Effects of exposure to neonicotinoids on estrogen homeostasis in pregnant women

WANG Yi; WU Linying; XUAN Dongliang; TIAN Jing; WANG Yuanping; YANG Zichen; HAN Minghui; WANG Hexing; PENG Qian; JIANG Qingwu

doi:10.16462/j.cnki.zhjbkz.2023.10.017

Volume 27 Issue 10

Oct. 2023

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WANG Yi, WU Linying, XUAN Dongliang, TIAN Jing, WANG Yuanping, YANG Zichen, HAN Minghui, WANG Hexing, PENG Qian, JIANG Qingwu. Effects of exposure to neonicotinoids on estrogen homeostasis in pregnant women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1228-1233. doi: 10.16462/j.cnki.zhjbkz.2023.10.017

Citation:

WANG Yi, WU Linying, XUAN Dongliang, TIAN Jing, WANG Yuanping, YANG Zichen, HAN Minghui, WANG Hexing, PENG Qian, JIANG Qingwu. Effects of exposure to neonicotinoids on estrogen homeostasis in pregnant women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1228-1233. doi: 10.16462/j.cnki.zhjbkz.2023.10.017

Citation:

WANG Yi, WU Linying, XUAN Dongliang, TIAN Jing, WANG Yuanping, YANG Zichen, HAN Minghui, WANG Hexing, PENG Qian, JIANG Qingwu. Effects of exposure to neonicotinoids on estrogen homeostasis in pregnant women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1228-1233. doi: 10.16462/j.cnki.zhjbkz.2023.10.017

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Effects of exposure to neonicotinoids on estrogen homeostasis in pregnant women

doi: 10.16462/j.cnki.zhjbkz.2023.10.017

1.
Department of Nutrition and Food Hygiene, School of Public Health, Fudan University, Shanghai 200032
2.
China; Physical and Chemical Laboratory, Jiading District for Disease Control and Prevention, Shanghai 201899, China
3.
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China

WANG Yi and WU Linying contributed equally to this article

Funds:

National Natural Science Foundation of China 82273703

More Information

Corresponding author: WANG Hexing, E-mail: wanghexing@fudan.edu.cn; PENG Qian, E-mail: peng59991569@163.com
Received Date: 2023-02-10
Rev Recd Date: 2023-05-20

Available Online: 2023-10-23

Publish Date: 2023-10-10

Abstract

Abstract

Objective To investigate the effect of neonicotinoids (NEOs) on estrogen homeostasis during pregnancy. Methods A total of 151 pregnant women in one administrative district of Shanghai were selected as study participants. A questionnaire survey was used and urine samples were collected. The concentrations of eight NEOs (thiamethoxam, clothianidin, imidacloprid, acetamiprid, thiacloprid, nitenpyram, midaclothiz and dinotefuran), four metabolites (N-desmethyl-thiamethoxam, N-desmethyl-clothianidin, 5-hydroxy-imidacloprid and N-desmethyl-acetamiprid) and three estrogens (estrone, estradiol and estriol) in their urine were determined by ultra-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry. ANOVA and multiple linear regression were used to analyze the effect of NEOs exposure levels on estrogen levels in pregnant women. Results The detection rate of NEOs and their metabolites in urine samples of pregnant women was 93.38%, with a median urinary NEOs concentration of 2.66 μg/g. The acetamiprid and N-desmethyl-acetamiprid had the highest detection rate (78.15%), while the imidacloprid and 5-hydroxy-imidacloprid had the lowest. ANOVA found that higher urinary estrone levels in pregnant women with detectable thiamethoxam and N-desmethyl-thiamethoxam, while lower urinary estradiol and estriol levels in pregnant women with detectable clothianidin and N-desmethyl-clothianidin. Multiple linear regression analysis showed a positive association between urinary all NEOs levels and estrone levels in pregnant women regression coefficient (β=0.137, 95% CI: 0.019-0.256). Urinary thiamethoxam and N-desmethyl-thiamethoxam levels, and urinary acetamiprid and N-desmethyl-acetamiprid levels were positively correlated with estrone levels in pregnant women (β=0.154, 95% CI: 0.032-0.275; β=0.157, 95% CI: 0.028-0.286). Conclusions Pregnant women in Shanghai may be generally exposed to NEOs, and the exposure level of NEOs during pregnancy may affect estrogen homeostasis.
- Pregnant women,
- Neonicotinoid pesticides,
- Estrogen homeostasis,
- Urine,
- Exposed

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References(13)

References

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