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CN 34-1304/R ISSN 1674-3679

2016 Vol. 20, No. 6

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Sexual features of heterosexual intercourse and HIV situation among men having sex with men in Kunming
WANG Yu-miao, ZHANG Ren-zhong, LI You-fang, WANG Jue, LI Zhi-qing, WANG Ling, PAN Song-feng, MA Yan-ling, JIA Man-hong, LU Lin
2016, 20(6): 539-542,547. doi: 10.16462/j.cnki.zhjbkz.2016.06.001
Abstract(314) PDF(38)
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Objective To understand sexual features of heterosexual intercourse among men having sex with men(MSM) and HIV infection status in Kunming, then to provide valid evidence for HIV intervention.Methods Non-probability sampling was carried on to recruit MSM as subject, an anonymous questionnaire survey and HIV /syphilis screening tests were conducted. Results Among 557 MSM surveyed, 16.3% had sex with female in the past six months, the average number of partners was 1.4,and multi-partnering(≥2 sexual partners)was reported as 20.9%, 32.0% had sex with female in the first time,using condoms in the last heterosexual accounted for 49.5%, while only 29.7% of MSM consistently used condom. The infection rates of HIV/syphilis were 9.9% and 6.6% respectively, others who had no heterosexual intercourse were:11.4% and 2.6% respectively, the infection rates of HIV/syphilis were not significantly different among them(all P>0.05). Multivariate Logistic regression analysis indicated that high school education and below, married,individual monthly income over 4 000 were more likely to have heterosexual behavior(all P<0.05). Conclusions MSM existed heterosexuality and condom utilization rate was lower, targeted measures should be taken, to strengthen the consciousness of condom use among MSM with heterosexual behavior, and the risk of HIV infected among female partners, reduce the risk of HIV/AIDS prevalence in ordinary women.
Analysis of high risk behaviors among left-behind women in high HIV epidemic rural areas
ZHANG Zu-yang, MA Yan-ling, LUO Hong-bing, SHI Yu-hua, SONG Li-jun, MEI Jing-yuan, LU Ji-yun, JIA Man-hong
2016, 20(6): 543-547. doi: 10.16462/j.cnki.zhjbkz.2016.06.002
Abstract(217) PDF(35)
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Objective To investigate the high risk behaviors and factors influencing human immunodeficiency virus (HIV) transmission among left-behind women (LBW) in rural areas with high HIV prevalence in China. Methods A cross-sectional investigation was conducted among 500 left-behind women from two high HIV prevalence areas in China during March to May, 2015. Probability proportion to size sampling (PPS) method was used for data analysis. Results The rate of AIDS awareness among LBW was 71.0%. A lower AIDS awareness rate were found in women aged over 35, at low education level, remarried and Han ethnic women, those from Lincang city or/and those didn't accept AIDS interventions. 28.6% of total LBW investigated had multi sex partner. Multi-factor logistic regression analysis showed age under 35, minority, widowhood, living in Lincang city, acception to AIDS interventions and spouse with drug addiction remain important factors in high risk of multi sexual behaviors. The rates of condom use of sex with a casual or commercial sex partner were 20.7% and 58.3% respectively. The rate of drug abuse among LBWs was 1.4%. The rate of acceptance to AIDS intervention was 67.4%. Conclusions Low rates of AIDS awareness, multi sexual partners and low rates of condom use were defined in LBW from high HIV prevalence areas in Yunnan province. HIV prevention interventions among LBW need to focus on minorities, women with low education levels, women without acceptance to AIDS interventions and women had multi-sex partners and drug addictions.
Evaluation on the data quality of HIV screening project in AIDS demonstration area of Henan Province
HUI Xiao-qing, YANG Yong-li, WANG Ying, MAO Sai-cai, JIA Xiao-can, WANG Lan-lan, ZHANG Meng, JIN Hui-ming, SHI Xue-zhong
2016, 20(6): 548-550,554. doi: 10.16462/j.cnki.zhjbkz.2016.06.003
Abstract(189) PDF(42)
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Objective To evaluate the representativeness of sample and the quality of the data obtained from human immunodeficiency virus (HIV) screening population of the AIDS demonstration area in Henan Province and estimate the positive rate of HIV and morbidity accurately. Methods A multi-stage random cluster sampling was performed and choosing about 2 million residents were recruited from 5 counties in Henan Province during September 2012 to June 2013. The questionnaire survey and physical examination were conducted among them. Sample representativeness, data integrity, data accuracy and entry timeliness were applied to evaluate the quality of data. Results The composition of the population was the same as the sixth census of the counties in 2010 (χ2=8.202,P=0.879). The integrity rate of the data was 82.356%. The rates of duplicate entry were 0.132% and 0.510% respectively based on personal information and physical examination information. The rate of logist error was less than 10%. The time interval from the physical examination to inputting was 0-386 days. Conclusions The representativeness of sample from the AIDS demonstration area in Henan Province is reliable, but the quality of data integrity, data accuracy and entry timeliness should be improved further.
