Analysis of influence factors on congenital digestive tract malformation

HOU Guo-qiang; REN Jia-jia; CAO Wen-jun; WANG Li-hong; FANG Zi-wei; WANG Jing-ming

doi:10.16462/j.cnki.zhjbkz.2020.09.020

Volume 24 Issue 9

Sep. 2020

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(9): 1092-1095

HOU Guo-qiang, REN Jia-jia, CAO Wen-jun, WANG Li-hong, FANG Zi-wei, WANG Jing-ming. Analysis of influence factors on congenital digestive tract malformation[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1092-1095. doi: 10.16462/j.cnki.zhjbkz.2020.09.020

Citation:

HOU Guo-qiang, REN Jia-jia, CAO Wen-jun, WANG Li-hong, FANG Zi-wei, WANG Jing-ming. Analysis of influence factors on congenital digestive tract malformation[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1092-1095. doi: 10.16462/j.cnki.zhjbkz.2020.09.020

Citation:

PDF( 832 KB)

Analysis of influence factors on congenital digestive tract malformation

doi: 10.16462/j.cnki.zhjbkz.2020.09.020

1.
Department of Neonatology, Changzhi Maternal and Child Health Care Hospital, Changzhi 046000, China
2.
Department of Preventive Medicine, Changzhi Medical College, Changzhi 046000, China

Funds:

Scientific Research Project of Shanxi Provincial Health Commission RK16

Innovation project for universities in Shanxi Province 2019L0970

More Information

Corresponding author: CAO Wen-jun, E-mail: wjcao16@czmc.edu.cn
Received Date: 2020-02-20
Rev Recd Date: 2020-04-25
Publish Date: 2020-09-10

Abstract

Abstract

Objective To explore risk factors related to congenital digestive tract malformation. Methods From March to April 2019, a self-designed questionnaire was used to investigate parental risk factors before and during pregnancy with digestive tract malformation (n=54, case group) and newborns with non-digestive tract malformation in the same department (n=60, control group) from 2015 to 2018. Results Univariate analysis showed that gender, gestational weeks, birth weight, maternal age, caffeine or multivitamin exposure during pregnancy, age of father and father smoking before 3 months of pregnancy were associated with the occurrence of congenital gastrointestinal malformations. Logistic regression analysis showed that male neonates were at high risk for digestive tract malformation (P < 0.001, OR=7.168). Multivitamin supplementation during pregnancy was a protective factor for digestive tract malformation (P=0.004, OR=0.103). Fathers smoking greater than 5/day before 3 months of pregnancy was a risk factor for digestive tract malformations (P=0.005, OR=2.833). Conclusions Male neonates, fathers smoking greater than 5/day before 3 months of pregnancy were high risk factors for digestive tract malformation and multivitamin supplementation during pregnancy was a protective factor for digestive tract malformation.
- Digestive tract malformation,
- Risk assessment,
- Influencing factors

FullText(HTML)

References(15)

