Survival rate and risk factors of mortality among 358 adult HIV/AIDS patients receiving highly active antiretroviral therapy in Shijiazhuang

Objective To explore the survival status and risk factors among adult HIV/AIDS patients receiving highly active antiretroviral therapy (HAART) in Shijiazhuang. Methods This retrospective cohort study enrolled 358 HIV/AIDS patients receiving HAART in Shijiazhuang City from 2005 to 2013. Kaplan-Meier method was used to estimate the survival rate. Cox regression model was performed to analyze the risk factors associated with survival status. Trend F-H test was used to identify the ordinal tendency of different CD4⁺ T cell counts baseline. Results The overall mortality of 358 HIV/AIDS patients receiving HAART was 2.75/100 person-years. The 1, 3 and 5 year cumulative survival rate was 92%, 91% and 86%.The results of Cox analysis showed that baseline CD4⁺ T cell counts, clinical staging, hemoglobin and route of HIV infection are influencing factors of survival status. The trend F-H test showed that the higher baseline CD4⁺ T cell counts were associated with lower mortality risk. Conclusions The effect of HAART in Shijiazhuang is satisfactory. The early standard treatment helps to improve the survival status of HIV/AIDS patients.