Analysis on the effect of different HIV/AIDS diagnosis and treatment services models in two counties of Guizhou Province
LI Yan-yuan, ZHUO Yuan-ge, HE Kai-min, SHEN Li-mei, CHEN Qing-feng, WANG Lu, Han Meng-jie
2016, 20(6): 551-554. doi: 10.16462/j.cnki.zhjbkz.2016.06.004
Abstract(354) PDF(43)
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Objective To compare the effect of two different service models from HIV/AIDS diagnosis to Antiretroviral Therapy (ART) in two counties of Guizhou Province. Methods Information from the database system of D and P Counties was analyzed.County D performed the “one stop service” model from HIV/AIDS diagnosis to ART, while County P performed the standard model.The year when “one stop service” was performed and the year before were the observational years.The newly diagnosed HIV/AIDS adult residents reported by the two local counties were analyzed. The interval time from confirmation to ART, the proportion of CD4+T count testing(CD4 testing), the proportion of ART were used as the indexes for the effect comparison of the two counties. Results “One stop service”could sharply shorten the time from 55.00 days to 4.00 days. The proportion of CD4 testing of D County increased from 65.52% to 100.00%and the proportion of ART increased from 31.03% to 87.88%. The results were of statistical significance (all P<0.05). As a comparison, P County conducted the standard model during the two years. Its interval time from confirmation to ART changed from 68.00 days to 43.50 days. The proportion of CD4 testing changed from 90.91% to 88.24%. The proportion of ART varied from 45.45% to 58.82%.The results were of no statistical significance (all P>0.05). When compared to County P, D County's proportion of ART increased and the interval time was shortened. Conclusions “One stop service”simplified the streamline from diagnosis to ART. As a result it shortened the time from conformation to ART and reduced loss of HIV/AIDS cases.
Spatial distribution characteristics of global highly pathogenic avian influenza H5N1 based on the spatial point pattern analysis
SUN Li-qian, XIA Cong-cong, LI Rui, HU Yi, LIN Sui-heng, XIONG Cheng-long, ZHANG Zhi-jie
2016, 20(6): 555-558,563. doi: 10.16462/j.cnki.zhjbkz.2016.06.005
Abstract(278) PDF(34)
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Objective To explore the spatial distribution characteristics and identify high risk clusters, so as to provide scientific evidence for epidemic surveillance and trends of avian influenza H5N1. Methods H5N1 outbreak reported to World Organization for Animal Health (OIE) and the Food and Agriculture Organization (FAO) of the UN from January 2004 to December 2009 were collected. Spatial scan statistics and spatial clustering analysis were used to analyze the spatial distribution of HPAI H5N1. Results Spatial scan statistics showed that the epidemic distribution was non-random. 15 high risk clusters were detected, which were mainly concentrated in Central and Southern Europe, the Northeast of Africa, and the Southeast of Asia. Spatial clustering analysis showed that high risk clusters were mainly concentrated in Germany, France, Switzerland, Italy, and Southeast Asia region. Conclusions Clustering of H5N1 outbreaks was confirmed in this study, and high risk clusters were mainly concentrated in the Central and Southern Europe and the Southeast of Asia,where enhanced surveillance should be conducted. Birds migration may play a key role in H5N1 spreading across continents over a long distance.
Discovering candidate serum biomarker of smear-negative pulmonary tuberculosis by proteome quantitative analysis and verifying SHBG
ZHOU Ying, LI Cui-ping, HE Xiao, LI Hong-tao, ZANG Ning, ZHENG Yan-yan, HE Min
2016, 20(6): 559-563. doi: 10.16462/j.cnki.zhjbkz.2016.06.006
Abstract(243) PDF(39)
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Objective To discover and verify the serum differential expression proteins of smear-negative pulmonary tuberculosis by using a comparative proteomics approach. Methods Serum protein expression profiles from 30 cases of normal healthy controls, and 30 cases of smear-negative pulmonary tuberculosis patients were detected by iTRAQ labeling in combine with MALDI-TOF/MS,and analyzed by bioinformatics software. A proteins interaction diagram was drew,and SHBG was validated by ELISA. ROC was built by SPSS 20.0 software. Results Screened by iTRAQ labeling in combine with MALDI-TOF/MS,the confidential levels of 283 proteins were over 95%. Within 31 significantly differentially expressed proteins, the expression levels of 17 proteins were significantly increased, and 14 proteins were decreased in smear-negative pulmonary tuberculosis patients serum when compared to the normal healthy controls (P<0.05). After analysis on their functional interactions, 12 proteins such as SHBG appeared at the central position of the functional network. SHBG was found to be elevated in smear-negative pulmonary tuberculosis patients when compared to the normal controls and pneumonia patients as examined by ELISA (P<0.001), which was consistent with the iTRAQ result. Examining serum SHBG by ELISA achieved an area under the ROC of 0.92(P<0.001), the sensitivity was 87.14% and specificity was 85.11% in diagnosing smear-negative pulmonary tuberculosis. Conclusions These 12 proteins in the center of the functional network, screened by iTRAQ in combination with MALDI-TOF-MS might be the potential markers of smear-negative pulmonary tuberculosis. SHBG is suggested to be a possible serum candidate biomarker for pulmonary tuberculosis patients.
