发热伴血小板减少综合征高发地区人群血清抗体流行状况及感染危险因素

龚磊; 陈晴晴; 汪金生; 徐鹏鹏; 程东林; 刘旭祥; 杨锟; 孙永; 储娜; 吴家兵

doi:10.16462/j.cnki.zhjbkz.2025.02.014

文章导航 > 中华疾病控制杂志 > 2025 > 29(2): 211-216

龚磊, 陈晴晴, 汪金生, 徐鹏鹏, 程东林, 刘旭祥, 杨锟, 孙永, 储娜, 吴家兵. 发热伴血小板减少综合征高发地区人群血清抗体流行状况及感染危险因素[J]. 中华疾病控制杂志, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

引用本文:

GONG Lei, CHEN Qingqing, WANG Jinsheng, XU Pengpeng, CHENG Donglin, LIU Xuxiang, YANG Kun, SUN Yong, CHU Na, WU Jiabing. Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

Citation:

GONG Lei, CHEN Qingqing, WANG Jinsheng, XU Pengpeng, CHENG Donglin, LIU Xuxiang, YANG Kun, SUN Yong, CHU Na, WU Jiabing. Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

引用本文:

Citation:

GONG Lei, CHEN Qingqing, WANG Jinsheng, XU Pengpeng, CHENG Donglin, LIU Xuxiang, YANG Kun, SUN Yong, CHU Na, WU Jiabing. Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

发热伴血小板减少综合征高发地区人群血清抗体流行状况及感染危险因素

doi: 10.16462/j.cnki.zhjbkz.2025.02.014

龚磊¹,
陈晴晴¹,
汪金生²,
徐鹏鹏³,
程东林⁴,
刘旭祥⁵,
杨锟⁶,
孙永¹,
储娜¹,
吴家兵^1, ,

1.
安徽省疾病预防控制中心, 合肥 230601
2.
安庆市疾病预防控制中心, 安庆 246005
3.
六安市疾病预防控制中心, 六安 237010
4.
滁州市疾病预防控制中心, 滁州 239099
5.
合肥市疾病预防控制中心, 合肥 230022
6.
马鞍山市疾病预防控制中心, 马鞍山 243011

基金项目:

安徽医科大学公共卫生学院协同育人创新项目 2024GWXTYRZ002

详细信息

通讯作者:
吴家兵, E-mail: wjb0386@163.com

中图分类号: R181.8
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- 文章访问数: 29
- HTML全文浏览量: 6
- PDF下载量: 7
- 被引次数: 0
出版历程
- 收稿日期: 2024-02-23
- 修回日期: 2024-11-20
- 网络出版日期: 2025-03-08
- 刊出日期: 2025-02-10

Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province

1.
Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China
2.
Anqing Municipal Center for Disease Control and Prevention, Anqing 246005, China
3.
Lu′an Municipal Center for Disease Control and Prevention, Lu′an 237010, China
4.
Chuzhou Municipal Center for Disease Control and Prevention, Chuzhou 239099, China
5.
Hefei Municipal Center for Disease Control and Prevention, Hefei 230022, China
6.
Maanshan Municipal Center for Disease Control and Prevention, Maanshan 243011, China

Funds:

Collaborative Education Innovation Project of School of Public Health, Anhui Medical University 2024GWXTYRZ002

