Association between maternal iron nutrition during pregnancy and congenital heart disease in offspring based on a case-control study

YAN Ming-xin; ZHAO Dou-dou; PEI Lei-lei; ZHANG Ruo; QU Peng-fei; DANG Shao-nong

doi:10.16462/j.cnki.zhjbkz.2022.12.013

Volume 26 Issue 12

Dec. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(12): 1438-1444

YAN Ming-xin, ZHAO Dou-dou, PEI Lei-lei, ZHANG Ruo, QU Peng-fei, DANG Shao-nong. Association between maternal iron nutrition during pregnancy and congenital heart disease in offspring based on a case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1438-1444. doi: 10.16462/j.cnki.zhjbkz.2022.12.013

Citation:

YAN Ming-xin, ZHAO Dou-dou, PEI Lei-lei, ZHANG Ruo, QU Peng-fei, DANG Shao-nong. Association between maternal iron nutrition during pregnancy and congenital heart disease in offspring based on a case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1438-1444. doi: 10.16462/j.cnki.zhjbkz.2022.12.013

Citation:

YAN Ming-xin, ZHAO Dou-dou, PEI Lei-lei, ZHANG Ruo, QU Peng-fei, DANG Shao-nong. Association between maternal iron nutrition during pregnancy and congenital heart disease in offspring based on a case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1438-1444. doi: 10.16462/j.cnki.zhjbkz.2022.12.013

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Association between maternal iron nutrition during pregnancy and congenital heart disease in offspring based on a case-control study

doi: 10.16462/j.cnki.zhjbkz.2022.12.013

YAN Ming-xin¹,
ZHAO Dou-dou^{2, 3},
PEI Lei-lei¹,
ZHANG Ruo¹,
QU Peng-fei^{2, 3
,
,},
DANG Shao-nong^{1
,
,}

1.
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China
2.
Translational Medicine Center Northwest Women's and Children's Hospital, Xi'an 710061, China
3.
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China

Funds:

National Natural Science Foundation of China 82103924

National Natural Science Foundation of China 72174167

The Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning Sxwsjswzfcght2016-013

National Key Research and Development Program of China 2017YFC0907200

National Key Research and Development Program of China 2017YFC0907201

More Information

Corresponding author: QU Peng-fei, E-mail: xinxi3057@163.com; DANG Shao-nong, E-mail: tjdshn@mail.xjtu.edu.cn
Received Date: 2021-12-01
Rev Recd Date: 2022-03-09

Available Online: 2022-12-30

Publish Date: 2022-12-10

Abstract

Abstract

Objective The study aims to explore the relationship between maternal iron nutrition during pregnancy and congenital heart disease (CHD) in offspring. Methods A matched case-control study was conducted in Shaanxi Province from January 2014 to December 2016, and a food frequency questionnaire was used to collect dietary nutrition during pregnancy among women. The conditional logistic regression model was adopted to examine the association between maternal iron nutrition during pregnancy and CHD and its subtypes in offsprings, and subgroup analysis was further performed to test results stability. Results After adjusting for confounding factors, maternal iron supplementation during pregnancy reduced the risk for CHD in offsprings (< 30 days: OR=0.54, 95% CI: 0.37-0.79; ≥ 30 days: OR=0.25, 95% CI: 0.16-0.38). Higher dietary iron intake during pregnancy (≥29mg/d) reduced the risk for CHD in offsprings (OR=0.69, 95% CI: 0.54-0.88). The subgroup analysis showed that the relationship between maternal iron nutrition during pregnancy and CHD was stable. In addition, the risk of ventricular septal defect (VSD), atrial septal defect (ASD), patent ductus arteriosus (PDA), and tetralogy of fallot (TOF) in the offspring was lower among mothers with iron supplementation ≥30 days during pregnancy. If the mothers supplemented iron less than 30 days, the risk for ASD in the offspring would reduce. The risk of VSD and PDA in the offspring was lower among mothers with a higher dietary iron intake during pregnancy (≥29mg/d). Conclusions The higher iron nutrition level of mothers during pregnancy is associated with the reduced risk for CHD in offspring. Pregnant women should ensure adequate iron intake during pregnancy to promote the health of mothers and babies.
- Iron nutrition,
- Congenital heart disease,
- Pregnancy,
- Case-control study

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References(21)

References

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