References

[1]	蒲昭和.导致婴儿畸形的环境因素[J].首都医药, 2002, (11):33. DOI: 10.3969/j.issn.1005-8257.2002.11.016. Pu ZH. Environmental factors leading to infant malformation [J]. Capital Medicine, 2002, (11):33. DOI: 10.3969/j.issn.1005-8257.2002.11.016.
[2]	Zwink N, Rissmann A, P tzsch S, et al. Parental risk factors of anorectal malformations: analysis with a regional population-based control group [J]. Birth Defects Res, 2016, 106(2):133-141. DOI: 10.1002/bdra.23469.
[3]	宋玮婷, 韦云飞, 张凤珍.母亲年龄与胎儿出生缺陷的关系[J].中国儿童保健杂志, 2012, 20(9):855-857. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgetbjzz201209028 Song WT, Wei YF, Zhang FZ. The relationship between maternal age and fetal birth defects [J]. Chin J Child Heal Care, 2012, 20(9):855-857. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgetbjzz201209028
[4]	高平明, 高晓燕, 黄润忠.先天性消化道畸形的影响因素分析[J].重庆医学, 2016, 45(36):5142-5144. DOI: 10.3969/j.issn.1671-8348.2016.36.032. PM, Gao XY, Huang RZ. Analysis on influencing factors of congenital digestive tract malformation [J]. Chongqing Medicine, 2016, 45(36):5142-5144. DOI: 10.3969/j.issn.1671-8348.2016.36.032.
[5]	Van Rooij IA, Wijers CH, Rieu PN, et al. Maternal and paternal risk factors for anorectal malformations: a Dutch case-control study [J]. Birth Defects Res, 2010, 88(3):152-158. DOI: 10.1002/bdra.20649.
[6]	Zwink N. Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis [J]. Orphanet J Rare Dis, 2018, 13(1):75. DOI: 10.1186/s13023-018-0789-3.
[7]	Honein MA, Paulozzi LJ. Maternal smoking and birth defects: validity of birth certificate data for effect estimation [J]. Public Health Rep, 2001, 116(4):327-335. DOI: 10.1093/phr/116.4.327.
[8]	林紫晴, 成宇璐, 罗慧, 等.床边超声对新生儿先天性消化道畸形的诊断价值[J].中国实用医药, 2020, 15(10):59-61. DOI: 10.14163/j.cnki.11-5547/r.2020.10.024. Lin ZQ, Chen YL, Luo H, et al. The diagnostic value of bedside ultrasound for neonatal congenital gastrointestinal malformations [J]. China Prac Med, 2020, 15(10):59-61. DOI: 10.14163/j.cnki.11-5547/r.2020.10.024.
[9]	Olgun H, Karacan M, Caner I, et al. Congenital cardiac malformations in neonates with apparently isolated gastrointestinal malformations [J]. Pediatr Int, 2009, 51(2):260-262. DOI: 10.1111/j.1442-200X.2008.02711.x.
[10]	宋伟, 刘晓巍, 张涛, 等. 9 638例不同年龄阶段孕妇产前诊断结果分析[J].中国妇幼保健, 2017, 32(17):4064-4067. DOI: 10.7620/zgfybj.j.issn.1001-4411.2017.17.16. Song W.Liu XW, Zhang T. Analysis on the results of prenatal diagnosis in 9 638 pregnant women in different age groups [J]. Maternal and Child Health Care of China, 2017, 32(17):4064-4067. DOI: 10.7620/zgfybj.j.issn.1001-4411.2017.17.16.
[11]	Yang Q, Wen SW, Leader A, et al. Paternal age and birth defects: how strong is the association? [J]. Hum Reprod, 2007, 22(3):696-701. DOI: 10.1093/humrep/del453.
[12]	曹卉娟, 刘建平.孕期咖啡因摄入与流产相关性分析性研究系统综述[J].中国实用妇科与产科杂志, 2014, 30(12):945-950. DOI: 10.7504/fk2014110111. Cao HJ, Liu JP. A systematic review of analytical studies on relationship between caffeine intake during pregnancy and spontaneous abortion [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2014, 30(12):945-950. DOI: 10.7504/fk2014110111.
[13]	陈丽玉, 蔡际, 张其清.维生素与胎儿发育的关系[J].国际生殖健康/计划生育杂志, 2017, 36(1):78-81. DOI: 10.3969/j.issn.1001-0203.2018.04.010. Chen LY, Cai J, Zhang QQ. Relationship between vitamin and fetal development [J]. J Int Reprod Health/Fam Plan, 2017, 36(1):78-81. DOI: 10.3969/j.issn.1001-0203.2018.04.010.
[14]	Zwink N, Jenetzky E. Parental risk factors and anorectal malformations: systematic review and meta-analysis [J]. Orphanet J Rare Dis diseases, 2011, 6(1):25. DOI: 10.1186/1750-1172-6-25.
[15]	张明, 董春萍, 赵永琴, 等. 2011~2013年诸城市新生儿先天畸形检出率及危险因素分析[J].中国妇幼保健, 2014, 29(20):3298-3300. DOI: 10.7620/zgfybj.j.issn.1001-4411.2014.20.35.ZhangM, Dong CP, Zhao YQ, et al. Analysis on detection rate and risk factors of congenital malformations among neonates in Zhucheng city from 2011 to 2013 [J]. Maternal and Child Health Care of China, 2014, 29(20):3298-3300. DOI: 10.7620/zgfybj.j.issn.1001-4411.2014.20.35.