Factors associated with patients' delayed diagnosis of pulmonary tuberculosis in Haizhu District of Guangzhou City
WU Xiao-ying, ZHONG Xiao-yan, TAN Shou-yong, ZHANG Jin-xin, HUANG Jia-ling, SONG Jia-qi, DU Yu-hua, ZHANG Ya-hui, LUO Shao-xia
2016, 20(6): 564-567. doi: 10.16462/j.cnki.zhjbkz.2016.06.007
Abstract(357) PDF(40)
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Objective To analyze the factors associated with patients' delayed diagnosis of pulmonary tuberculosis in Haizhu District of Guangzhou City and provide scientific intervention measures to avoid the delay. Methods The random sampling method was adopted. There were 150 cases diagnosed with pulmonary tuberculosis from January 1st, 2014 to December 31st, 2014. They were investigated by face-to-face questionnaire, and the basic medical information was collected. Influential factors of delayed diagnosis of pulmonary tuberculosis were explored from common information, economic situation and clinical status. Results The patients' delay rate in 150 cases of pulmonary tuberculosis was 52.0% (78/150). Multi-factor analysis showed that the referral (OR=0.121, 95% CI: 0.028-0.513) and hemoptysis (OR=0.291, 95% CI: 0.098-0.860) were beneficial factors for the delay. The transportation expenses over 50 Chinese Yuan per month (OR=7.334, 95% CI: 1.729-31.113) and the symptom-driven (OR=3.225, 95% CI: 1.337-7.775) were risk factors leading to the delay. Conclusions Patients' delay diagnosis is popular in pulmonary tuberculosis patients in Haizhu District of Guangzhou, and we should spread public knowledge on pulmonary tuberculosis to reduce the occurrence and improve the convenience and accessibility of certificated tuberculosis medical institution, it is important to strengthen public consciousness of regular physical examination.
Association of red cell distribution width with serum lipids in Lianyungang rural population with hypertension
WANG Li-wei, YANG Wen-bin, YU Tao, WANG Wen, WANG Bin-yan, TANG Gen-fu, ZANG Tong-hua, QIN Xian-hui, WANG Yu, LI Jian-ping, HUO Yong, XU Xi-ping
2016, 20(6): 568-571,576. doi: 10.16462/j.cnki.zhjbkz.2016.06.008
Abstract(330) PDF(31)
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Objective To examine the relationship between red cell distribution width(RDW) and serum lipids in rural hypertensives in Lianyungang. Methods An epidemiological investigation was carried out, from May 2008 to July 2009, in residents aged 45 to 75 who were enrolled randomly in a rural area of Lianyungang. Standardized questionnaire investigation and physical examination were conducted to collect information on medical history, cardiovascular risk factors, etc. Red blood cell distribution width-coefficient of variation (RDW-CV), serum total cholesterol, triglyceride, high density lipoprotein cholesterol were measured using automatic clinical analyzers (Beckman Coulter), and low density lipoprotein cholesterol was calculated by Friedewald equation. Multiple linear regression model was performed to determine the relationship between red cell distribution width and serum lipids. Results In the study, 10 906 participants with hypertension were included in the final analysis. After adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, fasting blood-glucose, hemoglobin, mean corpuscular volume, smoking and drinking, RDW-CV was negatively associated with total cholesterol(β=-8.11, Sx=0.55,P<0.001), triglyceride(β=-3.73, Sx=0.79,P<0.001), high-density lipoprotein cholesterol(β=-0.96,Sx=0.17,P<0.001) and low density lipoprotein cholesterol (β=-6.41, Sx=0.50, P<0.001). In the further stratified analysis, a greater association between RDW-CV and high-density lipoprotein cholesterol(age≥60 versus <60, P for interaction<0.001)was observed in participants with higher age. Conclusions In conclusion, our results suggest that red cell distribution width was associated with total cholesterol, triglyceride, high-density lipoprotein cholesterol and low density lipoprotein cholesterol.
