Relationship between hemoglobin level in early pregnancy and gestational diabetes mellitus: a birth cohort study

YAN Ming-xin; ZHAO Dou-dou; WAN Hui-ling; ZHAO Huan; SHAN Li; PEI Lei-lei; MI Yang; QU Peng-fei

doi:10.16462/j.cnki.zhjbkz.2023.01.011

Volume 27 Issue 1

Jan. 2023

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YAN Ming-xin, ZHAO Dou-dou, WAN Hui-ling, ZHAO Huan, SHAN Li, PEI Lei-lei, MI Yang, QU Peng-fei. Relationship between hemoglobin level in early pregnancy and gestational diabetes mellitus: a birth cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 60-64. doi: 10.16462/j.cnki.zhjbkz.2023.01.011

Citation:

YAN Ming-xin, ZHAO Dou-dou, WAN Hui-ling, ZHAO Huan, SHAN Li, PEI Lei-lei, MI Yang, QU Peng-fei. Relationship between hemoglobin level in early pregnancy and gestational diabetes mellitus: a birth cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 60-64. doi: 10.16462/j.cnki.zhjbkz.2023.01.011

Citation:

YAN Ming-xin, ZHAO Dou-dou, WAN Hui-ling, ZHAO Huan, SHAN Li, PEI Lei-lei, MI Yang, QU Peng-fei. Relationship between hemoglobin level in early pregnancy and gestational diabetes mellitus: a birth cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 60-64. doi: 10.16462/j.cnki.zhjbkz.2023.01.011

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Relationship between hemoglobin level in early pregnancy and gestational diabetes mellitus: a birth cohort study

doi: 10.16462/j.cnki.zhjbkz.2023.01.011

YAN Ming-xin^{1, 2},
ZHAO Dou-dou^{1, 2},
WAN Hui-ling¹,
ZHAO Huan¹,
SHAN Li¹,
PEI Lei-lei²,
MI Yang¹,
QU Peng-fei^{1, 2
,
,}

1.
Northwest Women and Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an 710061, China
2.
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China

Funds:

the National Key R & D Program of China 2016YFC1000101

National Natural Science Foundation of China 82103924

National Natural Science Foundation of China 72174167

Xi'an Science and Technology Plan Project 20YXYJ0005(8)

More Information

Corresponding author: QU Peng-fei, E-mail: xinxi3057@163.com
Received Date: 2022-03-30
Rev Recd Date: 2022-06-29

Available Online: 2023-02-09

Publish Date: 2023-01-10

Abstract

Abstract

Objective To investigate the relationship between hemoglobin levels in early pregnancy and gestational diabetes mellitus (GDM) in pregnant women in northwest China. Methods In Northwest Women's and Children's Hospital from July 2018 to July 2019, women in early pregnancy were recruited to birth cohort. A questionnaire was used to collect their basic demographic characteristics and lifestyle behaviors, and to follow up the hemoglobin levels and oral glucose tolerance test (OGTT) in early pregnancy. The association of hemoglobin levels in early pregnancy with GDM was first explored using a logistic regression model, and the nonlinear relationship between hemoglobin levels and GDM was further investigated by restricted cubic splines. Results After adjusting for confounders, high hemoglobin levels (Hb ≥135 g/L) in early pregnancy increased the risk of GDM (OR=1.44, 95% CI: 1.13-1.83). For every 10g/L increase in hemoglobin levels in early pregnancy, FPG, OGTT 1h glucose, and OGTT 2h glucose levels increased by 0.03 mmol/L (95% CI: 0.01-0.05), 0.14 mmol/L (95% CI: 0.07-0.21), and 0.13 mmol/L (95% CI: 0.08-0.19), respectively. The results of the restricted cubic strip showed that the risk of GDM progressively increased with increasing hemoglobin levels in early pregnancy. Conclusions Elevated hemoglobin levels in early pregnancy will increase the risk of GDM. Women hemoglobin levels in early pregnancy should be actively monitored to promote maternal and infant health.
- Gestational diabetes mellitus,
- Early Pregnancy,
- Haemoglobin levels,
- Oral glucose tolerance test

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References(22)

References

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