Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children

LIN Wan-jing; SHAO Xue-jun; ZHANG Jun; TAO Yun-zhen; FENG Shuang; ZHANG You-yi; CHEN Qing-hui; TIAN Jian-mei; ZHAO Gen-ming; ZHANG Tao

doi:10.16462/j.cnki.zhjbkz.2022.05.013

Volume 26 Issue 5

May 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(5): 565-570

LIN Wan-jing, SHAO Xue-jun, ZHANG Jun, TAO Yun-zhen, FENG Shuang, ZHANG You-yi, CHEN Qing-hui, TIAN Jian-mei, ZHAO Gen-ming, ZHANG Tao. Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 565-570. doi: 10.16462/j.cnki.zhjbkz.2022.05.013

Citation:

LIN Wan-jing, SHAO Xue-jun, ZHANG Jun, TAO Yun-zhen, FENG Shuang, ZHANG You-yi, CHEN Qing-hui, TIAN Jian-mei, ZHAO Gen-ming, ZHANG Tao. Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 565-570. doi: 10.16462/j.cnki.zhjbkz.2022.05.013

Citation:

LIN Wan-jing, SHAO Xue-jun, ZHANG Jun, TAO Yun-zhen, FENG Shuang, ZHANG You-yi, CHEN Qing-hui, TIAN Jian-mei, ZHAO Gen-ming, ZHANG Tao. Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 565-570. doi: 10.16462/j.cnki.zhjbkz.2022.05.013

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Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children

doi: 10.16462/j.cnki.zhjbkz.2022.05.013

1.
Department of Epidemiology, School of Public Health, Fudan University, Key Laboratory of Public Health Safety Ministry of Education, Shanghai 200032, China
2.
Infectious Disease Department, Soochow University Affiliated Children's Hospital, Suzhou 215003, China
3.
Department of Clinical Laboratory Soochow University Affiliated Children's Hospital, Suzhou 215003, China
4.
Suzhou Centers for Disease Control and Prevention, Suzhou 215003, China

Funds:

Pfizer Clinical Research Collaboration W1232403

More Information

Corresponding author: ZHANG Tao, E-mail: tzhang@shmu.edu.cn
Received Date: 2021-08-20
Rev Recd Date: 2022-01-13

Available Online: 2022-05-11

Publish Date: 2022-05-10

Abstract

Abstract

Objective To investigate the serotype distribution and antibiotic-resistance of Streptococcus pneumoniae (S. pneumoniae) isolated from medical-visiting children, and to explore the effect of 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal isolates. Methods The strains of S. pneumoniae isolated from children with confirmed vaccination information in Soochow University Affiliated Children's Hospital (SCH) from 2017 to 2019 were collected. The strains were grouped according to the vaccination status, used quellung reactions to serotype and employed E-test method to determine the antibiotic resistance of strains, and compared the differences in serotypes and antibiotic-resistance between with and without PCV13 vaccination. Results A total of 692 strains of S. pneumoniae were collected, 20 of which were isolated from children vaccinated with PCV13. Serotypes 19F, 6B, 19A and 23F were prevalent in vaccinated children, while serotypes 19F, 6B, 23F, 19A and 14 were common in unvaccinated children. There was no significant difference between the two groups in serotype distribution (P=0.868), and the PCV13 serotype coverage was 70.0% and 72.4%, respectively (P=0.491). All strains were highly resistant to erythromycin, tetracycline and clindamycin, and the multi-antibiotic resistance rate was 98.5%. The unsusceptible rates of penicillin were 5.0% and 9.1% in the vaccinated and unvaccinated groups, respectively (P=0.804). Conclusions Most S. pneumoniae strains from children in SCH were covered by PCV13 serotypes. The resistance of S. pneumoniae to lactams antibiotics was decreased, but the resistance to other commonly used antibiotics such as erythromycin remained severe, and the multi-antibiotic resistance rate was high. No apparent effect of PCV13 on serotype distribution and antibiotic resistance was observed.
- Streptococcus pneumoniae,
- 13-valent pneumococcal conjugate vaccine,
- Serotype,
- Antimicrobial resistance,
- Children

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References(19)

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