Prevalence and risk factors of high normal blood pressure among the people in western of Jilin Province
YANG Sen, YU Jian-xing, PANG Kai, YU Yang, PANG Hui, TAO Yu-chun, YU Ya-qin
2016, 20(6): 572-576. doi: 10.16462/j.cnki.zhjbkz.2016.06.009
Abstract(339) PDF(39)
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Objective To explore the prevalence and risk factors of high normal blood pressure among people in western of Jilin Province in 2012. Methods A multi-stage stratified cluster sampling method was used in this study, and a total of 4 009 people aged 18 to 79 years old were selected. Results The prevalences of normal blood pressure, high normal blood pressure, hypertension were 22.9%, 42.2%,and 34.9%,respectively. Compared with female, male had a higher prevalence of high normal blood pressure(χ2=48.564,P<0.001). One classification of high normal blood pressure wasⅠ(60.1%),Ⅱ(5.3%), and Ⅲ(34.6%),the other classification was A(65.8%), B(34.2%). Compared with normal blood pressure, dyslipidemia, diabetes, and overweight or obesity in high normal blood pressure was significantly different(all P<0.05). Multivariate Logistic regression analysis showed that age, gender, residence, drink, BMI, central obesity, and elevated TG were risk factors of high normal blood pressure(all P<0.05). Conclusions High normal blood pressure has high prevalence among people in western of Jilin Province. We should pay more attention to the lifestyle intervention.
A case-control study on influencing factors for the risk of systemic sclerosis among women
WANG Yu-jie, HUANG Xiao-lei, DUAN Yu, YANG Guo-jun, TAO Jin-hui, CHEN Shan-yu, XU Jian-hua, LI Xiang-pei, WU Guo-cui, WANG Jing, YE Dong-qing
2016, 20(6): 577-581. doi: 10.16462/j.cnki.zhjbkz.2016.06.010
Abstract(257) PDF(32)
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Objective To explore the impact of menstrual and obstetrical factors, daily lifestyle and environmental factors on systemic sclerosis (SSc) among women. Methods 100 female SSc patients from affiliated hospitals of Anhui Medical University and 400 female controls from communities of Hefei city were recruited from August 2012 to December 2015.Univariate and multiple Logistic regression analyses were used to examine the associations of environmental factorswith SSc risk. Results There were 11 factors associated with SSc when univariate unconditional Logistic regression was used. Multiple Logistic aggression analysis revealed that obesity (OR=0.464, 95% CI:0.229-0.939) was protective factor for SSc, and farmers (OR=4.458, 95% CI:2.379-8.352), teachers/accountant/clerk (OR=9.740, 95% CI:3.153-30.909), cobbler/textile worker/garment worker(OR=16.150, 95% CI:4.933-52.873), thinner (OR=3.733,95% CI:1.440-9.636), taking birth control pills (OR=3.994,95% CI:1.291-12.361), abortion (OR=4.679,95% CI:2.365-9.258), other contact people smoking (OR=5.059,95% CI:2.582-9.913), noise exposure (OR=2.184,95% CI: 1.018-4.685), organic solvents exposure (OR=4.432,95% CI:1.158-16.965) and history of drug allergy (OR=3.564,95% CI:1.425-8.916) were risk factors for SSc.Conclusions Many environmental factors were related to SSc. Preventive measures for SSc and rehabilitation measures for patients should be reinforced.
An epidemiological investigation on the prevalence of knee osteoarthritis in the middle-aged people in Heilongjiang Province
WANG Yi-dan, XING Bai-fen, RONG Jie-sheng, ZHU Lin, QIN Zheng-ji, TAO Yu-chun, LI Dan-na, JIANG Shan, ZHAO Ya-shuang, JIANG Li-ying
2016, 20(6): 582-585,594. doi: 10.16462/j.cnki.zhjbkz.2016.06.011
Abstract(178) PDF(39)
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Objective The study was conducted to investigate the prevalence of knee osteoarthritis in Harbin, Heilongjiang Province. Methods A cross-sectional study was performed among 416 community residents aged ≥40 with multi-stage sampling. All subjects were given a questionnaire and asked to undergo a physical examination. Results The prevalence of knee osteoarthritis was 7.23% for men and 10.09% for women, respectively. The prevalence of knee osteoarthritis increased with aging among women people(χ2=8.12,P=0.012). The body mass index (BMI) of osteoarthritis patients was significantly higher than that of non-osteoarthritis (t=1.07,P=0.038). Positive association between age and radiological disease severity was approved by Kendall correlation analysis(r=0.19,P=0.037). Jogging might be one of those protective factors(OR=0.67,95% CI:0.33-0.79). Conclusions The prevalence of knee osteoarthritis in 2013 decreased as compared to that in 2005. The prevalence in female was higher than that in male. Proper and moderate physical activities may be crucial in the prevention of knee osteoarthritis development.
