Transmission modes and influencing factors of Streptococcus pneumoniae among preschool children in Foshan

YU Hai-feng; DENG Wen-jun; LI Ping-yuan; ZHANG Jing-feng; ZHOU Jun-li; YAO Zhen-jiang; YE Xiao-hua

doi:10.16462/j.cnki.zhjbkz.2023.02.010

Volume 27 Issue 2

Feb. 2023

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2023 > 27(2): 184-190

YU Hai-feng, DENG Wen-jun, LI Ping-yuan, ZHANG Jing-feng, ZHOU Jun-li, YAO Zhen-jiang, YE Xiao-hua. Transmission modes and influencing factors of Streptococcus pneumoniae among preschool children in Foshan[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(2): 184-190. doi: 10.16462/j.cnki.zhjbkz.2023.02.010

Citation:

YU Hai-feng, DENG Wen-jun, LI Ping-yuan, ZHANG Jing-feng, ZHOU Jun-li, YAO Zhen-jiang, YE Xiao-hua. Transmission modes and influencing factors of Streptococcus pneumoniae among preschool children in Foshan[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(2): 184-190. doi: 10.16462/j.cnki.zhjbkz.2023.02.010

Citation:

YU Hai-feng, DENG Wen-jun, LI Ping-yuan, ZHANG Jing-feng, ZHOU Jun-li, YAO Zhen-jiang, YE Xiao-hua. Transmission modes and influencing factors of Streptococcus pneumoniae among preschool children in Foshan[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(2): 184-190. doi: 10.16462/j.cnki.zhjbkz.2023.02.010

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Transmission modes and influencing factors of Streptococcus pneumoniae among preschool children in Foshan

doi: 10.16462/j.cnki.zhjbkz.2023.02.010

1.
Medical Examination Department, Leliu Hospital Affiliated to Shunde Hospital, Guangzhou University of Traditional Chinese Medicine, Foshan 528300, China
2.
Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China

Funds:

National Natural Science Foundation of China 81973069

Guangdong Basic and Applied Basic Research Foundation 2019A1515010915

More Information

Corresponding author: YE Xiao-hua, E-mail: smalltomato@163.com
Received Date: 2022-07-10
Rev Recd Date: 2022-10-06

Available Online: 2023-02-20

Publish Date: 2023-02-10

Abstract

Abstract

Objective To urderstand the transmission mode and influencing factors of Streptococcus pneumoniae (S. pneumoniae) in preschool children, and to provide an important scientific basis for revealing the transmission pattern and controlling the transmission. Methods Stratified cluster sampling method was used to select 2 031 healthy children from seven kindergartens in Shunde District, Foshan City. Nasal swabs were taken and tested for S. pneumoniae. The random-effect model was used to explore the clustering of S. pneumoniae carriage in children, and homology analysis of molecular types was used to reveal the transmission mode. Both χ² test and random-effect logistic regression were used to analyze the effects of multiple influencing factors. Results The nasal carriage rate of S. pneumoniae in children was 21.8%. Random-effect model indicated that there was a class-level clustering effect of S. pneumoniae carriage in children (Z=4.34, P < 0.001). The within-class homology rates of strains in seven kindergartens were 60.9%, 79.2%, 76.0%, 80.0%, 82.8%, 75.9% and 33.3%, respectively. The between-class homology rates were 90.6%, 91.7%, 88.0%, 82.9%, 63.8%, 93.1% and 76.2%, respectively. The analysis of influencing factors showed that non-household registration (OR=1.36, 95% CI: 1.04-1.79, P=0.027), rural area (OR=1.60, 95% CI: 1.09-2.35, P=0.017) and nasal carrying Moraxella catarrhalis (OR=1.91, 95% CI: 1.49-2.45, P < 0.001) were risk factors for S. pneumoniae carriage, while grade (OR=0.66, 95% CI: 0.52-0.83, P < 0.001) and nasal Staphylococcus aureus carriage (OR=0.41, 95% CI: 0.31-0.55, P < 0.001) were protective factors. Conclusions There is a high risk of S. pneumoniae transmission among children within and between classes. Grade, household registration, area and nasal carriage of other bacteria are important influencing factors for S. pneumoniae carriage in preschool children.
- Streptococcus pneumoniae,
- Clustering,
- Influencing factors,
- Children

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References(14)

References

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