More Information

Corresponding author: WU Jiabing, E-mail: wjb0386@163.com

摘要

摘要: 目的了解安徽省发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome, SFTS)高发地区自然人群血清免疫球蛋白G(immunoglobulin G, IgG)抗体的流行状况及感染的影响因素, 为SFTS防控工作提供依据。方法收集2021年SFTS高发地区自然人群血清样本及流行病学资料, 根据抗体检测结果分为IgG抗体阴性组和阳性组, 分析两组在一般人口资料、既往健康状况、环境暴露情况、媒介暴露情况的差异, 采用χ² /Z检验进行单因素分析, 针对两组资料在单因素分析基础上进行多因素logistic回归分析。结果本研究共纳入安徽省SFTS高发地区自然人群1 255例, 其中IgG抗体阳性组174例(13.86%)。单因素分析结果显示, 两组人群在一般人口资料(村类别和年龄)方面的差异有统计学意义(均P < 0.05);在既往健康状况方面, 两组人群在曾经是否诊断为SFTS方面的差异均有统计学意义(χ² =13.678, P < 0.05);在环境暴露情况方面, 两组人群在从事农业生产、被蜱虫叮咬过、住宅周围环境有杂草生长、住宅周围见过蜱虫、经常野外工作等方面的差异均有统计学意义(均P < 0.05);在媒介暴露情况方面, 两组人群在是否在鼠洞附近坐卧上的差异有统计学意义(χ² =8.576, P < 0.05)。二元logistic回归分析结果显示在监测村(OR=2.093, 95% CI: 1.489~2.941)、高年龄(OR=1.028, 95% CI: 1.013~1.043)、曾诊断为SFTS(OR=3.089, 95% CI: 1.021~9.346)、从事农业生产(OR=1.728, 95% CI: 1.090~2.741)、曾被蜱虫叮咬过(OR=1.990, 95% CI: 1.366~2.898)均是IgG抗体阳性的危险因素(均P < 0.05)。结论本研究发现安徽省高发地区自然人群中SFTS特异性IgG抗体阳性率较高, 应加强对高发地区人群的健康干预, 降低人群感染风险。
- 发热伴血小板减少综合征 /
- 抗体 /
- 新发传染病
Abstract: Objective The purpose of this study was to understand the level of IgG in serum of natural people in areas with high incidence of severe fever with thrombocytopenia syndrome (SFTS) in Anhui Province and its influencing factors, so as to provide basis for the prevention and control of SFTS. Methods The serum samples and epidemiological data of natural population in areas with high incidence of SFTS were collected in the year of 2021 and divided into immunoglobulin G (IgG) negative group and positive group according to the results of IgG antibody test, and compare the demographic characteristics, past health status, environmental and medium exposure between the two groups. χ² or Z test were used for univariate analysis, and logistic regression model was used for multivariate analysis. Results A total of 1 255 cases were included in this study, of which 174 cases (13.86%) were IgG antibody positive. The univariate analysis showed that there was a significant difference in the demographic characteristics of the two groups in terms of village type and age (all P < 0.05). There was a significant difference in the past health status of the two groups in terms of whether SFTS was diagnosed or not (χ² =13.678, P < 0.05). There was a significant difference in the environmental exposure of the two groups in terms of engaging in agricultural production, being bitten by ticks, living with weed and ticks around residential areas, and working in the field (P < 0.05). There was a significant difference in the medium exposure of the two groups in terms of sitting and lying near the rat hole (χ² =8.576, P < 0.05). The binary logistic regression analysis showed that the monitoring villages (OR=2.093, 95% CI: 1.489-2.941), high age (OR=1.028, 95% CI: 1.013-1.043), had been diagnosed with SFTS (OR=3.089, 95% CI: 1.021-9.346), engaged in agricultural production (OR=1.728, 95% CI: 1.090-2.741), and had been bitten by ticks (OR=1.990, 95% CI: 1.366-2.898) were the risk factors for IgG antibody positive (all P < 0.05). Conclusions This study finds that the IgG antibody positive rate is higher in natural populations in areas with high incidence of SFTS in Anhui province. Therefore, it is necessary to strengthen health interventions for populations in these areas to reduce the risk of infection.
- Severe fever with thrombocytopenia syndrome /
- Antibody /
- Emerging infectious disease

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表 1 SFTS高发地区自然人群体内IgG抗体阴性组与阳性组的一般资料比较

Table 1. Comparison of general data between IgG antibody negative group and positive group in natural population with high incidence areas of SFTS

变量	IgG抗体阴性组(n=1 081)^①	IgG抗体阳性组(n=174)^①	χ²/Z值	P值
年龄/岁	60.87±12.62	63.87±9.80	-2.616	0.010
村类别
有病例村	505(46.72)	112(64.37)	18.685	＜0.001
无病例村	576(43.28)	62(35.63)
性别
男	443(40.98)	65(37.36)	0.817	0.366
女	638(59.02)	109(62.64)
职业
农民	813(75.21)	145(83.33)	9.263	0.159
家务待业	88(8.05)	7(4.02)
采茶	54(5.00)	10(5.75)
工人	58(5.37)	5(2.87)
干部职员	28(2.59)	1(0.57)
其他	26(2.41)	4(2.30)
服务行业	15(1.39)	2(1.15)
文化程度
文盲	399(36.91)	77(44.25)	6.912	0.141
小学	358(33.12)	58(33.33)
初中	232(21.46)	32(18.39)
高中	53(4.90)	5(2.87)
大专及以上	39(3.61)	2(1.15)
注：SFTS, 发热伴血小板减少综合征; IgG, 免疫球蛋白G。 ①以x±s或人数(占比/%)表示。