Treat-to-target of rheumatoid arthritis and potential determinants
HUANG Ling-ling, XU Jian-hua, XU Sheng-qian, XIAO Hui, CHANG Ling, LIU Na, MA Qin
2016, 20(6): 586-589. doi: 10.16462/j.cnki.zhjbkz.2016.06.012
Abstract(354) PDF(31)
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Objective To investigate treat-to-target rate of rheumatoid arthritis (RA), analyse its potential determinants and to improve treat-to-target rate of RA. Methods 300 RA patients were recruited and clinical data were recorded detailedly. All 300 RA patients were devided into treat-to-target and not treat-to-target according to the disease activity score in 28 joints (DAS28). Results The treat-to-target rates of this study were 36.7%;RA patients who were treated-to-target had younger age, higher education, fewer swollen joint counts,fewer tender joint counts, lower visual analogue scale, lower patient global assessment, lower physician global assessment (PGA), lower rheumatoid factor, lower erythrocyte sedimentation rate, lower C-reactive protein level, lower joint function classification, lower health assessment questionnaire score and more regular treatment with disease-modifying anti-rheumatic drugs (≥3 months) when compared with those were not. Logistic regression analysis revealed that low PGA, low joint function classification and low C-reactive protein were independent determinants of treat-to-target. Conclusions The treat-to-target rate of RA patients was still low. Regular treatment with DMARDs was important to treat-to-target in RA. Low PGA, low C-reactive protein and low joint function classification were significant independent determinants for RA treat-to-target.
Causes and effects of pathology discrepancy in head and neck cancer patients-based on clinical evaluation
LI Ze-qing, WU Xiu-wei, WANG Nian-fei, SONG Geng, LI Chang-zhen, CHEN Wen-jun, WU Qiang, LI Fan-fan, CHEN Zhen-dong
2016, 20(6): 590-594. doi: 10.16462/j.cnki.zhjbkz.2016.06.013
Abstract(262) PDF(27)
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Objective To study the incidence, causes and effects of pathology discrepancy in head and neck cancer patients. Methods From August 2014 to April 2015 in the Second Affiliated Hospital of Anhui Medical University, 118 hospitalized patients with head and neck cancers were included in this study. The accuracy and absence of pathological diagnosis, discrepancy between clinical and pathological diagnosis and the prognosis of all the patients were assessed. The effects of discrepancy between pathological diagnosis and clinical diagnosis were categorized as follows: no harm, near miss, minimal harm, moderate harm and major harm. Results Among the 118 cases studied, there were 16 discrepancy between pathological diagnosis and clinical diagnosis. The causes of them include the underperforming pathologic sampling quality in 7 cases, complex pathological characteristics in 8 cases, experience of pathologist in 1 cases. Pathology error result in no harm was noted in 1 cases (6.3%). Near miss was observed in 3 cases (18.8%). Minimal harm was observed in 1 cases (6.3%), moderate harm was found in 11 cases (68.8%) while major harm was not modified. Conclusions The major reason of discrepancy between pathological diagnosis and clinical diagnosis are sampling and lesions complex (especially lymph node metastasis from unknown primary tumors and thyroid tumor). The large majority of diagnostic errors do not result in severe harm, and it depends on the experience of clinician.
Study on hypothyroidism caused by treating metastatic clear cell renal cell carcinoma with small molecule VEGFR-TKI
DING Xiao-ying, WU Jian-qiu, ZHANG Xiao-mei, TANG Wei-Yan, FENG Ji-feng, KOU Ying-ying, TANG Yi-qun
2016, 20(6): 595-599. doi: 10.16462/j.cnki.zhjbkz.2016.06.014
Abstract(215) PDF(29)
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Objective To investigate the incidence of hypothyroidism and efficacy of metastatic clear cell renal cell carcinoma treated with small molecule VEGFR-TKI. Methods A retrospective study was conducted to analyze the clinical data of 24 patients treated with TKI (Axitinib or Sorafenib) therapy(n=10) or cytokine therapy(n=14) from November 2009 to December 2010. The change trend of thyroid function index and prognosis between TKI group and control group were analyzed. Results TKI group with hypothyroidism was higher than control group(50.0% vs. 7.1%, χ2=5.714, P=0.017). The median time of hypothyroidism was 56.2 months, thyroid stimulating hormone (TSH) increased obviously, free thyroxine (FT4) decreased synchronously and free triiodothyronine (FT3) fall time was relatively lagging behind in TKI group. The median overall survival was 21(95% CI:0.001-54.200) months of TKI group versus 15(95% CI:4.000-26.000) months of control group (P=0.265). Conclusions The incidence of hypothyroidism of TKI group is significantly higher than the control group, the survival time is longer. The hypothyroidism is a common side effect of metastatic clear cell renal carcinoma patients receiving small molecule VEGFR-TKI. Long term monitoring thyroid function and timely intervention of hypothyroidism can improve the patient's treatment compliance and quality of life.
