Analysis of the impact of the diseases during the pregnancy on birth defects with random effects Logistic model

Objective To analyze the impact of the diseases during the early pregnancy of mother on the prevalence of birth defects,so as to provide evidence for making preventive measures through surveying birth defects in counties (cities)of Shanxi Province. Methods All the new mother and first degree relatives in six counties of Shanxi Province,during 2006 to 2008, were recruited. The random effects Logistic model was used to analyze the heterogeneity between six counties(cities),then the impact of the risk of early pregnancy disease on birth defects was explored, such as fever,colds,threatened abortion,genital tract infection and vomiting of pregnancy. Results The results of random effects Logistic model suggested that different regions had heterogeneity between groups,considering the difference, suffering from fever during early pregnancy, colds, threatened abortion were closely related to birth defects; the mother suffering from fever during early pregnancy(OR=1.855), colds(OR=1.924), threatened abortion(OR=3.361) increased the risk of birth defects. Conclusions The incidence of birth defects is closely related to the prevalence during pregnancy. We should increase the degree of attention to the pregnant women, and take effective prevention and early intervention measures to improve reproductive quality.