Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people

YANG Pei; ZHANG Yu-jie; ZHONG Wen-fang; WANG Xiao-meng; LYU Yue-bin; MAO Chen

doi:10.16462/j.cnki.zhjbkz.2023.01.014

Volume 27 Issue 1

Jan. 2023

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YANG Pei, ZHANG Yu-jie, ZHONG Wen-fang, WANG Xiao-meng, LYU Yue-bin, MAO Chen. Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 77-81. doi: 10.16462/j.cnki.zhjbkz.2023.01.014

Citation:

YANG Pei, ZHANG Yu-jie, ZHONG Wen-fang, WANG Xiao-meng, LYU Yue-bin, MAO Chen. Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 77-81. doi: 10.16462/j.cnki.zhjbkz.2023.01.014

Citation:

YANG Pei, ZHANG Yu-jie, ZHONG Wen-fang, WANG Xiao-meng, LYU Yue-bin, MAO Chen. Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 77-81. doi: 10.16462/j.cnki.zhjbkz.2023.01.014

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Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people

doi: 10.16462/j.cnki.zhjbkz.2023.01.014

1.
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
2.
National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China

YANG Pei and ZHANG Yu-jie contributed equally to the work

Funds:

National Natural Science Foundation of China 82173588

National Natural Science Foundation of China 81973109

National Natural Science Foundation of China 82001476

More Information

Corresponding author: MAO Chen, E-mail: maochen9@smu.edu.cn
Received Date: 2022-03-24
Rev Recd Date: 2022-06-19

Available Online: 2023-02-09

Publish Date: 2023-01-10

Abstract

Abstract

Objective To explore the associations between the single nucleotide polymorphism (SNP) of histone deacetylase 9 (HDAC9) and calcineurin catalytic subunit A (PPP3CA) and frailty in the Chinese elderly people. Methods Our study included 665 participants in the frailty group and 3 388 participants in the control group. Associations between rs2074633 and rs17030795 gene polymorphisms and frailty were evaluated based on genotype frequencies, and five genetic models (co-dominance, additive, dominance, recessive and over-dominance models). Results In co-dominance model, individuals carrying HDAC9 rs2074633 TC genotype (OR=1.99, 95% CI: 1.36-2.90) and CC genotype (OR=2.15, 95% CI: 1.48-3.13) were more likely to develop frailty, compared with those carrying TT genotype3. The rs2074633 polymorphisms increased the risk of frailty in both additive model (OR=1.28, 95% CI: 1.11-1.47), dominant model (OR=2.07, 95% CI: 1.44-2.98) and recessive model (OR=1.21, 95% CI: 1.01-1.45). In co-dominance model, individuals carrying PPP3CA rs17030795 AG (OR=1.72, 95% CI: 1.19-2.51) genotype and GG (OR=1.98, 95% CI: 1.37-2.87) genotype were more likely to develop frailty, compared with those carrying AA genotype. The rs17030795 polymorphisms increased the risk of frailty in both additive model (OR=1.28, 95% CI: 1.11-1.48), dominant model (OR=1.85, 95% CI: 1.29-2.66) and recessive model (OR=1.25, 95% CI: 1.04-1.50). Conclusions The rs2074633and rs17030795 polymorphisms are associated with the increased risk of frailty.
- Frailty,
- Gene polymorphism,
- Histone deacetylase 9,
- Calcineurin catalytic subunit A

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References(26)

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