Application of fast-track pathway in perioperative patients with primary hepatic carcinoma
REN Chun-xia, LI Lun-lan, DING Ping, WANG Li, WANG Hong-xia, WU Le, FAN Yin-guang
2016, 20(6): 600-603,608. doi: 10.16462/j.cnki.zhjbkz.2016.06.015
Abstract(260) PDF(46)
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Objective To evaluate the effect of clinical nursing pathway based on fast-track surgery in perioperative patients with primary hepatic carcinoma (PHC). Methods A total of 87 PHC patients undergoing elective hepatectomy were enrolled, and divided into two groups by admission time, namely the control group (45 cases) and the experimental group (42 cases). The patients in the experimental group participated in clinical nursing pathway (CNP) based on the fast-track surgery while the cases in the control group received traditional perioperative nursing care of hepatectomy. Level of perioperative anxiety and postoperative pain, discomfort and complications, hospital stay, costs and re-admission rate were measured. Results Final analysis included 39 patients in the experimental group and 43 patients in the control group. Compared with the control group, scores of self-rating anxiety scales (SAS) and pain were significantly lower in the experimental group (all P<0.05). No significantly differences between the two groups were observed regarding postoperative discomfort and most of complications,hospitalization expense and re-admission rates (all P>0.05) while pulmonary infection rate was lower and hospital stay was shorter in the experimental group (all P<0.05). Conclusions Application of fast-track nursing pathway in perioperative patients with PHC can reduce operative stress and anxiety, achieve faster recovery,which is safe and effective.
Knowledge mapping analysis of the relationship between obesity and cancer
CHEN Yan-zi, LIU Li, FU Xiao-li, QI Min-jie, ZHAN Fang-fang, PING Zhi-guang
2016, 20(6): 604-608. doi: 10.16462/j.cnki.zhjbkz.2016.06.016
Abstract(232) PDF(36)
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Objective Obesity has become an important risk factor for cancer, the technology of analysis of knowledge mapping was used to explore the research hot spots and basic knowledge in this field, so as to provide reference for scientific research and policy formulation. Methods Visualizing technology-CiteSpace Ⅲ was used to analyze and show the result of 33296 articles which were extracted from Web of Science and Medline, The retrieve terms were (obesity OR obese OR fat OR overweight) AND (cancer OR tumour OR tumor OR carcinoma OR neoplasm). The time interval ranged from 2006 to 2015. Results According to the analysis of knowledge mapping,we observed the research hot spots and the source of basic knowledge clearly in recent 10 years,the research hot spots were the high frequencykeywords, the source of basic knowledge were high frequency co-citation references. Conclusions The cancers related to obesity are mainly breast cancer, colorectal cancer, hepatocellular carcionma, prostate-cancer, colon-cancer, endometrial cancer, etc.
Bioinformatics analysis and prediction of hsa-miR-32 target genes
PENG Can-can, MA Wen-li, XIA Wei, HUANG Zheng-liang, ZHENG Wen-ling
2016, 20(6): 609-613. doi: 10.16462/j.cnki.zhjbkz.2016.06.017
Abstract(231) PDF(38)
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Objective Bioinformatics software and database were applied to predict and analyze target genes and functions of hsa-miR-32, in order to provide a basis for the study of the mechanism of hsa-miR-32 and its target genes in cancer. Methods The sequence of miR-32 was got from miRBase database. The microarray data of disease were downloaded from the Gene Expression Omnibus(GEO) and the expression level of hsa-miR-32 in disease was analysed by miRGator and Qlucore Omics Explorer. PicTar, DIANA-microT-CDS, PITA and miRanda algorithm were used to predict target genes of hsa-miR-32. Combined with validated target genes, the gene set was analyzed by gene ontology(GO) and pathway enrichment. Results miR-32 was highly conserved among different species. Different expression levels of hsa-miR-32 were observed in different cancer tissues compared with adjacent normal tissues(all P<0.05). Gene ontology analysis indicated that 168 target genes were mainly enriched in positive regulation of gene expression, negative regulation of cell proliferation, negative regulation of signal transduction, cell death and other biology processes(all P<0.05). KEGG pathway analysis showed that these genes were mostly involved in small cell lung cancer, prostate cancer, glioma, melanoma, pathways in cancer, p53 signaling pathway and cell cycle(all P<0.05). Conclusions The target genes of hsa-miR-32 may have extensive functions and be closely related with cancer.
