A cohort study on the effect of pre-onset physical exercise mediated by serum superoxide dismutase on improving the cognitive function of patients with ischemic stroke

YU Ying; CAI Ben; LYU Heng; CHU Yi-fan; ZHANG Li-na; JIA Xian-jie

doi:10.16462/j.cnki.zhjbkz.2021.11.012

Volume 25 Issue 11

Nov. 2021

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YU Ying, CAI Ben, LYU Heng, CHU Yi-fan, ZHANG Li-na, JIA Xian-jie. A cohort study on the effect of pre-onset physical exercise mediated by serum superoxide dismutase on improving the cognitive function of patients with ischemic stroke[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1303-1308. doi: 10.16462/j.cnki.zhjbkz.2021.11.012

Citation:

YU Ying, CAI Ben, LYU Heng, CHU Yi-fan, ZHANG Li-na, JIA Xian-jie. A cohort study on the effect of pre-onset physical exercise mediated by serum superoxide dismutase on improving the cognitive function of patients with ischemic stroke[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1303-1308. doi: 10.16462/j.cnki.zhjbkz.2021.11.012

Citation:

YU Ying, CAI Ben, LYU Heng, CHU Yi-fan, ZHANG Li-na, JIA Xian-jie. A cohort study on the effect of pre-onset physical exercise mediated by serum superoxide dismutase on improving the cognitive function of patients with ischemic stroke[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1303-1308. doi: 10.16462/j.cnki.zhjbkz.2021.11.012

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A cohort study on the effect of pre-onset physical exercise mediated by serum superoxide dismutase on improving the cognitive function of patients with ischemic stroke

doi: 10.16462/j.cnki.zhjbkz.2021.11.012

1.
Department of Physiology, School of Basic Medicine, Bengbu Medical College, Bengbu 233000, China
2.
Department of Epidemiology and Health Statistics, School of Public Health, Bengbu Medical College, Bengbu 233000, China
3.
Department of Neurology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233003, China

Funds:

Natural Science Foundation of Anhui Province 2108085MH252

Natural Science of the Education Department of Anhui Province KJ2019A0306

Transformation of Medicine Research Projects of Bengbu Medical College BYTM2019004

512 Talent Cultivation Plan of Bengbu Medical College by51201202

512 Talent Cultivation Plan of Bengbu Medical College by51201307

More Information

Corresponding author: JIA Xian-jie, E-mail: xjjia@139.com
Received Date: 2021-04-21
Rev Recd Date: 2021-07-13

Available Online: 2021-12-04

Publish Date: 2021-11-10

Abstract

Abstract

Objective To explore the impact of pre-ischemic stroke physical exercise on the short-term prognosis of cognitive function in patients with first ischemic stroke and the mediating role of serum SOD on this effect. Methods In this study, 512 patients who were first-onset diagnosed with ischemic stroke in the department of neurology of the first affiliated hospital of Bengbu Medical College were selected for a short-term cohort study from July 1, 2018 to November 30, 2019. A questionnaire was used to investigate the physical activity-related variables before the onset of the disease, and the modified montreal cognitive assessment (MoCA) scale was used for cognitive function measurement and follow-up evaluation. Logistic regression analysis model was adopted to analyze the effect of physical exercise on the short-term prognosis of cognitive function. The bootstrap method was used to analyze the mediation role of serum SOD. Results Compared with the non-exercise group, the patients who exercised ≥ 3 d a week, exercised at least once a day, and exercised 30~ < 60 min per day for more than 1 year had higher MoCA scale scores at 3, 6, and 12 months after discharge. The effect of physical exercise on cognitive function rehabilitation decreased continuously after follow-up for 3 months, 6 months, and 12 months, and the modification effect of serum SOD was evident at 3 months and 6 months. The mediation effect of serum SOD in promoting the short-term prognosis of cognitive function of ischemic stroke patients by physical exercise was significant, with a mediation effect of about 10%. Conclusion Pre-ischemic stroke regular physical exercise is a protective factor for the recovery of cognitive function after discharge from ischemic stroke, and its mechanism is correlated with serum SOD.
- Ischemic stroke,
- Physical exercise,
- Cognitive function,
- Serum superoxide dismutase,
- Cohort study

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References(19)

References

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