Study on the association of three TC/HDL-C, TG/HDL-C and LDL-C/HDL-C lipid ratios with insulin resistance, diabetes and pre-diabetes

XIN Peng; LI Jing; LI Chang-kun; FAN Li-li; ZHENG Wen-long; WANG De-zheng

doi:10.16462/j.cnki.zhjbkz.2022.05.008

Volume 26 Issue 5

May 2022

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XIN Peng, LI Jing, LI Chang-kun, FAN Li-li, ZHENG Wen-long, WANG De-zheng. Study on the association of three TC/HDL-C, TG/HDL-C and LDL-C/HDL-C lipid ratios with insulin resistance, diabetes and pre-diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 535-540. doi: 10.16462/j.cnki.zhjbkz.2022.05.008

Citation:

XIN Peng, LI Jing, LI Chang-kun, FAN Li-li, ZHENG Wen-long, WANG De-zheng. Study on the association of three TC/HDL-C, TG/HDL-C and LDL-C/HDL-C lipid ratios with insulin resistance, diabetes and pre-diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 535-540. doi: 10.16462/j.cnki.zhjbkz.2022.05.008

Citation:

XIN Peng, LI Jing, LI Chang-kun, FAN Li-li, ZHENG Wen-long, WANG De-zheng. Study on the association of three TC/HDL-C, TG/HDL-C and LDL-C/HDL-C lipid ratios with insulin resistance, diabetes and pre-diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 535-540. doi: 10.16462/j.cnki.zhjbkz.2022.05.008

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Study on the association of three TC/HDL-C, TG/HDL-C and LDL-C/HDL-C lipid ratios with insulin resistance, diabetes and pre-diabetes

doi: 10.16462/j.cnki.zhjbkz.2022.05.008

Institute of Non-communicable Disease Control and Prevention, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China

Funds:

Project for Selection of Senior Health Talents in Tianjin 2018

More Information

Corresponding author: ZHENG Wen-long, E-mail: zhengwenlong2006@126.com; WANG De-zheng, E-mail: wangdezheng1001@163.com
Received Date: 2021-04-20
Rev Recd Date: 2021-07-09

Available Online: 2022-05-11

Publish Date: 2022-05-10

Abstract

Abstract

Objective To study the association between the ratios of lipid TC/HDL-C, TG/HDL-C and LDL-C/HDL-C and insulin resistant diabetes and pre-diabetes in adults in Tianjin City, in order to explore the evaluation value of lipid ratios levels in public health prevention, clinical diagnosis and disease prediction of diabetes. Methods According to the Chinese adult chronic disease and nutrition surveillance program, inhabitants aged 18 years and above were investigated in 7 Districts including Hexi District in Tianjin City. And their fasting venous blood was collected to detect four blood lipids, fasting plasma glucose and insulin. TC/HDL-C, TG/HDL-C, LDL-C/HDL-C levels were Divided into four groups according to the quartile method, and the OR value, 95% CI with insulin resistance, diabetes and pre-diabetes were analyzed use binary Logistic regression analysis model. Results The prevalence of diabetes combined with pre-diabetes in the investigated population in Tianjin was 46.6% (2 030/4 356). The elevation of TC/HDL-C and TG/HDL-C increased the risk of insulin resistance in the participants, but limited to the LDL-C/HDL-C ≥2.86 group, the risk of insulin resistance increased by 1.78 (95% CI: 1.21-2.63) times when compared with the ratio < 1.78 group. With the increase of TC/HDL-C and TG/HDL-C, the risk of diabetes and pre-diabetes increased in both men and women, and the correlation was strong, and the correlation with LDL-C/HDL-C was lower than that of TC/HDL-C and TG/HDL-C. In addition, it was found that the increase of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C had a stronger effect on increasing the risk of diabetes and pre-diabetes in females compared to males. Conclusions The increase of TC/HDL-C and TG/HDL-C can increase the risk of insulin resistance, diabetes and pre-diabetes. LDL-C/HDL-C is weakly associated with the risk of insulin resistance, diabetes and pre-diabetes.
- Insulin resistance,
- Diabetes,
- Pre-diabetes,
- Lipid ratios

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References(22)

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