The association between hypertension disorders in pregnancy and the neurodevelopment of infants: a birth cohort study

WANG Xing; WU Wenjing; LIN Qingmei; HAO Yuantao; CAI Li

doi:10.16462/j.cnki.zhjbkz.2024.05.001

Volume 28 Issue 5

May 2024

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WANG Xing, WU Wenjing, LIN Qingmei, HAO Yuantao, CAI Li. The association between hypertension disorders in pregnancy and the neurodevelopment of infants: a birth cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 497-502. doi: 10.16462/j.cnki.zhjbkz.2024.05.001

Citation:

WANG Xing, WU Wenjing, LIN Qingmei, HAO Yuantao, CAI Li. The association between hypertension disorders in pregnancy and the neurodevelopment of infants: a birth cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 497-502. doi: 10.16462/j.cnki.zhjbkz.2024.05.001

Citation:

WANG Xing, WU Wenjing, LIN Qingmei, HAO Yuantao, CAI Li. The association between hypertension disorders in pregnancy and the neurodevelopment of infants: a birth cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 497-502. doi: 10.16462/j.cnki.zhjbkz.2024.05.001

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The association between hypertension disorders in pregnancy and the neurodevelopment of infants: a birth cohort study

doi: 10.16462/j.cnki.zhjbkz.2024.05.001

WANG Xing^{1, 2},
WU Wenjing¹,
LIN Qingmei³,
HAO Yuantao^{4
,
,},
CAI Li^{5
,
,}

1.
Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
2.
Department of Scientific Research and Education, Foshan Women and Children Hospital, Foshan 528000, China
3.
Department of Health Care, Foshan Women and Children Hospital, Foshan 528000, China
4.
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China
5.
Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China

Funds:

Youth Promotion Project of Guangdong Natural Science Foundation 2023A1515030192

Medical Scientific Research Fund Project of Guangdong Province A2024080

More Information

Corresponding author: HAO Yuantao, E-mail: haoyt@bjmu.edu.cn; CAI Li, E-mail: caili5@mail.sysu.edu.cn
Received Date: 2023-10-21
Rev Recd Date: 2024-03-18

Available Online: 2024-06-05

Publish Date: 2024-05-10

Abstract

Abstract

Objective To investigate the association between hypertension disorders in pregnancy (HDP) and the neurodevelopment of infants. Methods The study utilized birth cohort data from the Foshan maternal and child health information system to select a sample of 17 812 pairs of maternals who received antenatal care at a women and children hospital and their offsprings born at the same facility. The neurodevelopment of the infants was assessed using the Neuropsychological Examination Scale for Chinese Children (NESCC) at various intervals throughout the study. Maternals who were exposed to HDP during gestation were categorized as the exposure group, with the control group selected using a 1:1 propensity score matching method. A total of 1 414 pairs of mothers and children were included in the study. The study employed generalized estimation equations to examine the association between HDP and the neurodevelopmental outcomes of infants. Results The study found that infants exposed to HDP exhibited lower development quotients in total and individual neurodevelopmental domains at 3, 6, 8 and 12 months compared to infants without HDP exposure (all P < 0.05). Even after confounding factors were controlled, HDP exposure remained a significant risk factor for the neurodevelopment of infants, with the partial regression coefficient (β) and (95% CI) of -5.72 (-6.80--4.63). Specifically, HDP exposure was negatively associated with gross motor, fine motor, adaptability, language, and social behavior development, with a partial regression coefficients (β) and 95% CI of -5.35 (-6.86--3.84), -5.64 (-6.92--4.35), -5.88 (-7.26--4.49), -5.80 (-7.10--4.50) and -5.91(-7.11--4.72), respectively. Conclusions HDP has been identified as a risk factor for the neurodevelopment of infants, exhibiting negative associations with the development of gross motor, fine motor, adaptability, language and social behavior
- Hypertension,
- Pregnancy-induced,
- Child development,
- Neurodevelopmental disorders

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References(20)

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