Epidemiology of dengue virus serotype 4 cases and E gene analysis of dengue virus in Guangzhou Province from 2010 to 2019

JIANG Li-yun; LIU Yuan; SU Wen-zhe; LUO Lei; CAO Yi-min; DI Biao; WU Xin-wei; ZHANG Zhou-bin

doi:10.16462/j.cnki.zhjbkz.2021.11.022

Volume 25 Issue 11

Nov. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(11): 1360-1364

JIANG Li-yun, LIU Yuan, SU Wen-zhe, LUO Lei, CAO Yi-min, DI Biao, WU Xin-wei, ZHANG Zhou-bin. Epidemiology of dengue virus serotype 4 cases and E gene analysis of dengue virus in Guangzhou Province from 2010 to 2019[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1360-1364. doi: 10.16462/j.cnki.zhjbkz.2021.11.022

Citation:

JIANG Li-yun, LIU Yuan, SU Wen-zhe, LUO Lei, CAO Yi-min, DI Biao, WU Xin-wei, ZHANG Zhou-bin. Epidemiology of dengue virus serotype 4 cases and E gene analysis of dengue virus in Guangzhou Province from 2010 to 2019[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1360-1364. doi: 10.16462/j.cnki.zhjbkz.2021.11.022

Citation:

JIANG Li-yun, LIU Yuan, SU Wen-zhe, LUO Lei, CAO Yi-min, DI Biao, WU Xin-wei, ZHANG Zhou-bin. Epidemiology of dengue virus serotype 4 cases and E gene analysis of dengue virus in Guangzhou Province from 2010 to 2019[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1360-1364. doi: 10.16462/j.cnki.zhjbkz.2021.11.022

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Epidemiology of dengue virus serotype 4 cases and E gene analysis of dengue virus in Guangzhou Province from 2010 to 2019

doi: 10.16462/j.cnki.zhjbkz.2021.11.022

Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China

Funds:

Guangzhou Science and Technology Department Program 202002030117

Bureau of Health of Guangzhou Municipality 20191A011059

Basic Research Project of Key Laboratory of Guangzhou 2021BRP004

Key Project of Medicine Discipline of Guangzhou 2021-2023-11

More Information

Corresponding author: JIANG Li-yun, E-mail: year800325@163.com
Received Date: 2021-01-07
Rev Recd Date: 2021-03-01

Available Online: 2021-12-04

Publish Date: 2021-11-10

Abstract

Abstract

Objective Investigate epidemiology of dengue virus serotype 4 cases, and molecular biological characteristics of dengue virus serotype 4 circulating in Guangzhou from 2010 to 2019. Methods Information and serum samples of dengue patients were collected. Serotypes were confirmed by real-time PCR. Envelope (E) gene of dengue virus serotype 4 was sequenced. Phylogenetic tree was constructed, and recombination was analyzed. Results A total of 43 174 dengue cases were reported in Guangzhou between 2010 and 2019, of which 23 cases were confirmed as serotype 4. Serotype 4 cases can only be detected in 5 districts. An endemic of dengue virus serotype 4 broke out in 2010. The imported cases were mainly from Southeast Asia. Sequences of E gene had a high similarity with sequences from Southeast Asia. Sequences acquired in Guangzhou clustered into Indonesia genotype and Southeast Asia genotype. No recombination has been detected. Conclusions Supervision on dengue virus serotype 4 cases and imported cases should be enforced. Conduct propaganda of knowledge about dengue fever and personal protection should be further done among people coming back from Southeast Asia. Dengue virus serotype 4 must be prevented from spreading, especially in some districts. The genotype shift didn't cause any change of epidemic. Although there was no sign of recombination, further research is needed.
- Dengue fever,
- Epidemiological characteristics,
- Envelope gene,
- Phylogenetic tree

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References(22)

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