Study on factors influencing gut microbiota α diversity in the older people

YIN Zhao-xue; BAI Xue-mei; ZHANG Jing-rui; JIANG Yuan-jing; YAN Fei; MUKARAM·Yunus; GAO Xin; WU Jing

doi:10.16462/j.cnki.zhjbkz.2022.12.012

Volume 26 Issue 12

Dec. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(12): 1433-1437

YIN Zhao-xue, BAI Xue-mei, ZHANG Jing-rui, JIANG Yuan-jing, YAN Fei, MUKARAM·Yunus, GAO Xin, WU Jing. Study on factors influencing gut microbiota α diversity in the older people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1433-1437. doi: 10.16462/j.cnki.zhjbkz.2022.12.012

Citation:

YIN Zhao-xue, BAI Xue-mei, ZHANG Jing-rui, JIANG Yuan-jing, YAN Fei, MUKARAM·Yunus, GAO Xin, WU Jing. Study on factors influencing gut microbiota α diversity in the older people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1433-1437. doi: 10.16462/j.cnki.zhjbkz.2022.12.012

Citation:

YIN Zhao-xue, BAI Xue-mei, ZHANG Jing-rui, JIANG Yuan-jing, YAN Fei, MUKARAM·Yunus, GAO Xin, WU Jing. Study on factors influencing gut microbiota α diversity in the older people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1433-1437. doi: 10.16462/j.cnki.zhjbkz.2022.12.012

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Study on factors influencing gut microbiota α diversity in the older people

doi: 10.16462/j.cnki.zhjbkz.2022.12.012

1.
Division of non-communicable diseases and elderly health management, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2.
Capital Medical University, Beijing 100069, China
3.
Yuanbao Center for Disease Control and Prevention, Dandong 118001, China
4.
Korla Center for Disease Control and Prevention, Korla 841004, China

Funds:

Operation of the Public Health Emergency Response Mechanism-NCD Prevention and Control Program 131031001000210001

National Key R & D Program of China 2020YFC2003000

More Information

Corresponding author: YIN Zhao-xue, E-mail: yinzx@chinacdc.cn; WU Jing, E-mail: wujing@chinacdc.cn
Received Date: 2021-11-15
Rev Recd Date: 2022-06-28

Available Online: 2022-12-30

Publish Date: 2022-12-10

Abstract

Abstract

Objective To explore factors influencing α diversity of gut micro-biota in the older people. Methods Stool samples were collected to extract gut microbiota DNA, 16Sr-DNA sequencing was conducted, and gut microbiota α diversity was analyzed. α diversity was categorized as 'High' or 'Low' according to the quantile of every indicator. Logistic regression models were run to analyze the potential factors that influencing gut microbiota diversity. Results Multivariate logistic regressions showed, compared with the lowest tertile group, OR(95% CI) of high Shannon index in the higher tertile group of refined grain and fruit intake was 0.57(0.37-0.88) and 2.03(1.27-3.24), respectively. Compared with the low group, the possibility of high Shannon index in the high group of pickle intake frequency declined, with OR of 0.45(0.26-0.78). Similarly with Shannon index, refined grain, pickles intake frequency, and fruit intake were all factors influencing the Simpson's index, as well as sex (P=0.028). Conclusions Increasing fruit intake may be beneficial for α diversity of gut microbiota, while intake of refined grain and pickles may be harmful in the older people.
- Gut microbiota,
- α diversity,
- Influencing factors,
- Older people

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References(10)

References

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