Analysis on absenteeism among primary students in rural area based on network report system
ZHOU Chang-ming, ZHAO Qi, SONG Xiao-xiao, XU Biao
2016, 20(6): 614-616,633. doi: 10.16462/j.cnki.zhjbkz.2016.06.018
Abstract(223) PDF(30)
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Objective To describe the occurrence of absenteeism of primary students in rural areas and analyze the distribution of absenteeism by time, people and place. Methods Web based absenteeism surveillance system supported by European Union project were established in two counties of Jiangxi Province, which covered 63 primary schools and 31 554 students. All absenteeism daily reports were collected from the system and analyzed by appropriate software. Results From 1st April, 2012 to 31st March, 2014, 18 407 absent records were reported and the absence rate was 0.16%. The major cause of absenteeism was illness (74.32%) and the absenteeism rate was 0.12%. The absence rate of boy students was higher than girl students and declined with grade increasing. And the absence rate due to illness reached its peak in spring and fall, the major reasons for absence were fever and cold which accounted for 64.25%. Conclusions The absenteeism surveillance system should be enhanced especially during the reversal of seasons and epidemic of diseases. The health education should be strengthened to improve school hygiene recognition of their parents and teachers.
An analysis of serum levels of BDNF and relative factors in the accident tendentiousness of drivers
YANG Jia-li, ZENG Xi, WANG Xiao-min, HUANG Kai-yong, NIE Guang-hui, YANG Li, DENG Yu, YANG Jun
2016, 20(6): 617-620. doi: 10.16462/j.cnki.zhjbkz.2016.06.019
Abstract(172) PDF(25)
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Objective To explore the related factors of the accident tendentiousness drivers, and to investigate the relationship between the serum levels of brain-derived neurotrophic factor (BDNF) and the accident tendentiousness drivers. Methods A case-control study, including 50 patients and 50 controls, were inquired the general condition and the living habits by questionnaire, and serum BDNF levels were assayed by enzyme linked immunosorbent assay (ELISA). Results Serum BDNF was significantly higher (t=-2.564,P=0.012) in patients [(3.18±2.19)ng/ml] compared with the controls [(2.23±1.43)ng/ml]. Serum BDNF levels of the drivers with driving experience <10 years in exposure group was significantly higher(t=-2.141,P=0.038) than those in control group. Serum BDNF levels of the drivers with primary school and junior middle school education in exposure group was significantly higher(t=-2.562,P=0.018) than those in control group. Serum BDNF levels of the drivers with ethnic minorities in exposure group was significantly higher(t=-3.047,P=0.004) compared with the control group. Non-conditional logistic regression analyses showed that the relative factors of the accident proneness were birth place and exercise frequency(all P<0.05). Conclusions Our results suggest that the driver accident tendentiousness are associated with serum BDNF levels, and birth place and exercise frequency may be protective factors of the accident proneness.
Application of cognitive interview in the development of health literacy scale for occupational population
WEI Min-qi, ZHOU Re-na, GU Wei-dong, ZHU Hong-yan, WANG Jian, FU Hua
2016, 20(6): 621-624. doi: 10.16462/j.cnki.zhjbkz.2016.06.020
Abstract(435) PDF(36)
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Objective To explore the application of cognitive interview technique in the development of health literacy scale among occupational population. Methods The preliminary scale was developed by collecting the evaluation indicators of health literacy through focus group interview among occupational population, and combining the questions from related scales in China and abroad. Then, the scale was finalized by conducting the cognitive interview to find the deviations between investigators and participants as well as optimizing the question structure, formulation and words usage. Results Two cognitive interviews were conducted. One interview was carried out to explore the related concept of occupational health literacy among 12 workers from occupational health field, and the other was to focus on the scale items among 26 workers from different fields. Through analyzing the cognitive process of participants, the preliminary scale was found some problems on the question formulation, words usage and option settings. Then the scale was revised and improved. Conclusions The cognitive interview is a method to verify the quality of scale, which could help the researchers to find the problems and defects of the scale when respondents answered the questions. and then improve the reliability and validity of the scale.
