Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine

CUI Xiangjie; SHI Li; TAO Yufen

doi:10.16462/j.cnki.zhjbkz.2024.01.015

Volume 28 Issue 1

Jan. 2024

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2024 > 28(1): 96-100

CUI Xiangjie, SHI Li, TAO Yufen. Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 96-100. doi: 10.16462/j.cnki.zhjbkz.2024.01.015

Citation:

CUI Xiangjie, SHI Li, TAO Yufen. Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 96-100. doi: 10.16462/j.cnki.zhjbkz.2024.01.015

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Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine

doi: 10.16462/j.cnki.zhjbkz.2024.01.015

Shi Li Laboratory, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China

Funds:

Major Science and Technology Projects of Yunnan Provincial 202002AA100009

Chinese Academy of Medical Sciences Innovation Fund for Medical Science 2021-I2M-1-004

More Information

Corresponding author: TAO Yufen, E-mail: taoyufen@imbcams.com.cn
Received Date: 2023-06-21
Rev Recd Date: 2023-08-31

Available Online: 2024-02-05

Publish Date: 2024-01-10

Abstract

Abstract

Cervical cancer is one of the common malignancies affecting women worldwide, of which persistent infection with high-risk human papillomavirus (HPV) is the main cause. In the occurrence and development of cervical cancer, in addition to HPV E6, E7 and cervical cancer lesions have a major relationship, some other early proteins such as E2 and E5 also play an essential role. For example, E2 can initiate and maintain viral replication, and E5 can cooperate with E6 and E7 oncoproteins to promote proliferation of infected cells. In this paper, we aim to review the current research progress on the mechanism of HPV E2 and E5 proteins in the development of cervical cancer and the progress of research on E2 and E5 related therapeutic vaccines.
- Cervical cancer,
- Human papillomavirus,
- E2 protein,
- E5 protein,
- Vaccine

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References(29)

References

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