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CN 34-1304/RISSN 1674-3679

XU Hong-bing, LIU Ling-yan, WANG Yang, HE Xing-hou, YI Tie-ci, ZHU Yu-tong, LIU Sheng-cong, CHEN Jie, GUAN Xin-peng, WANG Tong, ZHANG Yi, WU Rong-shan, ZHAO Qian, SONG Xiao-ming, LI Jian-ping, HUANG Wei. Impacts of ambient particles of differential sizes and sourceson arrhythmias in adults[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 41-46. doi: 10.16462/j.cnki.zhjbkz.2023.01.008
Citation: XU Hong-bing, LIU Ling-yan, WANG Yang, HE Xing-hou, YI Tie-ci, ZHU Yu-tong, LIU Sheng-cong, CHEN Jie, GUAN Xin-peng, WANG Tong, ZHANG Yi, WU Rong-shan, ZHAO Qian, SONG Xiao-ming, LI Jian-ping, HUANG Wei. Impacts of ambient particles of differential sizes and sourceson arrhythmias in adults[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 41-46. doi: 10.16462/j.cnki.zhjbkz.2023.01.008

Impacts of ambient particles of differential sizes and sourceson arrhythmias in adults

doi: 10.16462/j.cnki.zhjbkz.2023.01.008
Funds:

China Postdoctoral Science Foundation 2021M690249

The Peking University Health Science Center-University of Michigan Health System Joint Institute for Clinical and Translational Research BMU20140467

More Information
  • Corresponding author: HUANG Wei, E-mail: whuang@bjmu.edu.cn
  • Received Date: 2022-03-01
  • Rev Recd Date: 2022-04-21
  • Available Online: 2023-02-09
  • Publish Date: 2023-01-10
  •   Objective  To assess the impacts of ambient particles of differential sizes and sources on arrhythmias in adults.  Methods  A total of 73 healthy adults underwent 4 repeated clinical visits between November 2014 and January 2016. At each visit, 24h-ambulatory electrocardiograms were performed to record hourly arrhythmia episodes; And serum inflammatory biomarkers, including soluble IL-1 receptor antagonist and macrophage inflammatory protein-1β were also measured. Concentrations of ambient fine particles and particles in size fractions of 5.6-560.0 nm were monitored throughout the study period. Generalized estimating equation models were conducted to evaluate the impacts of ambient particles on arrhythmias.  Results  Episodes of premature ventricular contraction, ventricular couplets, supraventricular premature beat, and ventricular tachycardia were positively associated with interquartile range increases in ultrafine particles at prior 1-day moving average of exposure (P < 0.05), with relative risks of 1.89 (95% CI: 1.27-2.51), 2.23 (95% CI: 1.45-3.00), 1.44 (95% CI: 1.12-1.77), and 2.63 (95% CI: 1.42-3.83), respectively. Particles originated from secondary aerosols and aged vehicle emissions were also associated with arrhythmia episodes. Stratified analyses showed stronger associations in participants with higher levels of soluble IL-1 receptor antagonist and macrophage inflammatory protein-1β.  Conclusions  Ambient particles, especially particles from traffic emission were capable of increasing risks of arrhythmia episodes in adults, and participants with higher levels of systemic inflammation were prone to the proarrhythmic effects of particles.
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