Drug resistance spectrum and characteristics of multi-drug resistant <i>Pseudomonas aeruginosa</i> in patients with pulmonary infection

ZHOU Jun-li; ZHANG Wen-cui; WANG Ying-ying; ZHENG Hui-jie; LIU Ning; LI Ying; HE Sui-ping; GONG Zi-jun; YAO Zhen-jiang

doi:10.16462/j.cnki.zhjbkz.2020.09.011

Volume 24 Issue 9

Sep. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(9): 1046-1050, 1062

ZHOU Jun-li, ZHANG Wen-cui, WANG Ying-ying, ZHENG Hui-jie, LIU Ning, LI Ying, HE Sui-ping, GONG Zi-jun, YAO Zhen-jiang. Drug resistance spectrum and characteristics of multi-drug resistant Pseudomonas aeruginosa in patients with pulmonary infection[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1046-1050, 1062. doi: 10.16462/j.cnki.zhjbkz.2020.09.011

Citation:

ZHOU Jun-li, ZHANG Wen-cui, WANG Ying-ying, ZHENG Hui-jie, LIU Ning, LI Ying, HE Sui-ping, GONG Zi-jun, YAO Zhen-jiang. Drug resistance spectrum and characteristics of multi-drug resistant Pseudomonas aeruginosa in patients with pulmonary infection[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1046-1050, 1062. doi: 10.16462/j.cnki.zhjbkz.2020.09.011

Citation:

ZHOU Jun-li, ZHANG Wen-cui, WANG Ying-ying, ZHENG Hui-jie, LIU Ning, LI Ying, HE Sui-ping, GONG Zi-jun, YAO Zhen-jiang. Drug resistance spectrum and characteristics of multi-drug resistant Pseudomonas aeruginosa in patients with pulmonary infection[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1046-1050, 1062. doi: 10.16462/j.cnki.zhjbkz.2020.09.011

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Drug resistance spectrum and characteristics of multi-drug resistant Pseudomonas aeruginosa in patients with pulmonary infection

doi: 10.16462/j.cnki.zhjbkz.2020.09.011

Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China

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Guangdong Science and Technology Planning Projet 2008B030301034

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Corresponding author: YAO Zhen-jiang ,E-mail:zhjyao2001@yahoo.com
Received Date: 2019-12-17
Rev Recd Date: 2020-04-08
Publish Date: 2020-09-10

Abstract

Abstract

Objective To analyze drug resistance spectrum, production of beta-lactamases, distribution of drug-resistant genes and integrons genes in multi-drug resistant Pseudomonas aeruginosa (MDRPA) isolated from patients with pulmonary infection in Guangzhou City. Methods Antimicrobial susceptibility testing and genetic testing were performed for MDRPA isolates, which were collected from patients with pulmonary infection in five hospitals in Guangzhou from 2008 to 2012. Results Of the 248 Pseudomonas aeruginosa isolates, the prevalance of MDRPA was 58.47%. The resistance rates to antibiotics used were over 50.00%. Among 145 MDRPA strains, the detection rate of production of extended spectrum β-lactamases (ESBLs), metallo β lactamases (MBL) and class C cephalosporinases (AmpC) was 17.93%, 21.38%, 17.24%, respectively. The detection rate of encoding genes was TEM (54.48%), PER (25.52%), OXA-10 (33.79%), IMP (21.38%) and VIM (9.66%), respectively, and the lacking rate of OprD2 gene was 32.41%. The detection rate of aminoglycoside modifying enzyme genes ant(3″)-Ⅰ and aac(6')-Ⅱ was 43.45% and 40.69%, respectively, and class Ⅰ integron gene was 62.07%. Conclusion The multi-drug resistance situation of Pseudomonas aeruginosa in patients with pulmonary infection in Guangzhou is serious. Meanwhile, β-lactamase and its coding genes, class Ⅰ integron genes and a variety of drug resistance genes are widely found in MDRPA, which should be paid more attention to.
- Pseudomonas aeruginosa,
- Pulmonary infection,
- Multi-drug resistance,
- β-lactamase,
- Gene

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References(24)

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