Prevalence and influencing factors of multi-drug resistance among 1 536 tuberculosis patients in Lanzhou City

ZHANG Yuqi; WANG Zhiyong; LI Zongyu; GAO Wenlong; LI Ming; LUO Qiuxia; XIANG Yuanyuan; BAO Kai

doi:10.16462/j.cnki.zhjbkz.2023.07.019

Volume 27 Issue 7

Jul. 2023

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ZHANG Yuqi, WANG Zhiyong, LI Zongyu, GAO Wenlong, LI Ming, LUO Qiuxia, XIANG Yuanyuan, BAO Kai. Prevalence and influencing factors of multi-drug resistance among 1 536 tuberculosis patients in Lanzhou City[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(7): 854-857. doi: 10.16462/j.cnki.zhjbkz.2023.07.019

Citation:

ZHANG Yuqi, WANG Zhiyong, LI Zongyu, GAO Wenlong, LI Ming, LUO Qiuxia, XIANG Yuanyuan, BAO Kai. Prevalence and influencing factors of multi-drug resistance among 1 536 tuberculosis patients in Lanzhou City[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(7): 854-857. doi: 10.16462/j.cnki.zhjbkz.2023.07.019

Citation:

ZHANG Yuqi, WANG Zhiyong, LI Zongyu, GAO Wenlong, LI Ming, LUO Qiuxia, XIANG Yuanyuan, BAO Kai. Prevalence and influencing factors of multi-drug resistance among 1 536 tuberculosis patients in Lanzhou City[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(7): 854-857. doi: 10.16462/j.cnki.zhjbkz.2023.07.019

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Prevalence and influencing factors of multi-drug resistance among 1 536 tuberculosis patients in Lanzhou City

doi: 10.16462/j.cnki.zhjbkz.2023.07.019

1.
Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
2.
Lanzhou Pulmonary Hospital, Lanzhou 730030, China

ZHANG Yuqi and WANG Zhiyong contributed equally to this article

Funds:

Innovation and Enterprising Talents of Lanzhou 2020-RC-76

More Information

Corresponding author: GAO Wenlong, E-mail: gaowl06@aliyun.com
Received Date: 2022-04-20
Rev Recd Date: 2022-08-02

Available Online: 2023-08-08

Publish Date: 2023-07-10

Abstract

Abstract

Objective The goal of this research was to investigate the prevalence of multi-drug resistance and its influencing factors in 1 536 tuberculosis patients. Methods A total of 1 536 confirmed tuberculosis patients were recruited in Lanzhou from 2018 to 2020, using the Tuberculosis Management Information System. Chi-square test and multivariate logistic regression analysis were used to explore the influencing factors of multi-drug resistance. Results Among the 1 536 tuberculosis patients, there were 445 (29.0%) cases presented with drug-resistant tuberculosis and 327 (21.3%) cases with multidrug-resistant tuberculosis. The results of univariate analysis showed that there were significant differences in multidrug-resistant status among patients with different genders, ages, nationalities, occupations, household registration types, and registered classifications. Multivariate logistic regression analysis showed that those working as farmers, herdsmen, workers (OR=2.95, 95% CI: 1.32-6.59, P=0.008) and other occupations (OR=3.12, 95% CI: 1.41-6.88, P=0.005), as well as patients classified as relapse (OR=6.16, 95% CI: 3.66-10.39, P < 0.001), retreatment failure (OR=11.93, 95% CI: 4.61-30.88, P < 0.001) and initial treatment failure (OR=14.10, 95% CI: 7.74-25.69, P < 0.001) were more likely to develop multi-drug resistance. Converserly, patients registered as residing in Lanzhou were less likely to develop multi-drug resistance (OR=0.11, 95% CI: 0.08-0.16, P < 0.001). Conclusions The prevalence of MDR in tuberculosis patients in Lanzhou was found to be high. Occupations such as farmers, herdsmen, and workers, along with other occupations, non-Lanzhou household registration, and classifications of relapse, initial treatment failure, and retreatment failure were identified as major risk factors for developing MDR.
- Tuberculosis,
- Multidrug-resistant tuberculosis,
- Logistic regression analysis model,
- Influencing factors

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References(7)

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