The correlation analysis between the fibrinogen-albumin ratio and renal damage and disease activity of systemic lupus erythematosus

ZHANG Xiangxiang; PAN Haifeng; WANG Deguang

doi:10.16462/j.cnki.zhjbkz.2023.08.011

Volume 27 Issue 8

Aug. 2023

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ZHANG Xiangxiang, PAN Haifeng, WANG Deguang. The correlation analysis between the fibrinogen-albumin ratio and renal damage and disease activity of systemic lupus erythematosus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(8): 933-939. doi: 10.16462/j.cnki.zhjbkz.2023.08.011

Citation:

ZHANG Xiangxiang, PAN Haifeng, WANG Deguang. The correlation analysis between the fibrinogen-albumin ratio and renal damage and disease activity of systemic lupus erythematosus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(8): 933-939. doi: 10.16462/j.cnki.zhjbkz.2023.08.011

Citation:

ZHANG Xiangxiang, PAN Haifeng, WANG Deguang. The correlation analysis between the fibrinogen-albumin ratio and renal damage and disease activity of systemic lupus erythematosus[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(8): 933-939. doi: 10.16462/j.cnki.zhjbkz.2023.08.011

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The correlation analysis between the fibrinogen-albumin ratio and renal damage and disease activity of systemic lupus erythematosus

doi: 10.16462/j.cnki.zhjbkz.2023.08.011

1.
Department of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
2.
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, China

Funds:

Natural Science Foundation of Anhui Province 2008085MH244

Incubation Program of National Natural Science Foundation of China of The Second Hospital of Anhui Medical University 2020GMFY04

Co-construction Project of Clinical and Preliminary Disciplines of Anhui Medical University in 2020 2020lcxk022

More Information

Corresponding author: WANG Deguang, E-mail: wangdeguang@ahmu.edu.cn
Received Date: 2022-06-07
Rev Recd Date: 2022-09-25

Available Online: 2023-09-02

Publish Date: 2023-08-10

Abstract

Abstract

Objective To explore the relationship between the fibrinogen-albumin ratio (FAR) and renal damage and disease activity in newly diagnosed patients with systemic lupus erythematosus (SLE). Methods The medical records of relevant clinical data of 156 newly diagnosed SLE patients and 159 healthy controls were retrospectively analyzed. Results The FAR of SLE patients was significantly higher than that of healthy controls (Z=-10.390, P < 0.001). The FAR of SLE patients in the moderate and severe disease activity group was higher than that in the mild disease activity group (Z=-4.703, P < 0.001). The FAR in lupus nephritis group was significantly higher than that in non-lupus nephritis group (Z=-6.312, P < 0.001). The FAR of SLE patients was negatively correlated with complement 3 (r=-0.249, P=0.002), serum total protein (r=-0.474, P < 0.001), and positively correlated with erythrocyte sedimentation rete (r=0.383, P < 0.001), C-reactive protein (r=0.293, P < 0.001), blood urea nitrogen (r=0.220, P=0.006), uric acid (r=0.296, P < 0.001), creatinine (r=0.180, P=0.025), 24-hour urine protein (r=0.588, P < 0.001) and SLE disease activity index (r=0.430, P < 0.001). Multivariate logistic regression analysis showed that FAR was an independent risk factor for moderate to severe SLE activity and renal damage. According to receiver operating characteristic curve, the areas under the curve of FAR for diagnosis of SLE, prediction of moderate to severe SLE activity and renal damage were 0.84(95% CI: 0.79-0.88), 0.72(95% CI: 0.64-0.80), 0.80(95% CI: 0.72-0.87), respectively. Conclusions FAR is associated with disease activity and renal damage in SLE patients, and has certain clinical significance for assessing SLE disease activity and renal damage.
- Fibrinogen-albumin ratio,
- Systemic lupus erythematosus,
- Lupus nephritis,
- Disease activity

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References(17)

References

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