Study on the effect of histone deacetylase gene polymorphism and environmental factors on type 2 diabetes mellitus

CHENG Qiu-ting; LIAO Ri-fang; YU Yong-ji; YANG Meng; ZHENG Ying-ying; CHEN Deng-zhou; MA Shu-li; CENG Zhuan-ping

doi:10.16462/j.cnki.zhjbkz.2020.04.004

Volume 24 Issue 4

Jun. 2020

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CHENG Qiu-ting, LIAO Ri-fang, YU Yong-ji, YANG Meng, ZHENG Ying-ying, CHEN Deng-zhou, MA Shu-li, CENG Zhuan-ping. Study on the effect of histone deacetylase gene polymorphism and environmental factors on type 2 diabetes mellitus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 389-393. doi: 10.16462/j.cnki.zhjbkz.2020.04.004

Citation:

CHENG Qiu-ting, LIAO Ri-fang, YU Yong-ji, YANG Meng, ZHENG Ying-ying, CHEN Deng-zhou, MA Shu-li, CENG Zhuan-ping. Study on the effect of histone deacetylase gene polymorphism and environmental factors on type 2 diabetes mellitus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 389-393. doi: 10.16462/j.cnki.zhjbkz.2020.04.004

Citation:

CHENG Qiu-ting, LIAO Ri-fang, YU Yong-ji, YANG Meng, ZHENG Ying-ying, CHEN Deng-zhou, MA Shu-li, CENG Zhuan-ping. Study on the effect of histone deacetylase gene polymorphism and environmental factors on type 2 diabetes mellitus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 389-393. doi: 10.16462/j.cnki.zhjbkz.2020.04.004

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Study on the effect of histone deacetylase gene polymorphism and environmental factors on type 2 diabetes mellitus

doi: 10.16462/j.cnki.zhjbkz.2020.04.004

1.
Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
2.
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3.
The Second People's Hospital of Huadu, Guangzhou 510850, China

Funds: Natural Science Fundation of Guangdong Province(2018A030313435, 2018A0303130249); Project of Administration of Traditional Chinese Medicine of Guangdong Province of China(20181060); Epidemiological Study of Glycolipid Metabolism in Guangdong Province(201701)

More Information

Corresponding author: CAI Li, E-mail:caili5@mail.sysu.edu.cn
Received Date: 2019-11-08
Rev Recd Date: 2020-02-11
Publish Date: 2020-04-10

Abstract

Abstract

Objective To examine whether polymorphisms of histone deacetylase(HDACs) and environment factors can be implicated in type 2 diabetes mellitus(T2 DM), and to provide evidence for the prevention and treatment of T2 DM. Methods In 2017, T2 DM patients and controls were selected from 17 villages in Huadu District, Guangzhou. According the Diagnostic criteria for T2 DM, the case group of T2 DM was matched with control group from the population diagnosed as normal by gender, age no more than 5 years old, and from the same natural village. Conditional logistic regression model was used to analyze the effect of gene and environment and their interaction on T2 DM. Results The average age of 499 cases group were(61.53±13.08) years old, and the average age of 499 controls group were(61.48±13.09) years old. There were no statistic difference between two groups. Furthermore, the two groups were gender-balanced too. In conditional logistic regression model, we found that glycerin trilaurate(TG) abnormalities(OR=2.410, 95% CI: 1.755-3.310, P < 0.001) and cholesterol total(TC) abnormalities(OR=1.436, 95% CI: 1.046-1.972, P=0.025) were risk factors for T2 DM. The subjects carries rs72792338 TC+TT genotype(OR=0.526, 95% CI: 0.349-0.793, P=0.002) had lower the risk to develop T2 DM. Conclusions Abnormal TG and TC are risk factors for T2 DM. Rs72792338 TT and TC genotype carryings decrease the risk of T2 DM.
- Type 2 diabetes mellitus,
- Histone deacetylase,
- Interaction

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References(11)

References

[1]	杨雪琛, 东梅, 王倩.组蛋白去乙酰化酶和糖尿病相关性研究进展[J].中国糖尿病杂志, 2015, 23(11): 1050-1052. DOI: 10.3969/j.iddn.1006-6187.2015.11.023. Yang XC, Dong M, Wang Q. Research progress of the correlation between histone deacetylases and diabetes mellitus[J]. Chin J Diabetes, 2015, 23(11): 1050-1052. DOI: 10.3969/j.iddn.1006-6187.2015.11.023.
[2]	曾转萍. HDAC、SIRT1基因多态性及环境因素与2型糖尿病关系的病例对照研究[D].广州: 南方医科大学, 2014. DOI: 10.7666/d.Y2617902. ZengZP.AssociationsbetweenpolymorphismsofHDAC, SIRT1andenvironmentalfactorsinpatientswithtype2diabetesmellitus[D].Guangzhou: SouthernMedicalUniversity, 2014. DOI: 10.7666/d.Y2617902.
[3]	中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志, 2018, 38(4): 292-344. DOI: 10.19538/j.nk2018040108. Chinese Diabetes Society. Guidelines for the prevention and control of type 2 diabetes in China(2017 Edition)[J]. Chin J of Practical Internal Med, 2018, 38(4): 292-344. DOI: 10.19538/j.nk2018040108.
[4]	王增武, 范国辉, 张林峰, 等.北方农村地区男性代谢综合征与饮酒关系研究[J].中华疾病控制杂志, 2015, 19(4): 348-351. DOI: 10.16462/j.cnki.zhjbkz.2015.04.008. Wang ZW, Fan GH, Zang LF, et al. Association study between metabolic syndrome and alcohol consumption among rural male residents in northern China[J]. Chin J Dis Control Prev, 2015, 19(4): 348-351. DOI: 10.16462/j.cnki.zhjbkz.2015.04.008.
[5]	Mihaylova MM, Vasquez DS, Ravnskjaer K, et al. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis[J]. Cell, 2011, 145(4): 607-621. DOI: 10.1016/j.cell.2011.03.043.
[6]	Jolma A, Yan J, Whitington T, et al. DNA-binding specificities of human transcription factors[J]. Cell, 2013, 152(1-2): 327-339. DOI: 10.1016/j.cell.2012.12.009.
[7]	Knutson SK, Chyla BJ, Amann JM, et al. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks[J]. EMBO J, 2008, 27(7): 1017-1028. DOI: 10.1038/emboj.2008.51.
[8]	Galmozzi A, Mitro N, Ferrari A, et al. Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue[J]. Diabetes, 2013, 62(3): 732-742. DOI: 10.2337/db12-0548.
[9]	Grimes JA, Nielsen SJ, Battaglioli E, et al. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex[J]. J Biol Chem, 2000, 275(13): 9461-9467. DOI: 10.1074/jbc.275.13.9461.
[10]	Zhang L, Curhan GC, Hu FB, et al. Association between passsive and active smoking and incident type 2 diabetes in women[J]. Diabetes Care, 2011, 34(4): 892-897. DOI: 10.2337/dc10-2087.
[11]	Tsai AC, Lee SH. Determinants of new-onset diabetes in older adults-Results of a national cohort study[J]. Clin Nutr, 2015, 34(5): 937-942. DOI: 10.1016/j.clnu.2014.09.021.