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表 2 IgG抗体阴性组与阳性组的健康状况比较

Table 2. Comparison of health status between IgG antibody negative group and positive group

变量	IgG抗体阴性组(n=1 081)^①	IgG抗体阳性组(n=174)^①	χ²值	P值
是否诊断为SFTS
否	1 073(99.26)	167(95.98)	13.678	< 0.001
是	8(0.74)	7(4.02)
是否诊断为HFRS
否	1 079(99.81)	174(100.00)	0.322	0.570
是	2(0.19)	0(0.00)
是否有慢性疾病
否	663(61.33)	100(57.47)	0.937	0.333
是	418(38.67)	74(42.53)
注：IgG, 免疫球蛋白G; SFTS, 发热伴血小板减少综合征; HFRS, 肾综合征出血热。 ①以人数(占比/%)表示。

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表 3 IgG抗体阴性组与阳性组环境暴露情况比较

Table 3. Comparison of environmental exposure between IgG antibody negative group and positive group

变量	IgG抗体阴性组(n=1 081)^①	IgG抗体阳性组(n=174)^①	χ²值	P值
是否从事农业生产
否	271(25.07)	25(14.37)	9.524	0.002
是	810(74.93)	149(85.63)
是否被蜱虫叮咬过
否	889(82.24)	117(67.24)	21.196	< 0.001
是	192(17.76)	57(32.76)
住宅周围环境是否有杂草生长
否	502(46.44)	65(37.36)	4.991	0.025
是	579(53.56)	109(62.64)
住宅周围是否见过蜱虫
否	840(77.71)	110(63.22)	17.099	< 0.001
是	241(22.29)	64(36.78)
家中是否饲养宠物或家畜
否	538(49.77)	79(45.40)	1.143	0.285
是	543(50.23)	95(54.60)
是否和SFTS患者共同生活
否	1 071(99.07)	171(98.28)	0.934	0.334
是	10(0.93)	3(1.72)
是否经常捕猎野生动物
否	1 061(98.15)	173(99.43)	1.482	0.223
是	20(1.85)	1(0.57)
是否经常野外工作
否	737(68.18)	98(56.32)	9.461	0.002
是	344(31.82)	76(43.68)
注：IgG, 免疫球蛋白G; SFTS, 发热伴血小板减少综合征。 ①以人数(占比/%)表示。

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表 4 IgG抗体阴性组与阳性组媒介暴露情况比较

Table 4. Comparison of media exposure between IgG antibody negative group and positive group

变量	IgG抗体阴性组(n=1 081)^①	IgG抗体阳性组(n=174)^①	χ²值	P值
是否接触鼠类
否	789(72.99)	120(68.97)	1.214	0.270
是	292(27.01)	54(31.03)
是否食用过被老鼠排泄物污染的食物或水
否	1 069(98.89)	172(98.85)	0.002	0.963
是	12(1.11)	2(1.15)
是否在鼠洞附近坐卧
否	975(90.19)	144(82.76)	8.576	0.003
是	106(9.81)	30(17.24)
房内有无鼠或鼠排泄物
否	579(53.56)	83(47.70)	2.065	0.151
是	502(46.44)	91(52.30)
食物/粮食有无防鼠设备
否	734(67.90)	121(69.54)	0.186	0.667
是	347(32.10)	53(30.46)
工作场所有无鼠洞或鼠排泄物
否	868(80.30)	133(76.44)	1.383	0.240
是	213(19.70)	41(23.56)
注：IgG, 免疫球蛋白G; SFTS, 发热伴血小板减少综合征。 ①以人数(占比/%)表示。

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表 5 IgG抗体阳性多因素logistic回归分析结果

Table 5. Results of multivariate logistic regression analysis of IgG antibody positivity

变量	β值	s_x	Wald χ²值	P值	OR值(95% CI)
年龄/岁	0.027	0.008	13.040	< 0.001	1.028(1.013~1.043)
村类别
监测村	0.739	0.174	18.100	< 0.001	2.093(1.489~2.941)
对照村					1.000
是否诊断为SFTS
是	1.128	0.565	3.986	0.046	3.089(1.021~9.346)
否					1.000
是否从事农业生产
是	0.547	0.235	5.409	0.020	1.728(1.090~2.741)
否					1.000
是否被蜱虫叮咬过
是	0.688	0.192	12.854	< 0.001	1.990(1.366~2.898)
否					1.000
注：IgG, 免疫球蛋白G; SFTS, 发热伴血小板减少综合征。 ①表示参照组。

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