年龄组和暴露年龄组中不同的生活方式或健康生活方式评分与新发脑卒中的HR值(95% CI)和RR值(95% CI)。基线年龄分层:年轻组(20~<62岁)、中年组(62~<68岁)以及老年组(≥68岁)。暴露年龄分层:年轻组(20~<65岁)、中年组(65~<70岁)以及老年组(≥70岁)。  结果  在5.0年的中位随访时间内共新发488例脑卒中事件。控制混杂变量后,两种方法都未发现不吸烟、积极体育锻炼、均衡膳食和正常体重与脑卒中发病风险的关联在不同的年龄组有显著差异。与基线生活方式评分≤1分组相比,年轻组、中年组及老年组中评分≥3分组的新发脑卒中风险较低(HR=0.67, 95% CI: 0.43~1.03, P=0.072; HR=0.59, 95% CI: 0.39~0.91, P=0.015; HR=0.64, 95% CI: 0.42~1.00, P=0.043和RR=0.63, 95% CI: 0.42~0.96, P=0.028; RR =0.61, 95% CI: 0.40~0.94, P=0.023; RR=0.63, 95% CI: 0.40~0.99, P=0.045)。  结论  在上海市松江区居民中没有发现不同的生活方式与脑卒中的关联存在年龄差异。提示在任何年龄阶段都应重视健康的生活方式。当整体的生活方式比较健康时可大幅度降低脑卒中发病风险。
  • 图  1  不同年龄段中不同健康生活方式与脑卒中风险的关联

    Cox比例风险回归和泊松回归分别评估了各年龄组(年轻组:Y,中年组:M,老年组:O)中的不同健康生活方式与脑卒中的HRRR值。模型1调整了年龄和性别(绿色表示)。模型2调整年龄、性别、受教育年限、婚姻状况、脑卒中家族史、是否有高血压、糖尿病或高脂血症病史(红色表示)。黑色实线为在整个年龄阶段中通过多变量调整的HRRR值,阴影部分为95% CI

    Figure  1.  The association of various healthy lifestyles with the risk of stroke in different age groups

    Cox proportional risk regression and Poisson regression were used to assess the HR and RR for stroke by different healthy lifestyles in each age group (young: Y, middle: M, and old: O), respectively. Model 1 adjusts for age and sex (indicated in green). Model 2 adjusts for age, sex, years of education, marital status, family history of stroke, and whether there is a history of hypertension, diabetes or hyperlipidemia (indicated in red). The solid black line is the HR or RR adjusted by multivariate adjustment throughout the age range, and the shaded area is the 95% CI.

    表  1  基线研究对象中有无发生脑卒中的人口学基本特征

    Table  1.   Characteristics of study participants according to stroke at baseline

    特征Feature 总人群 Total (n=31 771) 发生脑卒中 Stroke (n=488) 未发生脑卒中 Non-stroke (n=31 283) P值value
    年龄/岁Age/years 55.48±11.28 62.92±7.64 55.36±11.29 < 0.001
    女性Female 18 882(59.43) 203(41.59) 18 679(59.71) < 0.001
    受教育年限/年Years of education/years < 0.001
      ≤6 14 221(44.76) 307(62.91) 13 914(44.48)
      7~<12 15 310(48.19) 174(35.66) 15 136(48.38)
      ≥12 2 240(7.05) 7(1.43) 2 233(7.14)
    未婚Unmarried 2 199(6.92) 35(7.17) 2 164(6.92) 0.897
    健康生活方式Healthy lifestyle
      不吸烟Non-smoking 25 259(79.50) 326(66.80) 24 933(79.70) < 0.001
      积极体育锻炼Active physical activity 7 795(24.53) 119(24.39) 7 676(24.54) 0.980
      均衡膳食Balanced diet 27 013(85.02) 371(76.02) 26 642(85.16) < 0.001
      正常体重Normal body weight 14 377(45.25) 177(36.27) 14 200(45.39) < 0.001
    健康生活方式评分/分Healthy lifestyle score/score < 0.001
      ≤1 4 854(15.28) 131(26.84) 4 723(15.10)
      2 12 641(39.79) 209(42.83) 12 432(39.74)
      ≥3 14 276(44.93) 148(30.33) 14 128(45.16)
    高血压Hypertention 16 051(50.52) 359(73.57) 15 692(50.16) < 0.001
    糖尿病Diabetes 4 281(13.47) 150(30.74) 4 131(13.21) < 0.001
    高脂血症Hyperlipidaemia 10 077(31.72) 203(41.60) 9 874(31.56) < 0.001
    脑卒中家族史Family history of stroke 2 182(6.87) 31(6.35) 2 151(6.88) 0.716
    注:①以人数(占比/%)或x±s表示。
    Note: ① Number of people(proportion/%) or x±s
    下载: 导出CSV