Application of multilevel models in analyzing on province-level social determinants of obesity in China
HE Liu, WU Jing, WANG Li-min, LI Yi-chong, ZHANG Mei, LIANG Xiao-feng
2016, 20(6): 625-629. doi: 10.16462/j.cnki.zhjbkz.2016.06.021
Abstract(209) PDF(23)
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Objective To explore province-level social determinants of obesity in Chinese population, using multilevel analysis. Methods Information of individual outcomes and individual-level variables was acquired from data of Chronic Disease Risk Factor Surveillance in China, 2007, while province-level factors were extracted from 7 social indicators, which were obtained from data of National Bureau of Statistics, using factor analysis method. Then, multilevel models were built to calculate the correlations of province-level factors with body mass index (BMI), obesity and central obesity. Results Among the nationwide population aged 18-69 years in 2007, mean BMI level was (23.27±3.37) kg/m2, rate of obesity and central obesity was 8.49% and 30.92%, respectively. Two province-level factors were extracted from 7 social indicators, and factor 2, which represented the provincial social and economic comprehensive development level, was found positively correlated with BMI (OR=1.09, 95% CI:1.04-1.10), obesity (OR=1.17, 95% CI:1.07-1.28) and central obesity (OR=1.19, 95% CI:1.10-1.30), while factor 1, which represented the provincial level of residents' consumption and health service, wasn't found statistically correlated with these three outcomes(all P>0.05). Conclusions In China, higher provincial social-economic comprehensive development level might be a risk factor for individual obesity, especially central obesity, which indicated that limited resources for obesity prevention and control may need to be allocated to provinces or regions with higher economic development level. In conclusion, in order to provide more evidence on improving the efficiency of non-communicable diseases (NCDs) prevention and control and help the Chinese policy makers to allocate health resources more reasonably, multilevel models could be used to perform researches on area-level social-economic influencers of NCDs.
The application of random forest for high dimensional DNA methylation data
ZHANG Qiu-yi, ZHAO Yang, WEI Yong-yue, ZHANG Ru-yang, CHEN Feng
2016, 20(6): 630-633. doi: 10.16462/j.cnki.zhjbkz.2016.06.022
Abstract(315) PDF(39)
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Objective To study the application of random forest algorithm for the high dimensional case-control DNA methylation data of rheumatoid arthritis(RA). Methods The RA dataset was obtained from gene expression omnbius (GEO) data repository (accession number GSE42861), which contained 689 samples (354 patients and 335 controls). A total of 2 433 cytosine-phosphate-guanine pairs of nucleotides(CpGs) sites on chromosome 9 were included because the identified RA associated area was located in this chromosome. First, these variables were sorted by the importance sores, by which were calculated through random forest. Second, stepwise random forest was carried out to find the subset variables which were most possibly associated with the outcome variable. Third, we conducted stepwise Logistic regression in the subset variables. Results Eighty important CpG sites were picked out by random forest. In our Logistic model, there were 13 statistically significant CpGs. The accuracy of the model contain these 13 CpGs was 88.29%. Conclusions Random forest algorithm can dramatically reduce the redundant variables and is applicable for high dimensional DNA methylation data.
The correlation between CASZ1、ZNF652、MTHFR、ATP2B1 and ALDH2 gene single nucleotide polymorphism and essential hypertension in Miao ethnic minority of Guizhou
ZHANG Zhu-ye, YU Yang-wen, LI Ling, LIU Tao, TANG Li-na
2016, 20(6): 634-636. doi: 10.16462/j.cnki.zhjbkz.2016.06.023
Abstract(213) PDF(33)
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Analysis of gout cognition status and misunderstanding in general population
TANG Jiang-ping, TAO Jin-hui, KUAI Yue, NIU Yang-yang, ZHANG Jing, GUO Zi-ming, ZHU Ruo-hui
2016, 20(6): 637-639. doi: 10.16462/j.cnki.zhjbkz.2016.06.024
Abstract(331) PDF(27)
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Association between diet habits and frailty of the elderly in rural area
QIAO Dan, WEI Fang, SHI Yu, WU Xue-shan, ZUO Qun
2016, 20(6): 640-641,646. doi: 10.16462/j.cnki.zhjbkz.2016.06.025
Abstract(232) PDF(23)
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Analysis of health services utilization change of married women in rural Guizhou Province from 2003 to 2013
CHEN Ying, SONG Shen-chao
2016, 20(6): 642-644. doi: 10.16462/j.cnki.zhjbkz.2016.06.026
Abstract(132) PDF(20)
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2016, 20(6): 645-646. doi: 10.16462/j.cnki.zhjbkz.2016.06.027
Abstract(128) PDF(17)
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