Distribution of HIV-1 genotypes and its association with first CD4<sup>+</sup>T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020

LI Jian-jun; CHEN Yan-lan; GE Xian-min; CEN Ping; LAN Guang-hua; YANG Shi-xiong; LIANG Shu-jia; TANG Kai-ling; FANG Ning-ye; PANG Xian-wu; HE Qin; LIN Zhao-sen; GUO Wei-gui; DENG Xin-hui; FENG Xian-xiang; ZHOU Li-fang; HUANG Yun-xuan; YANG Dong; MO Jing-lin; ZHONG Jian; MO Hong-zhi; NONG Ai-dan; LIANG Xu; QIN Xi-mao; MO Shi-de; ZENG Zi; LUO Liu-hong; CHEN Huan-huan; ZHU Qiu-ying; ZHU Jin-hui; LU Hua-xiang; MENG Qin; LIU Shuai-feng; LI Bo

doi:10.16462/j.cnki.zhjbkz.2022.12.005

Volume 26 Issue 12

Dec. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(12): 1389-1394

LI Jian-jun, CHEN Yan-lan, GE Xian-min, CEN Ping, LAN Guang-hua, YANG Shi-xiong, LIANG Shu-jia, TANG Kai-ling, FANG Ning-ye, PANG Xian-wu, HE Qin, LIN Zhao-sen, GUO Wei-gui, DENG Xin-hui, FENG Xian-xiang, ZHOU Li-fang, HUANG Yun-xuan, YANG Dong, MO Jing-lin, ZHONG Jian, MO Hong-zhi, NONG Ai-dan, LIANG Xu, QIN Xi-mao, MO Shi-de, ZENG Zi, LUO Liu-hong, CHEN Huan-huan, ZHU Qiu-ying, ZHU Jin-hui, LU Hua-xiang, MENG Qin, LIU Shuai-feng, LI Bo. Distribution of HIV-1 genotypes and its association with first CD4+T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

Citation:

LI Jian-jun, CHEN Yan-lan, GE Xian-min, CEN Ping, LAN Guang-hua, YANG Shi-xiong, LIANG Shu-jia, TANG Kai-ling, FANG Ning-ye, PANG Xian-wu, HE Qin, LIN Zhao-sen, GUO Wei-gui, DENG Xin-hui, FENG Xian-xiang, ZHOU Li-fang, HUANG Yun-xuan, YANG Dong, MO Jing-lin, ZHONG Jian, MO Hong-zhi, NONG Ai-dan, LIANG Xu, QIN Xi-mao, MO Shi-de, ZENG Zi, LUO Liu-hong, CHEN Huan-huan, ZHU Qiu-ying, ZHU Jin-hui, LU Hua-xiang, MENG Qin, LIU Shuai-feng, LI Bo. Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

Citation:

LI Jian-jun, CHEN Yan-lan, GE Xian-min, CEN Ping, LAN Guang-hua, YANG Shi-xiong, LIANG Shu-jia, TANG Kai-ling, FANG Ning-ye, PANG Xian-wu, HE Qin, LIN Zhao-sen, GUO Wei-gui, DENG Xin-hui, FENG Xian-xiang, ZHOU Li-fang, HUANG Yun-xuan, YANG Dong, MO Jing-lin, ZHONG Jian, MO Hong-zhi, NONG Ai-dan, LIANG Xu, QIN Xi-mao, MO Shi-de, ZENG Zi, LUO Liu-hong, CHEN Huan-huan, ZHU Qiu-ying, ZHU Jin-hui, LU Hua-xiang, MENG Qin, LIU Shuai-feng, LI Bo. Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

