The association of sleep duration with non-alcoholic fatty liver disease

OU Xia-xian; LI Min-tao; LYU Jun; SUN Dian-jian-yi; MA yuan; MAN Sai-li-mai; YIN Jian-chun; WANG Bo; YU Can-qing; LI Li-ming

doi:10.16462/j.cnki.zhjbkz.2023.01.009

Volume 27 Issue 1

Jan. 2023

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2023 > 27(1): 47-52

OU Xia-xian, LI Min-tao, LYU Jun, SUN Dian-jian-yi, MA yuan, MAN Sai-li-mai, YIN Jian-chun, WANG Bo, YU Can-qing, LI Li-ming. The association of sleep duration with non-alcoholic fatty liver disease[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 47-52. doi: 10.16462/j.cnki.zhjbkz.2023.01.009

Citation:

OU Xia-xian, LI Min-tao, LYU Jun, SUN Dian-jian-yi, MA yuan, MAN Sai-li-mai, YIN Jian-chun, WANG Bo, YU Can-qing, LI Li-ming. The association of sleep duration with non-alcoholic fatty liver disease[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 47-52. doi: 10.16462/j.cnki.zhjbkz.2023.01.009

Citation:

OU Xia-xian, LI Min-tao, LYU Jun, SUN Dian-jian-yi, MA yuan, MAN Sai-li-mai, YIN Jian-chun, WANG Bo, YU Can-qing, LI Li-ming. The association of sleep duration with non-alcoholic fatty liver disease[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 47-52. doi: 10.16462/j.cnki.zhjbkz.2023.01.009

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The association of sleep duration with non-alcoholic fatty liver disease

doi: 10.16462/j.cnki.zhjbkz.2023.01.009

OU Xia-xian¹,
LI Min-tao¹,
LYU Jun^{1, 4, 5},
SUN Dian-jian-yi^{1, 4},
MA yuan²,
MAN Sai-li-mai^{1, 4},
YIN Jian-chun³,
WANG Bo^{4
,
,},
YU Can-qing^{1, 4, 5
,
,},
LI Li-ming^{1, 4, 5}

1.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
2.
Meinian Institute of Health, Beijing 100191, China
3.
MJ Health Screening Center, Beijing 100006, China
4.
Meinian Institute of Health, Peking University Health Science Center, Beijing 100191, China
5.
Center for Public Health and Major Epidemic Prevention and Control, Peking University, Beijing 100191, China

Funds:

National Natural Science Foundation of China 91846303

National Natural Science Foundation of China 81941018

More Information

Corresponding author: WANG Bo, E-mail: paul@meinianresearch.com; YU Can-qing, E-mail: yucanqing@pku.edu.cn
Received Date: 2022-01-28
Rev Recd Date: 2022-06-13

Available Online: 2023-02-09

Publish Date: 2023-01-10

Abstract

Abstract

Objective To explore the association of sleep duration with non-alcoholic fatty liver disease (NAFLD) among a health checkup population aged 18 years or older in urban District of Beijing from 2008 to 2018. Methods A cross-sectional study was designed based on the health checkup data from 2008 to 2018 at Beijing MJ Health Screening Center. Multinomial logistic regression was used to explore the association of sleep duration with NAFLD, and further to assess the associations across different subgroups according to related covariates. Results Among 77 697 participants, the average age was (40.7±11.7) years. Of 12.7% reported a sleep duration of fewer than six hours, and 7.0% reported eight hours and more, respectively. The detection rate of NAFLD by ultrasound scan was 37.6%. After adjusting for the potential confounders, the odds ratio (95% CI) for NAFLD for short sleep duration and long sleep duration compared to the reference(normal sleep duration) were 1.08 (95% CI: 1.03-1.14, P=0.003) and 0.88 (95% CI: 0.82-0.95, P < 0.001), respectively. The association of short sleep duration with NAFLD was more substantial in males (P_interaction < 0.05) and individuals aged 18 to 29 and 30 to 39 years old (P_interaction < 0.001). However, the association was no longer significant (P > 0.05) when further adjusting BMI. Conclusions Sleep duration is associated with the risk of NAFLD, especially in males and young adults. Meanwhile, BMI played a vital role in the association between sleep duration and NAFLD.
- Sleep duration,
- Non-alcoholic fatty liver disease,
- Cross-sectional studies,
- BMI

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References(25)

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