Mediating effect of body mass index and waist circumference on the relationship between obstructive sleep apnea and type 2 diabetes

CHEN Shu-ting; WANG Jia-le; WANG Ju-ping; GAO Qian; LIANG Jie; WANG Tong

doi:10.16462/j.cnki.zhjbkz.2022.05.006

Volume 26 Issue 5

May 2022

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CHEN Shu-ting, WANG Jia-le, WANG Ju-ping, GAO Qian, LIANG Jie, WANG Tong. Mediating effect of body mass index and waist circumference on the relationship between obstructive sleep apnea and type 2 diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 523-528. doi: 10.16462/j.cnki.zhjbkz.2022.05.006

Citation:

CHEN Shu-ting, WANG Jia-le, WANG Ju-ping, GAO Qian, LIANG Jie, WANG Tong. Mediating effect of body mass index and waist circumference on the relationship between obstructive sleep apnea and type 2 diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 523-528. doi: 10.16462/j.cnki.zhjbkz.2022.05.006

Citation:

CHEN Shu-ting, WANG Jia-le, WANG Ju-ping, GAO Qian, LIANG Jie, WANG Tong. Mediating effect of body mass index and waist circumference on the relationship between obstructive sleep apnea and type 2 diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 523-528. doi: 10.16462/j.cnki.zhjbkz.2022.05.006

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Mediating effect of body mass index and waist circumference on the relationship between obstructive sleep apnea and type 2 diabetes

doi: 10.16462/j.cnki.zhjbkz.2022.05.006

Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan 030001, China

Funds:

National Natural Science Foundation of China 82073674

National Natural Science Foundation of China 81872715

The Grant of the Major Science and Technology Project of Shanxi Province 202102130501003

The Grant of the Major Science and Technology Project of Shanxi Province 202005D121008

More Information

Corresponding author: WANG Tong, E-mail: tongwang@sxmu.edu.cn
Received Date: 2021-11-08
Rev Recd Date: 2022-02-22

Available Online: 2022-05-11

Publish Date: 2022-05-10

Abstract

Abstract

Objective To evaluate the mediating effect of BMI and waist circumference (WC)on the relationships between obstructive sleep apnea (OSA) and type 2 diabetes and continuous measures of glucose metabolism. Methods A total of 1 615 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) were included in this cross-sectional study. OSA severity was assessed by apnea-hypopnea index (AHI), which was measured by polysomnography. Continuous measures of glucose metabolism were FPG and glycated hemoglobin (HbA1c). And obesity indexes used in this study included general obesity (BMI) and abdominal obesity (WC). Results OSA was significantly associated with type 2 diabetes. With increasing the severity of OSA, there was a significant increase in the risk of type 2 diabetes (P < 0.001). Mediation analysis showed that BMI and WC mediated the association between severe OSA and type 2 diabetes, respectively. The indirect effect mediated by WC and BMI were 1.296 (95% CI: 1.182-1.466) and 1.291 (95% CI: 1.173-1.479), and the proportion of mediation were 56.397% and 55.400%, respectively. Similarly, BMI and WC mediated the associations between OSA and FPG and HbA1c. Conclusions These findings show that the associations between OSA and type 2 diabetes, FPG and HbA1c are mediated by obesity indexes to a large proportion. It is suggested that weight control, especially reducing abdominal obesity, may have an important role for OSA patients in decreasing the risk of type 2 diabetes and related cardiovascular complications.
- Obstructive sleep apnea syndrome,
- Type 2 diabetes,
- Mediation analysis,
- Obesity

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References(26)

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