The association between metabolic syndrome and the risk of gallstones among premenopausal and postmenopausal women

WU Shui-lin; QIN Jia-li; LI Yong; MAO Xue-qian; ZHOU Yue; YANG Jing-li; BAI Ya-na

doi:10.16462/j.cnki.zhjbkz.2021.06.012

Volume 25 Issue 6

Jul. 2021

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WU Shui-lin, QIN Jia-li, LI Yong, MAO Xue-qian, ZHOU Yue, YANG Jing-li, BAI Ya-na. The association between metabolic syndrome and the risk of gallstones among premenopausal and postmenopausal women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 686-691. doi: 10.16462/j.cnki.zhjbkz.2021.06.012

Citation:

WU Shui-lin, QIN Jia-li, LI Yong, MAO Xue-qian, ZHOU Yue, YANG Jing-li, BAI Ya-na. The association between metabolic syndrome and the risk of gallstones among premenopausal and postmenopausal women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 686-691. doi: 10.16462/j.cnki.zhjbkz.2021.06.012

Citation:

WU Shui-lin, QIN Jia-li, LI Yong, MAO Xue-qian, ZHOU Yue, YANG Jing-li, BAI Ya-na. The association between metabolic syndrome and the risk of gallstones among premenopausal and postmenopausal women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 686-691. doi: 10.16462/j.cnki.zhjbkz.2021.06.012

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The association between metabolic syndrome and the risk of gallstones among premenopausal and postmenopausal women

doi: 10.16462/j.cnki.zhjbkz.2021.06.012

Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China

WU Shui-lin and QIN Jia-li contributed equally to this article

Funds:

Construction of the Whole-Process Management System for Metabolic Diseases 5among Staffs in Jinchuan Group Co Ltd Jinkezong2020-02

More Information

Corresponding author: YANG Jing-li, E-mail: yangjl18@lzu.edu.cn; BAI Ya-na, E-mail: baiyana@lzu.edu.cn
Received Date: 2020-12-08
Rev Recd Date: 2021-01-28
Publish Date: 2021-06-10

Abstract

Abstract

Objective To analysis the incidence of gallstones among women in Jingchang cohort, and explore the relationship of metabolic syndrome and its components with the risk of gallstones among premenopausal and postmenopausal women. Methods A prospective cohort study was conducted to investigate the effects of metabolic syndrome and its components on the incidence of gallstones in women who did not have gallstones from baseline data. Results A total of 4 196 women were included in this study, and 195 (4.65%) had gallstones in follow-up. The incidence of gallstones in postmenopausal women with metabolic syndrome (10.91%) was higher than that in women without metabolic syndrome (5.68%, χ² ＝19.982, P < 0.001). With the increase of the number of abnormal components, the incidence of gallstones gradually increased (χ² _trend＝30.340, P < 0.001), and reached the maximum when multiple metabolic components were abnormal (12.24%). After adjusting for confounding factors, the risk of gallstones in postmenopausal women with multiple metabolic abnormalities was 6.839 times higher than that in the normal population (95% CI: 1.665-28.084, P＝0.008). The incidence of gallstones in people with abnormal waist circumference, TG, HDL-C, FPG were higher than those in normal subjects among postmenopausal women (all P < 0.05). After adjusting for confounding factors, the risk of gallstones in postmenopausal women with abnormal waist circumference (HR=1.805, 95% CI: 1.204-2.704, P＝0.004) and HDL-C (HR=1.451, 95%CI: 1.071-1.965, P＝0.016) were still higher than that in the normal population. In the grouping of metabolic syndrome, the abnormal number of metabolic syndrome and the normal or abnormal grouping of each component, the incidence of gallstones in postmenopausal women was higher than that in premenopausal women (all P < 0.05). Conclusion The incidence of gallstones in postmenopausal women is related to metabolic syndrome, and the incidence of gallstones in women is affected by menopausal status.
- Jinchang cohort,
- Gallstone,
- Metabolic syndrome

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References(13)

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