Analysis of urban community health elderly urine AD7c-NTP content

LIAO Jun; MA Jun; HUANG He-lang; YAN Ji; ZHOU Yue-ping; WU Lei

doi:10.16462/j.cnki.zhjbkz.2016.02.015

Volume 20 Issue 2

Feb. 2016

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2016 > 20(2): 165-167

LIAO Jun, MA Jun, HUANG He-lang, YAN Ji, ZHOU Yue-ping, WU Lei. Analysis of urban community health elderly urine AD7c-NTP content[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 165-167. doi: 10.16462/j.cnki.zhjbkz.2016.02.015

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LIAO Jun, MA Jun, HUANG He-lang, YAN Ji, ZHOU Yue-ping, WU Lei. Analysis of urban community health elderly urine AD7c-NTP content[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 165-167. doi: 10.16462/j.cnki.zhjbkz.2016.02.015

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Analysis of urban community health elderly urine AD7c-NTP content

doi: 10.16462/j.cnki.zhjbkz.2016.02.015

Epidemiology Teaching and Research Section, School of Public Health, Nanchang University, Nanchang 330006, China

Received Date: 2015-10-15
Rev Recd Date: 2015-12-03

Abstract

Abstract

Objective To measure the content of neuronal thread protein in the urine (AD7c-NTP) of urban community elderly who are over 60 years, and to explore the value in the early screening and diagnosis of Alzheimer's disease (AD). Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the contents of urine AD7c-NTP between the case group (86 cases) and age-matched control group (172 cases), then ROC curve was drawn and sensitivity and specificity were calculated. Results The average levels of AD7c-NTP in case group were (2.32±1.38) ng/ml, and in the control group were (0.86±0.62) ng/ml. The difference between the two groups was statistically significant(t=9.383,P<0.001); The area under the ROC curve was 0.854. When the threshold was selected as 1.313 ng/ml, the sensitivity was 84.9%, and specificity was 70.3%. Conclusions The levels of AD7c-NTP in the urine can be used as biological indicators of early screening and diagnosis of AD.
- Aged,
- Alzheimer disease,
- ROC curve

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References(18)

References

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