Association of leukocyte telomere length in peripheral blood and the risk of mild cognitive impairment in elderly subjects:a case-control study

YANG Tong; WANG Hua-lou; CHEN Chong; ZHAO Hui-chao; XIONG Ying; JIA Jing-ya; ZHANG Mei-lin; MA Fei

doi:10.16462/j.cnki.zhjbkz.2020.04.008

Volume 24 Issue 4

Jun. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(4): 409-412

YANG Tong, WANG Hua-lou, CHEN Chong, ZHAO Hui-chao, XIONG Ying, JIA Jing-ya, ZHANG Mei-lin, MA Fei. Association of leukocyte telomere length in peripheral blood and the risk of mild cognitive impairment in elderly subjects:a case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 409-412. doi: 10.16462/j.cnki.zhjbkz.2020.04.008

Citation:

YANG Tong, WANG Hua-lou, CHEN Chong, ZHAO Hui-chao, XIONG Ying, JIA Jing-ya, ZHANG Mei-lin, MA Fei. Association of leukocyte telomere length in peripheral blood and the risk of mild cognitive impairment in elderly subjects:a case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 409-412. doi: 10.16462/j.cnki.zhjbkz.2020.04.008

Citation:

YANG Tong, WANG Hua-lou, CHEN Chong, ZHAO Hui-chao, XIONG Ying, JIA Jing-ya, ZHANG Mei-lin, MA Fei. Association of leukocyte telomere length in peripheral blood and the risk of mild cognitive impairment in elderly subjects:a case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 409-412. doi: 10.16462/j.cnki.zhjbkz.2020.04.008

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Association of leukocyte telomere length in peripheral blood and the risk of mild cognitive impairment in elderly subjects:a case-control study

doi: 10.16462/j.cnki.zhjbkz.2020.04.008

YANG Tong^{1, 2},
WANG Hua-lou^{1, 2},
CHEN Chong³,
ZHAO Hui-chao⁴,
XIONG Ying⁵,
JIA Jing-ya^{1, 2},
ZHANG Mei-lin^{2, 6},
MA Fei^{1, 2
,
,}

1.
Department of Epidemiology and Health Statistics, Faculty of Public Health, Tianjin Medical University, Tianjin 300070, China
2.
Tianjin Key Laboratory of Environmental Nutrition and Population Health, Tianjin 300070, China
3.
Department of Clinical Laboratory, Cancer Hospital, Tianjin Medical University, Tianjin 300060, China
4.
Faculty of Medicine and Humanities, Tianjin Medical University, Tianjin 300070, China
5.
Community Department, Wangdingdi Hospital, Nankai District, Tianjin 300191, China
6.
Department of Nutrition and Food Hygiene, Faculty of Public Health, Tianjin Medical University, Tianjin 300070, China

Funds: National Natural Science Foundation of China(81874261, 81573148)

More Information

Corresponding author: MA Fei, E-mail:mafei@tmu.edu.cn
Received Date: 2019-10-19
Rev Recd Date: 2020-01-09
Publish Date: 2020-04-10

Abstract

Abstract

Objective To explore the relationship between leukocyte telomere length(LTL)in peripheral blood and the risk of mild cognitive impairment(MCI)in elderly subjects. Methods This was a case-control study. Healthy controls and subjects with MCI were recruited from five communities in Wangdingdi Street, Nankai District, Tianjin from October 2017 to December 2017. Questionnaires were conducted and venous blood samples were collected from each subject. LTL was assessed using real-time quantitative polymerase chain reaction assay(qPCR). Multiple logistic regression model was performed to analyze the relationship between LTL for each level group and the risk of MCI. Results A total of 183 participants was enrolled for each group. The level of serum LTL was 1.44±0.23 in the MCI group, which was lower than 1.66±0.23 in the control group(Z=-8.94, P < 0.001). There was a significant correlation between lower levels of LTL and the risk for MCI after adjusting variables for age, gender, education, smoking, alcohol consumption, diabetes, hypertension, and heart disease(allP < 0.05). Compared with the first level group of LTL, the adjusted odds ratio(OR) and 95% confidence interval(95% CI) for the risk of MCI were 0.262(0.130-0.531) for the second level group, 0.088(0.043-0.180) for the third level group, and 0.083(0.040-0.169) for the fourth level group. Conclusions Short leukocyte telomere length in peripheral blood appears to be an independent risk factor for the incidence of MCI. And with the decrease of LTL, the risk of MCI increased.
- Mild cognitive impairment,
- Telomere,
- Case-control study,
- Multiple logistic regression

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References(18)

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