Correlation between serum 25(OH)D<sub>3</sub> levels and alcoholic fatty liver disease in adult males in Hefei

WANG Xiaoyu; WANG Huihui; ZENG Li; GONG Weiyi; YANG Bingbing; XU Dexiang; HU Chunqiu

doi:10.16462/j.cnki.zhjbkz.2023.08.010

Volume 27 Issue 8

Aug. 2023

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WANG Xiaoyu, WANG Huihui, ZENG Li, GONG Weiyi, YANG Bingbing, XU Dexiang, HU Chunqiu. Correlation between serum 25(OH)D3 levels and alcoholic fatty liver disease in adult males in Hefei[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(8): 928-932. doi: 10.16462/j.cnki.zhjbkz.2023.08.010

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WANG Xiaoyu, WANG Huihui, ZENG Li, GONG Weiyi, YANG Bingbing, XU Dexiang, HU Chunqiu. Correlation between serum 25(OH)D₃ levels and alcoholic fatty liver disease in adult males in Hefei[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(8): 928-932. doi: 10.16462/j.cnki.zhjbkz.2023.08.010

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Correlation between serum 25(OH)D₃ levels and alcoholic fatty liver disease in adult males in Hefei

doi: 10.16462/j.cnki.zhjbkz.2023.08.010

1.
School of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical University, Hefei 230032, China
2.
Gastroenterology Department of the Fourth Hospital of Anhui Medical University, Hefei 230032, China
3.
School of Public Health, Department of Health Toxicology, Anhui Medical University, Hefei 230032, China

Funds:

National Natural Science Foundation of China 81402676

Natural Research Project of Higher Education of Anhui Provence 2022AH040094

Received Date: 2022-11-08
Rev Recd Date: 2023-01-15

Available Online: 2023-09-02

Publish Date: 2023-08-10

Abstract

Abstract

Objective To explore the correlation between 25-hydroxy vitamin D₃ [25(OH)D₃] level and alcoholic fatty liver disease (AFLD) of adult males in Hefei. Methods A total of 90 patients with AFLD and 90 healthy controls were collected according to the inclusion criteria. General information of study subjects were collected through questionnaires, electronic medical records were consulted and clinical examination data were collected. Serum 25(OH)D₃ levels were detected by radioimmunoassay. The correlation between serum 25(OH)D₃ levels and AFLD was analyzed by logistic regression model. Results Mann-Whitney U test showed that serum 25(OH)D₃ [49.15(39.08, 71.09)] in patients with AFLD were significantly lower than the control group [67.04(51.03, 76.84)] (Z=-4.088, P < 0.001). Trending χ² test showed that the prevalence of AFLD increases with increasing 25(OH)D₃ levels (χ² _trend=13.13, P < 0.001). Mann-Whitney U test showed that the level of 25(OH)D₃ [38.46(30.22, 42.41)] in the moderate to severe AFLD group was significantly lower than that in the mild AFLD group [52.70(42.41, 73.13)], and the difference was statistically significant (Z=-3.172, P=0.001). The logistic regression analysis showed that men with insufficient and adequate serum 25(OH)D₃ had a reduced risk of AFLD when compared with men with serum 25(OH)D₃ deficiency after adjusting for confounders (OR=0.085, OR=0.827). Conclusion The serum 25(OH)D₃ level of adult men in Hefei was associated with the risk and severity of AFLD.
- 25(OH)D₃ level,
- Alcoholic fatty liver disease,
- Adult males,
- Relevance

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References(18)

References

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