A nested case-control study on the influencing factors of sudden cardiac death

ZHANG Lizhen; YIN Chun; LI Siyu; WU Xijiang; CHEN Yarong; SHEN Shujuan; WANG Zhongge; CHEN Ruirui; LI Jing; XU Lulu; HU Yujia; BAI Yana

doi:10.16462/j.cnki.zhjbkz.2023.10.007

Volume 27 Issue 10

Oct. 2023

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ZHANG Lizhen, YIN Chun, LI Siyu, WU Xijiang, CHEN Yarong, SHEN Shujuan, WANG Zhongge, CHEN Ruirui, LI Jing, XU Lulu, HU Yujia, BAI Yana. A nested case-control study on the influencing factors of sudden cardiac death[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1153-1160. doi: 10.16462/j.cnki.zhjbkz.2023.10.007

Citation:

ZHANG Lizhen, YIN Chun, LI Siyu, WU Xijiang, CHEN Yarong, SHEN Shujuan, WANG Zhongge, CHEN Ruirui, LI Jing, XU Lulu, HU Yujia, BAI Yana. A nested case-control study on the influencing factors of sudden cardiac death[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1153-1160. doi: 10.16462/j.cnki.zhjbkz.2023.10.007

Citation:

ZHANG Lizhen, YIN Chun, LI Siyu, WU Xijiang, CHEN Yarong, SHEN Shujuan, WANG Zhongge, CHEN Ruirui, LI Jing, XU Lulu, HU Yujia, BAI Yana. A nested case-control study on the influencing factors of sudden cardiac death[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1153-1160. doi: 10.16462/j.cnki.zhjbkz.2023.10.007

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A nested case-control study on the influencing factors of sudden cardiac death

doi: 10.16462/j.cnki.zhjbkz.2023.10.007

1.
Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
2.
Workers′ Hospital of Jinchuan Group, Jinchang 737100, China

Funds:

Construction of the Whole-process Management System for Metabolic Diseases Among Staffs in Jinchuan Group Co Ltd Jinkezong2020-02

More Information

Corresponding author: BAI Yana, E-mail: baiyana@lzu.edu.cn
Received Date: 2022-01-09
Rev Recd Date: 2022-06-22

Available Online: 2023-10-23

Publish Date: 2023-10-10

Abstract

Abstract

Objective To study the influencing factors of sudden cardiac death (SCD) based on the cohort population, and to provide basic data for the prevention and etiological research of SCD. Methods A nested case-control study was conducted, involving 52 newly diagnosed cases of SCD during three follow-up visits from 2011 to 2019 in Jinchang cohort. And 208 participants without SCD during the same period of follow-up were selected as the control group according to the matching method of age (±2 years) and 1∶4 individuals of the same sex. Conditional logistic regression model was used to analyze the influencing factors of SCD in Jinchang cohort, and the dose-response relationship of SCD risk was fitted by restricted cubic spline (RCS) models. Results Multivariate conditional logistic regression analysis showed that triglycerides (TG) (OR=2.94, 95% CI: 1.15-7.51), low density lipoprotein cholesterol (LDL-C) (OR=2.70, 95% CI: 1.18-6.22), diabetes (OR=5.59, 95% CI: 1.79-17.46) and abnormal electrocardiogram (OR=5.54, 95% CI: 2.11-14.56) were risk factors for SCD. Education level in high school and above (OR=0.33, 95% CI: 0.12-0.88) was a protective factor for SCD. RCS analysis showed that there was a positive linear dose-response relationship between fasting plasma glucose (FPG), TG and the risk of SCD (general trend P<0.05, non-linear P>0.05). Conclusions TG, LDL-C, diabetes, abnormal electrocardiogram and education level were related to the occurrence of SCD, and there was a dose-response relationship between FPG, TG and the risk of SCD.
- Jinchang cohort,
- Nested case-control study,
- Sudden cardiac death,
- Influencing factors,
- Dose-response relationship

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References(21)

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