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Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020

doi: 10.16462/j.cnki.zhjbkz.2022.12.005

1.
Institute of HIV/AIDS Prevention and Control, Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning 530028, China
2.
Department of HIV/AIDS Prevention and Control, Qinzhou Center for Disease Control and Prevention, Qinzhou 535099, China
3.
Department of HIV/AIDS/STD Prevention and Control, Nanning Center for Disease Control and Prevention, Nanning 530023, China
4.
Department of HIV/AIDS/STD Prevention and Control, Beihai Center for Disease Control and Prevention, Beihai 536000, China
5.
Department of HIV/AIDS Prevention and Control, Laibin Center for Disease Control and Prevention, Laibin 546100, China
6.
Institute of HIV/AIDS Prevention and Control, Liuzhou Center for Disease Control and Prevention, Liuzhou 545007, China
7.
Department of HIV/AIDS Prevention and Control, Guigang Center for Disease Control and Prevention, Guigang 537100, China
8.
Department of HIV/AIDS/STD Prevention and Control, Guilin Center for Disease Control and Prevention, Guilin 541001, China
9.
Department of HIV/AIDS Prevention and Control, Wuzhou Center for Disease Control and Prevention, Wuzhou 543002, China
10.
Department of HIV/AIDS/STD Prevention and Control, Hechi Center for Disease Control and Prevention, Hechi 547000, China
11.
Department of HIV/AIDS/STD Prevention and Control, Chongzuo Center for Disease Control and Prevention, Chongzuo 532200, China
12.
Department of HIV/AIDS/STD Prevention and Control, Baise Center for Disease Control and Prevention, Baise 533000, China
13.
Department of HIV/AIDS Prevention and Control, Yulin Center for Disease Control and Prevention, Yulin 537000, China
14.
Department of HIV/AIDS Prevention and Control, Fangchenggang Center for Disease Control and Prevention, Fangchenggang 538021, China
15.
Department of HIV/AIDS Prevention and Control, Hezhou Center for Disease Control and Prevention, Hezhou 542899, China

LI Jian-jun and CHEN Yan-lan contributed equally to the article

Funds:

Guangxi Focus on research and development projects AB19245044

Guangxi Natural Science Foundation Project 2020GXNSFAA159020

Guangxi Bagui Honor Scholarship [2019] No.79 issued by the General Office of GUI

Guangxi Key Laboratory of AIDS Prevention Control and Translation ZZH2020010

More Information

Corresponding author: GE Xian-min, E-mail: gxgexm@sina.com; CEN Ping, E-mail: cenping877@163.com
Received Date: 2022-09-21
Rev Recd Date: 2022-10-31

Available Online: 2022-12-30

Publish Date: 2022-12-10

Abstract

Abstract

Objective To analyze the compositional characteristics of HIV-1 genotype among HIV-infected men aged 50 and over (referred to as middle-aged and elderly men) newly reported in Guangxi in 2020, and to analyze the association between different genotypes and the CD4⁺ T lymphocyte(referred to as CD4) count at HIV diagnosis. Methods The stratified random sampling method was used to select middle-aged and elderly male HIV-infected patients in 2020 newly reported in 14 cities in Guangxi as the research subjects, and the plasma of infected patients was subjected to viral RNA extraction, reverse transcription amplification, sequencing, HIV-1 genotype and sub-cluster determination. A multivariate model was used to evaluate possible statistically associated influencing factors of CD4 counts. Results A total of 606 HIV-infected patients were included and analyzed, and the main circulating strains were CRF01_AE, CRF07_BC and CRF08_BC, and their proportions were 57.6%(349/606), 17.2%(104/606) and 22.1%(134/606) respectively, and the medians of their first CD4 at diagnosis were 145(51, 271), 212(110, 330) and 178(100, 307) cells/μL, respectively. The first CD4 count at diagnosis of CRF01_AE infected patients was lower than that of CRF07_BC infected patients(Z=-3.363, P=0.002), and lower than that of CRF08_BC infected patients(Z=-2.983, P=0.009). Binary logistic regression model showed that CRF01_AE was an independent risk factor for CD4 ≤200 cells/μL among newly reported middle-aged and elderly men with HIV infection in Guangxi(aOR=1.453, 95% CI: 1.047-2.017). Conclusions CRF01_AE, CRF07_BC and CRF08_BC are the three main circulating strains of HIV infection among middle-aged and elderly males newly reported in Guangxi in 2020, and major in CRF01_AE. CRF01_AE is an independent risk factor for CD4 ≤200 cells/μL, suggesting that the disease progresses rapidly in middle-aged and elderly men with CRF01_AE strain, which is more harmful to the HIV/AIDS epidemic in Guangxi.
- HIV,
- Middle-aged and elderly men,
- Genetic subtypes,
- CD4⁺T cell counts

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References(17)

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