    表  2  每个年龄层的患病人数、暴露年数、脑卒中事件数量和粗脑卒中发生率的描述

    Table  2.   Description of the number of patients, years of exposure, number of stroke events, and crude stroke rates within each age stratum

    特征Feature 基线年龄分析/岁Analysis relative to age at baseline/years 暴露年龄分析/岁Analysis relative to age at exposure/years
    20~<62 62~<68 ≥68 20~<65 65~<70 ≥70
    总人群Total 20 837 6 679 4 255
    随访中位时间/年Median follow-up/years 5.1 4.6 4.6
    脑卒中Strokes
      人数Number of people 170 170 148
      占比/% Proportion/% (95% CI) 0.82 (0.71~0.95) 2.55 (2.20~2.96) 3.48 (2.97~4.07)
    随访人年Person-years of follow-up 120 757 52 147 27 424
    脑卒中事件数Stroke events 188 165 135
    脑卒中发病率/10万人年Incidence of stroke per 100 000 person-years (95% CI) 155.69 (134.95~179.61) 316.41 (271.64~368.57) 492.26 (415.85~582.72)
    注:每个人在每个年龄层内对风险年数的贡献被计算为参与者在不同年龄层内的潜在年龄。
    Notes: Each person′s contribution to years at risk within each age stratum was calculate as the participant potentially ages between age strata.
    下载: 导出CSV

    表  3  健康生活方式评分与脑卒中的风险比及相对风险

    Table  3.   Hazard ratio and relative risk for stroke by healthy lifestyle score

    年龄组Age group 健康生活方式评分Healthy lifestyle score HR值value (95% CI) 健康生活方式评分Healthy lifestyle score RR值value(95% CI)
    ≤1 2 ≥3 P趋势 Ptrend ≤1 2 ≥3 P趋势 Ptrend
    Y
      模型1 Model 1 1.00 0.70(0.47~1.03) 0.56(0.37~0.87) 0.011 1.00 0.73(0.51~1.06) 0.54(0.35~0.81) 0.003
      模型2 Model 2 1.00 0.74(0.50~1.08) 0.67(0.43~1.03) 0.080 1.00 0.77(0.54~1.12) 0.63(0.42~0.96) 0.033
    M
      模型1 Model 1 1.00 0.74(0.51~1.08) 0.57(0.37~0.87) 0.009 1.00 0.77(0.52~1.13) 0.59(0.39~0.91) 0.017
      模型2 Model 2 1.00 0.76(0.52~1.10) 0.59(0.39~0.91) 0.016 1.00 0.77(0.53~1.14) 0.61(0.40~0.94) 0.027
    O
      模型1 Model 1 1.00 0.74(0.50~1.11) 0.63(0.41~0.98) 0.047 1.00 0.67(0.44~1.03) 0.62(0.39~0.97) 0.046
      模型2 Model 2 1.00 0.76(0.51~1.14) 0.64(0.42~1.00) 0.050 1.00 0.69(0.45~1.05) 0.63(0.40~0.99) 0.050
    注:1. Cox比例风险回归和泊松回归分别评估了各年龄组(年轻组:Y,中年组:M,老年组:O)中的健康生活方式评分与脑卒中的HRRR值。
    2. 模型1调整了年龄和性别; 模型2调整年龄、性别、受教育年限、婚姻状况、脑卒中家族史、是否有高血压、糖尿病或高脂血症病史。
    Notes:1. Cox proportional risk regression and Poisson regression were used to assess the HR and RR for stroke by healthy lifestyles score in each age group (young: Y, middle: M, and old: O), respectively.
    2. Model 1 adjusts for age and sex. Model 2 adjusts for age, sex, years of education, marital status, family history of stroke, and whether there is a history of hypertension, diabetes or hyperlipidemia.
    下载: 导出CSV
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  • 收稿日期:  2023-06-07
  • 修回日期:  2023-09-26
  • 网络出版日期:  2024-02-05
  • 刊出日期:  2024-01-10

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