Prediction of has-miR-16 target genes and its bioinformatics analysis

LI Wu; HE Qing-zhi; SUN Shi-bo; PAN Xiao-yuan; ZENG Huai-cai

doi:10.16462/j.cnki.zhjbkz.2016.02.022

Volume 20 Issue 2

Feb. 2016

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2016 > 20(2): 193-197

LI Wu, HE Qing-zhi, SUN Shi-bo, PAN Xiao-yuan, ZENG Huai-cai. Prediction of has-miR-16 target genes and its bioinformatics analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 193-197. doi: 10.16462/j.cnki.zhjbkz.2016.02.022

Citation:

LI Wu, HE Qing-zhi, SUN Shi-bo, PAN Xiao-yuan, ZENG Huai-cai. Prediction of has-miR-16 target genes and its bioinformatics analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(2): 193-197. doi: 10.16462/j.cnki.zhjbkz.2016.02.022

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Prediction of has-miR-16 target genes and its bioinformatics analysis

doi: 10.16462/j.cnki.zhjbkz.2016.02.022

1. Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China;
2. Department of Biology, School of Pharmaceutical and Biological Sciences, University of South China, Hengyang 421001, China

Received Date: 2015-10-18
Rev Recd Date: 2015-12-11

Abstract

Abstract

Objective The aim is to predict the target genes of has-miR-16 and to analyze the molecular function, biological process and signal pathway enrichment of target genes, and comprehensively know living activity process and disease associated with miR-16. Methods The collection of target genes were predicted with bioinformatics methods and relevant literature. Cytoscape 3.2.1 and the database for annnotation visualization and integrated discovery(DAVID) database were used to analyze the GO(gene ontology) annotation and KEGG(kyoto encyclopedia of genes and genomes) signal pathway enrichment respectively.Results The mature sequence of miR-16 among species had highly conservative property. The molecular functions of 397 target genes were significantly invovled in protein binding, DNA binding, enzyme activity, and insulin-like growth factor receptor activity, etc. Biological processes of these genes were significantly associated with the process of development, cell adhesion, neurogenesis, cell metabolism and cell cycle regulation process. These target genes were also involved in cancer pathway, p53 signal pathway, neurotrophin signal pathway. Conclusions Has-miR-16 is involve in some human living activities and disease process through regulating target genes, especially cancer.
- Genes,
- Computational biology,
- Forecasting

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References(28)

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