Association of HLA-DPA1/B1 gene polymorphisms with the susceptibility and outcomes of hepatitis C virus infection

P
EI Jia-ping; JI Xiao-wei; JIANG Long-feng; DENG Xiao-zhao; XU Xiao-dong; XIAO Wen; DING Wei-liang; ZHANG Jin-hai; WANG Chang-jun; ZHU Dan-yan; LI Bing-jun

doi:10.16462/j.cnki.zhjbkz.2016.02.002

Volume 20 Issue 2

Feb. 2016

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2016 > 20(2): 112-115,120

PEI Jia-ping, JI Xiao-wei, JIANG Long-feng, DENG Xiao-zhao, XU Xiao-dong, XIAO Wen, DING Wei-liang, ZHANG Jin-hai, WANG Chang-jun, ZHU Dan-yan, LI Bing-jun. Association of HLA-DPA1/B1 gene polymorphisms with the susceptibility and outcomes of hepatitis C virus infection[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 112-115,120. doi: 10.16462/j.cnki.zhjbkz.2016.02.002

Citation:

P EI Jia-ping, JI Xiao-wei, JIANG Long-feng, DENG Xiao-zhao, XU Xiao-dong, XIAO Wen, DING Wei-liang, ZHANG Jin-hai, WANG Chang-jun, ZHU Dan-yan, LI Bing-jun. Association of HLA-DPA1/B1 gene polymorphisms with the susceptibility and outcomes of hepatitis C virus infection[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 112-115,120. doi: 10.16462/j.cnki.zhjbkz.2016.02.002

Citation:

P EI Jia-ping, JI Xiao-wei, JIANG Long-feng, DENG Xiao-zhao, XU Xiao-dong, XIAO Wen, DING Wei-liang, ZHANG Jin-hai, WANG Chang-jun, ZHU Dan-yan, LI Bing-jun. Association of HLA-DPA1/B1 gene polymorphisms with the susceptibility and outcomes of hepatitis C virus infection[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 112-115,120. doi: 10.16462/j.cnki.zhjbkz.2016.02.002

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Association of HLA-DPA1/B1 gene polymorphisms with the susceptibility and outcomes of hepatitis C virus infection

doi: 10.16462/j.cnki.zhjbkz.2016.02.002

1. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China;
2. Department of Infection, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;
3. Institute of Disease Control and Prevention, Center for Disease Control and Prevention of Nanjing Command, Nanjing 210002, China;
4. Department of Microbiology and Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;
5. Department of Clinical Laboratory, Yixing People's Hospital, Yixing 214200, China

Received Date: 2015-11-08
Rev Recd Date: 2015-12-17

Abstract

Abstract

Objective To explore the relationships between human leukocyte antigen (HLA)-DP A1/B1 gene polymorphisms with the susceptibility and the outcomes of hepatitis C virus (HCV) infection among high-risk population in Jiangsu province. Methods HLA-DPA1/B1 gene alleles were detected in 748 subjects including 170 spontaneous clearance of HCV infection, 258 persistent HCV infections and 320 healthy controls by PCR-SBT，and the HLA alleles frequencies were compared between groups. Results The frequencies of HLA-DPA1*0103 and HLA-DPB1*0201 alleles were higher in HCV infection group than those in healthy control (40.7% vs 32.2%, P=0.003) (22.0% vs 12.5%, P<0.001). The frequencies of HLA-DPA1*0201 and HLA-DPB1*1401 alleles were lower in persistent HCV infection group than those in spontaneous clearance HCV infection group (7.9% vs 13.8%, P=0.018) (0.0% vs 2.1%, P=0.015). However, the data analyses showed that the frequencies of haplotype DPB1*0501-DPA1*0103 and DPB1*0201-DPA1*0103 were higher in HCV infection group than those in healthy control (P<0.001), but the frequencies of haplotype DPB1*0202-DPA1*0202 were lower than those in healthy control (P<0.001). Furthermore, the frequencies of haplotype DPB1*0202-DPA1*0202 were higher in persistent HCV infection group than those in spontaneous clearance HCV infection (P=0.004), while the frequencies of haplotype DPB1*0402-DPA1*0103 were lower in persistent HCV infection group than those in spontaneous clearance HCV infection (P=0.008). Conclusions HLA-DPA1/B1 alleles might be associated with the susceptibility and the outcomes of HCV infection among population at high risk in Jiangsu Province.
- Hepacivirus,
- HLA antigens,
- Gene frequency

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References(20)

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